scholarly journals Cytochrome P450 3A5

2020 ◽  
Author(s):  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 3A5

The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity

2018 ◽  
Vol 47 (3) ◽  
pp. 182-190 ◽  
Author(s):  
Suwasin Udomkarnjananun ◽  
Natavudh Townamchai ◽  
Pajaree Chariyavilaskul ◽  
Kroonpong Iampenkhae ◽  
Krit Pongpirul ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Calcineurin Inhibitor ◽  
Cox Regression ◽  
Kidney Tissue ◽  
Acute Rejection Episode ◽  
Genotype 3 ◽  
Kidney Allograft ◽  
Cytochrome P450 3A5 ◽  
Calcineurin Inhibitor Nephrotoxicity ◽  
Donor Genotype

Background: Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and transplant outcomes. Methods: We conducted a retrospective cohort study at the King Chulalongkorn Memorial Hospital, Thailand, comparing 2 groups of donor and recipient CYP3A5 genotypes, the expressor (*1/*1 and *1/*3) and the non-expressor (*3/*3). The primary outcomes were allograft complications including calcineurin inhibitor (CNI) nephrotoxicity and acute rejection episode. Results: Of the 50 enrolled patients, 21 donors were expressors and 29 donors were the non-expressors. Tacrolimus trough concentrations were similar between the 2 genotypes. The incidence of CNI nephrotoxicity was higher in recipients with non-expressor donor genotype compared with the expressor donor genotype (72.4 vs. 33.3%, p = 0.006). CNI nephrotoxicity incidence was not different when recipient’s genotypes were compared. Multivariate analysis from Cox-regression showed a hazard ratio of 3.18 (p = 0.026) for CNI nephrotoxicity in the non-expressor compared with the expressor donor. The recipient CYP3A5 genotypes did not significantly contribute to CNI nephrotoxicity. Kaplan-Meier analysis demonstrated the lowest CNI nephrotoxicity-free survival in recipients with the expressor genotype who received allograft from the non-expressor donors (p = 0.005). Conclusion: In conclusion, our results suggest that donor CYP3A5 non-expressor genotype (*3/*3) is a risk for CNI nephrotoxicity.

Association between cytochrome P450 3A5 polymorphism and the lung function in Saskatchewan grain workers

2008 ◽  
Vol 18 (6) ◽  
pp. 487-493 ◽  
Author(s):  
Takayuki Seo ◽  
Punam Pahwa ◽  
Helen H. McDuffie ◽  
Keigo Yurube ◽  
Masayoshi Egoshi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Lung Function ◽  
Cytochrome P450 3A5 ◽  
Grain Workers

Pharmacogenetic biomarkers: cytochrome P450 3A5

2012 ◽  
Vol 413 (17-18) ◽  
pp. 1312-1317 ◽  
Author(s):  
Iain A.M. MacPhee
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 3A5

Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients12

2003 ◽  
Vol 76 (8) ◽  
pp. 1233-1235 ◽  
Author(s):  
Eric Thervet ◽  
Dany Anglicheau ◽  
Barry King ◽  
Marie-H??l??ne Schlageter ◽  
Bruno Cassinat ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Renal Transplant ◽  
Dose Ratio ◽  
Cytochrome P450 3A5
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