scholarly journals Pentamidine Isethionate

2020 ◽  
Author(s):  
Keyword(s):  
Pentamidine Isethionate

scholarly journals Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

2017 ◽  
Vol 47 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Claudia Dantas COMANDOLLI-WYREPKOWSKI ◽  
Iryna GRAFOVA ◽  
Maricleide de Farias NAIFF ◽  
Maurizio AVELLA ◽  
Gennaro GENTILE ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Usnic Acid ◽  
Parasite Burden ◽  
Experimental Treatment ◽  
Mesocricetus Auratus ◽  
Current Treatment ◽  
Tissue Samples ◽  
Golden Hamsters ◽  
Pentamidine Isethionate

ABSTRACT Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission electron microscopy and biopsy cultivation. Compared with untreated group, topical treatment with hydrating emulsion with 10% PI and usnic acid (ACE5AU) showed significantly decrease in volume lesion (P= 0.028) on 20th day after the end of the treatment with reduction of 27.37%. Topical treatment with anhydrous emulsion with 10% PI and usnic acid (ACPU) reduces parasite burden in Golden hamsters. This study demonstrated the potential of topical treatment to reduce the number of parasites that could be combined with others drugs and to have a faster and more effective treatment of cutaneous leishmaniasis.

scholarly journals Exposure of health care workers to pentamidine isethionate

1999 ◽  
Vol 49 (4) ◽  
pp. 243-245 ◽  
Author(s):  
J. R. Beach ◽  
M. Campbell ◽  
D. J. Andrews
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Care Workers ◽  
Pentamidine Isethionate

scholarly journals Aerosolised pentamidine for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome

1990 ◽  
Vol 32 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Adriana Weinberg ◽  
Sebastião A. Dantonio ◽  
Maria Irma S. Duarte ◽  
Wilson L. Pedreira Jr. ◽  
Antonio A. Barone ◽  
...  
Keyword(s):  
Pneumocystis Carinii ◽  
Pneumocystis Pneumonia ◽  
Early Recurrence ◽  
First Episode ◽  
Drug Discontinuation ◽  
Major Toxicity ◽  
Pentamidine Isethionate ◽  
Acquired Immunodeficiency ◽  
Group 2 ◽  
Immunodeficiency Syndrome

The goal of this study was to evaluate inhaled pentamidine for the treatment of patients with mild and moderate Pneumocystis carinii pneumonitis. Eight adults with AIDS and pneumocystis pneumonia (4 with a first episode and 4 with a repeat pneumocystosis) received daily inhalations of aerosol pentamidine isethionate for 21 days. Six patients were treated with doses of 300 mg of pentamidine and the remaining 2 received 600 mg every day. In the 300 mg treatment group, 2 individuals showed discrete and transient neutropenia. However, both subjects that received 600 mg of aerosol pentamidine daily developed leukopenia. One of them had major toxicity (overall severe intolerance of 12.5%) that required drug discontinuation and did not allow any analysis of the treatment efficacy. Of the 7 evaluable patients, 6 (88%) completed the treatment successfuly. One subject of the 300 mg regimen experienced an early recurrence. In conclusion, inhaled pentamidine is an effective treatment for mild and moderate cases of P. carinii pneumonia. It is less toxic than standard anti-pneumocystis therapy and is suitable for outpatient use.

An evaluation of the mechanism of action of pentamidine isethionate

1970 ◽  
Vol 2 (4) ◽  
pp. 393-398 ◽  
Author(s):  
Richard S. Bornstein ◽  
J. W. Yarbro
Keyword(s):  
Mechanism Of Action ◽  
Pentamidine Isethionate

Pentamidine Isethionate as Treatment and Secondary Prophylaxis for Disseminated Cutaneous Leishmaniasis During HIV Infection: Case Report

2001 ◽  
Vol 13 (6) ◽  
pp. 653-657 ◽  
Author(s):  
L. Calza ◽  
G. Marinacci ◽  
R. Manfredi ◽  
V. Colangeli ◽  
L. Fortunato ◽  
...  
Keyword(s):  
Case Report ◽  
Hiv Infection ◽  
Cutaneous Leishmaniasis ◽  
Secondary Prophylaxis ◽  
Pentamidine Isethionate
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