scholarly journals High nicotine concentration e-liquid

2021 ◽  
Author(s):  
Keyword(s):  
Nicotine Concentration

scholarly journals Triangulating abuse liability assessment for flavoured cigar products using physiological, behavioural economic and subjective assessments: a within-subjects clinical laboratory protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e023850
Author(s):  
Catherine S Wall ◽  
Rose S Bono ◽  
Rebecca C Lester ◽  
Cosima Hoetger ◽  
Thokozeni Lipato ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Subjective Effects ◽  
Latin Square ◽  
Abuse Liability ◽  
Smoke Inhalation ◽  
Nicotine Concentration ◽  
The Past ◽  
The Usa ◽  
Behavioural Economic ◽  
Scientific Meetings

IntroductionIn the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted. Such flavourings influence positive perceptions of tobacco products and are linked to increased use. Flavourings may mask the taste of tobacco and enhance smoke inhalation, influencing toxicant exposure and abuse liability among novice tobacco users. Using clinical laboratory methods, this study investigates how flavour availability affects measures of abuse liability in young adult cigarette smokers. The specific aims are to evaluate the effect of cigar flavours on nicotine exposure, and behavioural and subjective measures of abuse liability.Methods and analysesParticipants (projected n=25) are healthy smokers of five or more cigarettes per day over the past 3 months, 18–25 years old, naive to cigar use (lifetime use of 50 or fewer cigar products and no more than 10 cigars smoked in the past 30 days) and without a desire to quit cigarette smoking in the next 30 days. Participants complete five laboratory sessions in a Latin square design with either their own brand cigarette or a session-specific Black & Mild cigar differing in flavour (apple, cream, original and wine). Participants are single-blinded to cigar flavours. Each session consists of two 10-puff smoking bouts (30 s interpuff interval) separated by 1 hour. Primary outcomes include saliva nicotine concentration, behavioural economic task performance and response to various questionnaire items assessing subjective effects predictive of abuse liability. Differences in outcomes across own brand cigarette and flavoured cigar conditions will be tested using linear mixed models.Ethics and disseminationThe Virginia Commonwealth University Institutional Review Board approved the study (VCU IRB: HM20007848). Dissemination channels for study findings include scientific journals, scientific meetings, and policy briefs.Trial registration numberNCT02937051.

scholarly journals Electronic cigarette use intensity measurement challenges and regulatory implications

2021 ◽  
pp. tobaccocontrol-2021-056483
Author(s):  
Eric Soule ◽  
Maansi Bansal-Travers ◽  
Rachel Grana ◽  
Scott McIntosh ◽  
Simani Price ◽  
...  
Keyword(s):  
Tobacco Use ◽  
User Behavior ◽  
Unintended Consequences ◽  
Electronic Cigarette ◽  
Cigarette Use ◽  
Tobacco Products ◽  
Intensity Measures ◽  
Nicotine Concentration ◽  
Regulatory Policies ◽  
Answering Questions

Assessing tobacco use intensity allows researchers to examine tobacco use in greater detail than assessing ever or current use only. Tobacco use intensity measures have been developed that are specific to tobacco products, such as asking smokers to report number of cigarettes smoked per day. However, consensus on electronic cigarette use intensity measures that can be used for survey research has yet to be established due to electronic cigarette product and user behavior heterogeneity. While some survey measures that attempt to assess electronic cigarette use intensity exist, such as examining number of ‘times’ using an electronic cigarette per day, number of puffs taken from an electronic cigarette per day, volume of electronic cigarette liquid consumed per day, or nicotine concentration of electronic cigarette liquid, most measures have limitations. Challenges in electronic cigarette measurement often stem from variations across electronic cigarette device and liquid characteristics as well as the difficulty that many electronic cigarette users have regarding answering questions about their electronic cigarette device, liquid, or behavior. The inability for researchers to measure electronic cigarette use intensity accurately has important implications such as failing to detect unintended consequences of regulatory policies. Development of electronic cigarette use intensity measures, though not without its challenges, can improve understanding of electronic cigarette use behaviors and associated health outcomes and inform development of regulatory policies.

scholarly journals Alternative pathways of zeaxanthin biosynthesis in a Flavobacterium species. Experiments with nicotine as inhibitor

