scholarly journals Ovarian Stromal Hyperplasia

2020 ◽  
Author(s):  
2020 ◽  
Vol 26 (1) ◽  
pp. 39
Author(s):  
Teresa Lozoya Araque ◽  
Isauro Rogelio Monfort Ortiz ◽  
José Enrique Martín González ◽  
Alenda Jiménez García ◽  
Inmaculada Navarro Hidalgo ◽  
...  

1961 ◽  
Vol 21 (4) ◽  
pp. 472-477 ◽  
Author(s):  
PENG-HSIAO YIN ◽  
SHELDON C. SOMMERS

Oncogene ◽  
1998 ◽  
Vol 17 (21) ◽  
pp. 2711-2717 ◽  
Author(s):  
D Daphna-Iken ◽  
D B Shankar ◽  
A Lawshé ◽  
D M Ornitz ◽  
G M Shackleford ◽  
...  

2014 ◽  
Vol 24 (8) ◽  
pp. 1455-1460 ◽  
Author(s):  
Keisuke Ashihara ◽  
Tomohito Tanaka ◽  
Risa Maruoka ◽  
Yoshihiro J. Ono ◽  
Akiko Tanabe ◽  
...  

ObjectiveType 1 endometrial cancer (EC) is typically sex hormone sensitive; however, most women diagnosed with EC have already gone through menopause. Several studies have reported that the postmenopausal ovary is hormonally active, and estradiol (E2) production from the ovaries persists for as much as 10 years beyond menopause. The aim of this study was to evaluate whether sex steroid production from the ovaries contributes to the pathogenesis of type 1 EC.Materials and MethodsThis was a prospective study of 53 women treated for EC (28 cases of type 1 disease and 25 cases of type 2 disease). Serum specimens were collected from the peripheral and ovarian veins of participants undergoing bilateral oophorectomy. The sex steroid hormone levels and hormonal milieu on cervical cytology were evaluated as maturation value (MV). In addition, the degree of stromal hyperplasia of the ovary was evaluated histologically.ResultsAlthough the E2 levels of the peripheral veins did not show any significant differences [8.2 (5.1–12.4) vs 7.4 (5.1–11.7) pg/mL, respectively; P < 0.05], the patients with type 1 EC had a higher E2 level in the ovarian vein than those with type 2 EC [25 (13.8–42.5) vs 15 (10.0–23.0) pg/mL, respectively; P < 0.05]. There were also no significant differences in the rate of moderate to marked hyperplasia of the ovarian stroma between the groups; however, the thickness of the ovarian cortex demonstrated a correlation with the ovarian E2 level. In addition, the MV displayed a strong correlation with the ovarian E2 level, but not the peripheral E2 level.ConclusionsThe postmenopausal ovary is hormonally active, especially in patients with type 1 EC. The degree of ovarian stromal hyperplasia may (at least in part) contribute to the progression of type 1 EC, and MV may predict the level of E2 production from the ovaries in postmenopausal women.


1955 ◽  
Vol 10 (4) ◽  
pp. 581-582
Author(s):  
SHELDON C. SOMMERS ◽  
OLIVE M. LOMBARD

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