Immature Retinal Vasculature in Zone 3

2020 ◽  
Author(s):  
Keyword(s):  
Retinal Vasculature

The effect of insulin pump therapy in retinal vasculature in type 1 diabetic patients

2021 ◽  
pp. 112067212199057
Author(s):  
Tomás de Oliveira Loureiro ◽  
João Nobre Cardoso ◽  
Carlos Diogo Pinheiro Lima Lopes ◽  
Ana Rita Carreira ◽  
Sandra Rodrigues-Barros ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Metabolic Control ◽  
Insulin Pump Therapy ◽  
Vascular Density ◽  
Diabetic Patients ◽  
Retinal Vasculature ◽  
Increased Risk ◽  
The Mean ◽  
Type 1 Diabetic Patients

Background/objectives: Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vasculature. Methods: We performed a prospective study with type 1 diabetic patients with no prior history of ocular pathology other than mild diabetic retinopathy. The patients were divided into two groups according to their therapeutic modality (CSII vs MDI). The retinal nerve fiber layers thickness and vascular densities were compared between groups in both macula and optic disc. The correlations between vascular density and clinical features were also determined. Statistical significance was defined as p < 0.05. Results: The study included 52 eyes, 28 in the insulin CSII group. The mean age was 36.66 ± 12.97 years, with no difference between groups ( p = 0.49). The mean glycated hemoglobin (HbA1c) was found to be lower in the CSII group (7.1% ± 0.7 vs 7.5% ± 0.7 p < 0.01). The parafoveal vascular density was found to be higher in the CSII group (42.5% ± 0.4 vs 37.7% ± 0.6, p < 0.01). We found an inverse correlation between HbA1c value and parafoveal vascular densities ( p < 0.01, r = −0.50). Conclusion: We found that CSII provided better metabolic control than MDI and this seemed to result in higher parafoveal vascular density. As lower vascular density is associated with an increased risk of diabetic retinopathy, these results suggest that CSII could be the safest therapeutic option to prevent retinopathy.

Response to the effect of pharmacologic treatment of migraine on retinal vasculature

2021 ◽  
pp. 112067212110280
Author(s):  
Julio González-Martín-Moro ◽  
Jesús Porta Etessam ◽  
Belén Pilo de la Fuente ◽  
Irene Fuentes Vega ◽  
Inés Contreras
Keyword(s):  
Retinal Vasculature ◽  
Pharmacologic Treatment

Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane

1994 ◽  
Vol 72 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Daniel Abran ◽  
Daya R. Varma ◽  
Ding-You Li ◽  
Sylvain Chemtob
Keyword(s):  
Blood Flow ◽  
Receptor Agonist ◽  
Perfusion Pressure ◽  
Retinal Blood Flow ◽  
Receptor Subtype ◽  
Retinal Vasculature ◽  
Receptor Subtypes ◽  
Retinal Vessels ◽  
Limit Blood Flow ◽  
Arteries And Veins

The upper blood pressure limit of retinal blood flow autoregulation is lower in the newborn than in the adult; this suggests an insufficient vasoconstrictor response in the newborn when perfusion pressure is increased. Because prostaglandins (PGs) have an important role in autoregulation of retinal blood flow, we compared the effects of PGE2, PGF2α, carbacyclin (PGI2 analogue), and U46619 (thromboxane analogue), as well as that of agonists for the three different PGE2 receptor subtypes, 17-phenyl trinor PGE2 (EP1), butaprost (EP2), and M&B 28,767 (EP3), on the retinal vasculature of newborn and adult pigs, using isolated eyecup preparations. PGF2α and PGE2 caused a markedly greater constriction of retinal arteries and veins of the adult than of the newborn animals. Further analysis of the response to PGE2, using receptor subtype agonists, revealed that the EP1 receptor agonist, 17-phenyl trinor PGE2, and the EP3 receptor agonist, M&B 28,767, caused a significant constriction of adult arteries and veins but produced minimal effects on newborn vessels; the EP2 receptor agonist, butaprost, caused a small and comparable dilation of newborn and adult arteries and veins. The PGI2 analogue, carbacyclin, caused a greater dilation of the adult than of the newborn arteries, but produced comparable dilation of veins from both newborn and adult animals. In contrast to the effects of PGF2α and PGE2, the thromboxane analogue, U46619, as well as the α1-adrenoceptor agonist, phenylephrine, significantly constricted newborn arteries and veins, and this effect was comparable with that observed on retinal vessels of the adult. Our findings indicate that the retinal vasculature of the newborn responds minimally to prostaglandins, primarily PGF2α and PGE2, compared with the adult, but constricts effectively to thromboxane. Since prostaglandins play an important role in the autoregulation of retinal blood flow, our observations provide an explanation for the inability of the newborn to limit blood flow when perfusion pressure is raised.Key words: retinal vascular responses, prostaglandins, thromboxane, PGE2 receptor subtypes.

On the retinal vasculature of the human fovea

1974 ◽  
Vol 19 (5) ◽  
pp. 409-417 ◽  
Author(s):  
Alan C. Bird ◽  
Robert A. Weale
Keyword(s):  
Retinal Vasculature

The Retinal Vasculature and Function of the Neural Retina in a Rat Model of Retinopathy of Prematurity

2006 ◽  
Vol 47 (6) ◽  
pp. 2639 ◽  
Author(s):  
Kegao Liu ◽  
James D. Akula ◽  
Christopher Falk ◽  
Ronald M. Hansen ◽  
Anne B. Fulton
Keyword(s):  
Rat Model ◽  
Retinopathy Of Prematurity ◽  
Neural Retina ◽  
Retinal Vasculature ◽  
And Function

scholarly journals Retinal Vasculature Reactivity During Flicker Light Provocation, Cardiac Stress and Stroke Risk in Africans: The SABPA Study

2018 ◽  
Vol 10 (5) ◽  
pp. 485-494 ◽  
Author(s):  
Annemarie Wentzel ◽  
Leoné Malan ◽  
Wayne Smith ◽  
Roland von Känel ◽  
Nicolaas T. Malan
Keyword(s):  
Stroke Risk ◽  
Retinal Vasculature ◽  
Cardiac Stress ◽  
Flicker Light

Chapter 10 Plasticity of the retinal vasculature

1986 ◽  
Vol 5 ◽  
pp. 253-307 ◽  
Author(s):  
Margaret S. Burns ◽  
Roy W. Bellhorn ◽  
Gary E. Korte ◽  
Wilson J. Heriot
Keyword(s):  
Retinal Vasculature

Retinal vasculature of the pig

1965 ◽  
Vol 4 (3) ◽  
pp. 174-IN14 ◽  
Author(s):  
J.M.B. Bloodworth ◽  
H.P. Gutgesell ◽  
R.L. Engerman
Keyword(s):  
Retinal Vasculature
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