1974 ◽  
Vol 144 (2) ◽  
pp. 231-243 ◽  
Author(s):  
J C B McDermott ◽  
D J Brown ◽  
G Britton ◽  
T W Goodwin
Keyword(s):  
Cyclization Reaction ◽  
Biosynthetic Pathways ◽  
Anaerobic Conditions ◽  
Anaerobic Process ◽  
Alternative Pathways ◽  
Nicotine Concentration ◽  
Β Carotene

In Flavobacterium R1519, nicotine blocks zeaxanthin biosynthesis by specifically inhibiting the cyclization reaction. Lycopene (at high nicotine concentrations, e.g. 7.5mm) and rubixanthin (at low nicotine concentration, e.g. 1mm) replace zeaxanthin as the main carotenoid. On removal of the nicotine lycopene is converted into β-carotene under anaerobic conditions and into zeaxanthin in the presence of O2. The conversion in vivo of β-carotene into zeaxanthin was also demonstrated. Cyclization (an anaerobic process) thus precedes hydroxylation (O2-requiring) in the biosynthesis of zeaxanthin. The conversion in vivo of rubixanthin into β-cryptoxanthin and into zeaxanthin was demonstrated, thus indicating the operation of alternative pathways of zeaxanthin biosynthesis. Several alternative biosynthetic pathways are considered and the results are also discussed in terms of reaction sequences of carotenoid ‘half-molecules’.

Electrical features, liquid composition and toxicant emissions from ‘pod-mod’-like disposable electronic cigarettes

2021 ◽  
pp. tobaccocontrol-2020-056362
Author(s):  
Soha Talih ◽  
Rola Salman ◽  
Eric Soule ◽  
Rachel El-Hage ◽  
Ebrahim Karam ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Young Adults ◽  
Electronic Cigarettes ◽  
Electrical Power ◽  
Liquid Composition ◽  
Gas Chromatography Mass Spectrometry ◽  
Aerosol Composition ◽  
Public Health Perspective ◽  
Nicotine Concentration ◽  
Youth And Young Adults

IntroductionUse of flavoured pod-mod-like disposable electronic cigarettes (e-cigarettes) has grown rapidly, particularly among cost-sensitive youth and young adults. To date, little is known about their design characteristics and toxicant emissions. In this study, we analysed the electrical and chemical characteristics and nicotine and pulmonary toxicant emission profiles of five commonly available flavoured disposable e-cigarettes and compared these data with those of a JUUL, a cartridge-based e-cigarette device that pod-mod-like disposables emulate in size and shape.MethodsDevice construction, electrical power and liquid composition were determined. Machine-generated aerosol emissions including particulate matter, nicotine, carbonyl compounds and heavy metals were also measured. Liquid and aerosol composition were measured by high-performance liquid chromatography, gas chromatography-mass spectrometry/flame ionisation detection, and inductively coupled plasma mass spectrometry.ResultsWe found that unlike JUUL, disposable devices did not incorporate a microcontroller to regulate electrical power to the heating coil. Quality of construction varied widely. Disposable e-cigarette power ranged between 5 and 9 W and liquid nicotine concentration ranged between 53 and 85 mg/mL (~95% in the protonated form). In 15 puffs, total nicotine yield for the disposables ranged between 1.6 and 6.7 mg, total carbonyls ranged between 28 and 138 µg, and total metals ranged between 1084 and 5804 ng. JUUL emissions were near the floors of all of these ranges.ConclusionsDisposable e-cigarettes are designed with high nicotine concentration liquids and are capable of emitting much higher nicotine and carbonyl species relative to rechargeable look-alike e-cigarettes. These differences are likely due to the lower quality in construction, unreliable labelling and lack of temperature control regulation that limits the power during operation. From a public health perspective, regulating these devices is important to limit user exposure to carbonyls and nicotine, particularly because these devices are popular with youth and young adults.

E-cigarettes and vaping – a panacea or a bane to smoking in current times?

