Fluvoxamine Maleate

OPTIMIZATION OF THIN LAYER CHROMATOGRAPHY METHODS FOR SEPARATION AND IDENTIFICATION OF ANTIDEPRESSANTS IN THEIR MIXTURE

Medicinos teorija ir praktika ◽

10.15591/mtp.2015.002 ◽

2014 ◽

Vol 21 (1) ◽

pp. 11-15

Author(s):

Daiva Kazlauskienė ◽

Guoda Kiliuvienė ◽

Palma Nenortienė ◽

Giedrė Kasparavičienė ◽

Ieva Matukaitytė

Keyword(s):

Thin Layer ◽

Thin Layer Chromatography ◽

Solvent System ◽

Ammonia Solution ◽

Relative Standard ◽

Rf Values ◽

Solvent Systems ◽

Paroxetine Hydrochloride ◽

Fluvoxamine Maleate ◽

Layer Chromatography

By conducting the toxicological analysis it is meaningful to determine the analytical system that could identify simultaneously several medicinal preparations quickly and precisely. The purpose of this work was to create and validate the method of thin-layer chromatography that would be suitable to separate the components of antidepressant mixture (amitriptyline hydrochloride, paroxetine hydrochloride, sertraline hydrochloride, fluvoxamine maleate and buspirone hydrochloride) and to identify them. The system was validated with regard to the sensitivity, repetition of data, resistance and particularity. The solvent systems with potential of high separation of components in their mixture were created: acetonitrile, methanol, ammonia solution 25 percent (85:10:5); acetonitrile, methanol, ammonia solution 25 percent (75:20:5); dichlormethane, 1,4-dioxane, ammonia solution 25 percent (50:45:5); dichlormethane, 1,4-dioxane, ammonia solution 25 percent (42:55:3); trichlormethane, 1,4-dioxane, ammonia solution 25 percent (25:70:5); trichlormethane, 1,4-dioxane, ammonia solution 25 percent (60:36:4). One of the most suitable solvent systems for separation of the analyzed mixture (sertraline, amitriptyline, paroxetine, buspirone, fluvoxamine) was determined – acetonitrile, methanol, ammonia solution 25 percent (85:10:5). When this solvent system was used, the average Rf values of the analyzed compounds differed the most. Validation was conducted – the relative standard deviation (RSD, percent) of the average Rf value of the analyzed compounds varied from 0,6 to 1,8 percent and did not exceed the permissible error of 5 percent. The sensitivity of methodology was determined by assessing the intensity of the mixture’s spots on the chromatographic plate. The detection limit of buspirone was 0,0012 µg; sertraline – 0,0008 µg; amitriptyline – 0,0004 µg; fluvoxamine – 0,0004 µg; paroxetine – 0,0008 µg. The resistance of results to the changed conditions – it was determined that when the amounts of the solvents acetonitrile and methanol were increased or decreased to two milliliters, the average Rf values of the analyzed compounds did not change statistically significantly

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Non-extractive spectrophotometric determination of memantine HCl, clomipramine HCl and fluvoxamine maleate in pure form and in pharmaceutical products by ion-pair complex formation with rose bengal

Annales Pharmaceutiques Françaises ◽

10.1016/j.pharma.2020.11.009 ◽

2020 ◽

Author(s):

Rania A. Sayed ◽

Walaa El-Alfy ◽

Omnia A. Ismaiel ◽

Magda Y. El-Mammli ◽

Abdalla Shalaby

Keyword(s):

Complex Formation ◽

Spectrophotometric Determination ◽

Rose Bengal ◽

Pharmaceutical Products ◽

Ion Pair ◽

Pure Form ◽

Fluvoxamine Maleate

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The Polarographic Determination of Fluvoxamine Maleate

Analytical Letters ◽

10.1080/00032719408000284 ◽

1994 ◽

Vol 27 (6) ◽

pp. 1135-1145 ◽

Cited By ~ 5

Author(s):

M. Tunçel ◽

G. Altiokka ◽

Z. AtkoşsLar

Keyword(s):

Polarographic Determination ◽

Fluvoxamine Maleate

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Encyclopedia of Autism Spectrum Disorders ◽

10.1007/978-3-319-91280-6_300710 ◽

2021 ◽

pp. 2063-2063

Keyword(s):

Fluvoxamine Maleate

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Surfactant to dye binding degree method for the determination of fluvoxamine maleate and citalopram hydrobromide in pharmaceuticals

Open Chemistry ◽

10.2478/s11532-010-0011-5 ◽

2010 ◽

Vol 8 (3) ◽

pp. 536-542 ◽

Cited By ~ 3

Author(s):

Mohammad Amjadi ◽

Jamshid Manzoori ◽

Javad Hassanzadeh

Keyword(s):

Signal To Noise Ratio ◽

Sodium Dodecyl ◽

Neutral Red ◽

Optimum Conditions ◽

Surfactant Aggregates ◽

Dye Binding ◽

Absorbance Changes ◽

Fluvoxamine Maleate ◽

532 Nm

AbstractThe surfactant to dye binding degree (SBDB) methodology was used to determine fluvoxamine maleate and citalopram hydrobromide. Neutral red and sodium dodecyl sulfate (SDS) were used as the dye and surfactant, respectively, to form dye-surfactant aggregates. When a cationic drug is added to dye-surfactant mixture, it interacts with the surfactant and decreases the dye-surfactant binding degree. This decrease is proportional to the drug concentration. This was measured by monitoring the absorbance changes of the dye at 532 nm. Under the optimum conditions, the calibration graphs were linear over the range of 1.2–15 μg mL−1 and 1.1–15 μg mL−1 for fluvoxamine maleate and citalopram hydrobromide, respectively. The detection limits (signal to noise ratio = 3) were found to be 0.37 and 0.35 μg mL−1, for fluvoxamine maleate and citalopram hydrobromide, respectively.

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