scholarly journals Kinase Suppressor of Ras 2

2020 ◽  
Author(s):  
Keyword(s):  
Kinase Suppressor Of Ras

scholarly journals Disease-associated scaffold protein CNK2 modulates PSD size and influences trafficking of new synaptic binding partner TNIK

2019 ◽  
Author(s):  
Hanna L. Zieger ◽  
Stella-Amrei Kunde ◽  
Nils Rademacher ◽  
Bettina Schmerl ◽  
Sarah A. Shoichet
Keyword(s):  
Scaffold Protein ◽  
Subcellular Localisation ◽  
The Novel ◽  
Developmental Defects ◽  
Binding Partner ◽  
Neuronal Dendrites ◽  
Interaction Partners ◽  
Kinase Suppressor Of Ras ◽  
Synaptic Markers

AbstractScaffold proteins are responsible for structural organisation within cells; they form complexes with other proteins to facilitate signalling pathways and catalytic reactions. The scaffold protein connector enhancer of kinase suppressor of Ras 2 (CNK2) is predominantly expressed in neural tissues and was recently implicated in X-linked intellectual disability (ID). We have investigated the role of CNK2 in neurons in order to contribute to our understanding of how CNK2 alterations might cause developmental defects, and we have elucidated a functional role for CNK2 in the molecular processes that govern morphology of the postsynaptic density (PSD). We have also identified novel CNK2 interaction partners and explored their functional interdependency with CNK2. We focussed on the novel interaction partner TRAF2- and NCK-interacting kinase TNIK, which is also associated with ID. Both CNK2 and TNIK are expressed in neuronal dendrites and concentrated in dendritic spines, and staining with synaptic markers indicates a clear postsynaptic localisation. Importantly, our data highlight that CNK2 plays a role in directing TNIK subcellular localisation, and in neurons, CNK2 participates in ensuring that this multifunctional kinase is present at desirable levels at synaptic sites. In summary, our data indicate that CNK2 expression is critical for modulating PSD morphology; moreover, our study highlights a role for CNK2 in directing the localisation of regulatory proteins within the cell. Importantly, we describe a novel link between CNK2 and the regulatory kinase TNIK, and provide evidence supporting the idea that these proteins play complementary roles in the regulation of dendritic spine growth and maintenance.

scholarly journals Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation

2004 ◽  
Vol 114 (9) ◽  
pp. 1272-1280 ◽  
Author(s):  
Fang Yan ◽  
Sutha K. John ◽  
Guinn Wilson ◽  
David S. Jones ◽  
M. Kay Washington ◽  
...  
Keyword(s):  
Intestinal Epithelium ◽  
Kinase Suppressor Of Ras

scholarly journals Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1621 ◽  
Author(s):  
Danielle Frodyma ◽  
Beth Neilsen ◽  
Diane Costanzo-Garvey ◽  
Kurt Fisher ◽  
Robert Lewis
Keyword(s):  
Energy Balance ◽  
Small Molecule ◽  
Physiological Role ◽  
Molecular Scaffolds ◽  
Potent Effect ◽  
Molecular Scaffold ◽  
Kinase Suppressor Of Ras ◽  
Kinase Cascade ◽  
Reduced Toxicity ◽  
Erk Kinase

Many cancers, including those of the colon, lung, and pancreas, depend upon the signaling pathways induced by mutated and constitutively active Ras. The molecular scaffolds Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) play potent roles in promoting Ras-mediated signaling through the Raf/MEK/ERK kinase cascade. Here we summarize the canonical role of KSR in cells, including its central role as a scaffold protein for the Raf/MEK/ERK kinase cascade, its regulation of various cellular pathways mediated through different binding partners, and the phenotypic consequences of KSR1 or KSR2 genetic inactivation. Mammalian KSR proteins have a demonstrated role in cellular and organismal energy balance with implications for cancer and obesity. Targeting KSR1 in cancer using small molecule inhibitors has potential for therapy with reduced toxicity to the patient. RNAi and small molecule screens using KSR1 as a reference standard have the potential to expose and target vulnerabilities in cancer. Interestingly, although KSR1 and KSR2 are similar in structure, KSR2 has a distinct physiological role in regulating energy balance. Although KSR proteins have been studied for two decades, additional analysis is required to elucidate both the regulation of these molecular scaffolds and their potent effect on the spatial and temporal control of ERK activation in health and disease.

scholarly journals Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0211134 ◽  
Author(s):  
Stephanie Rock ◽  
Xian Li ◽  
Jun Song ◽  
Courtney M. Townsend ◽  
Heidi L. Weiss ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Kinase Suppressor Of Ras

scholarly journals Nm23-H1 Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway

2002 ◽  
Vol 277 (35) ◽  
pp. 32389-32399 ◽  
Author(s):  
Melanie T. Hartsough ◽  
Deborah K. Morrison ◽  
Massimiliano Salerno ◽  
Diane Palmieri ◽  
Taoufik Ouatas ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Metastasis Suppressor ◽  
Histidine Protein Kinase ◽  
Kinase Suppressor Of Ras ◽  
Kinase Pathway

Abstract A16: Overexpression and ubiquitination of kinase suppressor of Ras 1 (KSR1) in human colon tumor cells

2014 ◽  
Author(s):  
Jamie L. McCall ◽  
Ken Kono ◽  
Kurt W. Fisher ◽  
Manabu Furukawa ◽  
Robert E. Lewis
Keyword(s):  
Tumor Cells ◽  
Human Colon ◽  
Colon Tumor ◽  
Kinase Suppressor Of Ras

scholarly journals Kinase suppressor of Ras transphosphorylates c-Raf-1

2009 ◽  
Vol 390 (3) ◽  
pp. 434-440 ◽  
Author(s):  
Mohammad Zafrullah ◽  
Xianglei Yin ◽  
Adriana Haimovitz-Friedman ◽  
Zvi Fuks ◽  
Richard Kolesnick
Keyword(s):  
Kinase Suppressor Of Ras
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