2020 ◽  
pp. 103985622095009
Author(s):  
Guna Kanniah ◽  
Shailesh Kumar ◽  
Soumil Prasad
Keyword(s):  
Mental Illness ◽  
Smoking Cessation ◽  
Serious Mental Illness ◽  
Safety Profile ◽  
Tobacco Industry ◽  
Electronic Cigarettes ◽  
Cigarette Use ◽  
Nicotine Concentration ◽  
The World

Objective: Use of electronic cigarettes has increased across the world in the last decade with heavy investment from the tobacco industry targeting younger population through well-designed marketing campaigns portraying e-cigarettes as harmless, less addictive and effective in smoking cessation while delivering higher nicotine concentration. The safety profile of e-cigarettes is reviewed in this paper. Conclusions: The safety of e-cigarettes and the chemicals they contain have not been evaluated rigorously. Emerging data suggest e-cigarette use could do severe harm. People with serious mental illness, already the highest nicotine consumers, could be exploited by the tobacco industry.

scholarly journals The Effects of Transdermal Nicotine Patches on the Cardiorespiratory and Lactate Responses During Exercise from Light to Moderate Intensity: Implications for Exercise Prescription during Smoking Cessation

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 348
Author(s):  
Takashi Nakagata ◽  
Kosuke Fukao ◽  
Hiroyuki Kobayashi ◽  
Shizuo Katamoto ◽  
Hisashi Naito
Keyword(s):  
Perceived Exertion ◽  
Peak Level ◽  
Random Order ◽  
Cycle Ergometer ◽  
Moderate Intensity ◽  
Nicotine Concentration ◽  
Nicotine Patches ◽  
Transdermal Nicotine ◽  
Study Results ◽  
Young Smokers

Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs) in smokers. This study aimed to investigate the effect of TNPs on the cardiorespiratory and La responses during exercise at light to moderate intensity. Materials and Methods: Fourteen young men (8 non-smokers, 6 current smokers) aged 20 to 26 years participated in this study. They performed an incremental graded submaximal exercise test using an electromagnetic cycle ergometer set from 30 to 210 W with (TNP condition) or without a TNP (control condition) in a random order. The TNP was applied to the left arm 8–10 h prior to starting the exercise to achieve the peak level of blood nicotine concentration. Heart rate (HR), rate of perceived exertion (RPE), oxygen consumption (VO2), ventilation (VE), and blood La at rest and during exercise were measured and analyzed. Results: The HR at rest was significantly higher in the TNP condition than in the control condition (TNP; 74.7 ± 13.8 bpm, control; 65.3 ± 10.8 bpm, p < 0.001). There was no interaction (condition × exercise intensity) between any of the variables, and VO2, VE, RPE, and La during exercise were not significantly different between the conditions. However, HR during exercise was 6.7 bpm higher on average in the TNP condition. Conclusions: The HR during exercise was greater at light to moderate intensity with a TNP. Our study results will guide clinicians or health professionals when prescribing exercise programs combined with TNPs for healthy young smokers.

Nicotine arms race: JUUL and the high-nicotine product market

2019 ◽  
Vol 28 (6) ◽  
pp. 623-628 ◽  
Author(s):  
Robert K Jackler ◽  
Divya Ramamurthi
Keyword(s):  
Market Share ◽  
Product Market ◽  
Arms Race ◽  
Online Search ◽  
Protective Measures ◽  
Nicotine Concentration ◽  
Consumer Confusion ◽  
Childhood Poisoning ◽  
Cigarette Packs

ObjectiveUntil recently, purveyors of vaping products marketed e-liquids in the 1%–3% range of nicotine concentration with those at 3% described as ‘super high’ intended for two packs/day smokers. The goal of this study is to evaluate the degree to which JUUL, with its 5% nicotine and 75% US market share, has spurred other e-liquid vendors to raise the nicotine levels of their products.MethodsOnline search to identify brands offering e-liquid in exceptionally high nicotine concentration (≥5%) and to catalogue the appearance of devices which emulate JUUL.ResultsJUUL compatible pods (14) and JUUL knock off devices (39) were identified which offer equal or higher nicotine than JUUL. More than 70 e-liquid brands sell high-nicotine products (≥5%) in bulk (≥30 mL) equivalent to >40 cigarette packs. All of these products come in multiple youth appealing sweet and fruity flavours. It was noted that nicotine percentage is inconsistently reported (eg, JUUL is 5% by weight vs 5.9% by volume).ConclusionsJUUL has triggered a widespread rush among aerosol purveyors to market e-liquid in unprecedentedly high nicotine concentrations. The rapidly rising popularity of high-nicotine e-liquids threatens to addict a generation of youth. When sold in large quantity bottles (eg, 30 mL) they represent a childhood poisoning risk. Labelling of nicotine concentration in e-liquids needs to be standardised to avoid consumer confusion. The addictiveness and toxicity of these products makes it imperative that regulators act swiftly to enact protective measures.

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