scholarly journals Chronic Villitis

2020 ◽  
Author(s):  
Keyword(s):  
Chronic Villitis

Placental Lesions Associated With Cerebral Palsy and Neurologic Impairment Following Term Birth

2000 ◽  
Vol 124 (12) ◽  
pp. 1785-1791 ◽  
Author(s):  
Raymond W. Redline ◽  
Mary Ann O'Riordan
Keyword(s):  
Cerebral Palsy ◽  
Labor And Delivery ◽  
Placental Pathology ◽  
Term Infants ◽  
Additional Lesion ◽  
Nucleated Red Blood Cells ◽  
Neurologic Impairment ◽  
Retrospective Comparison ◽  
Abruptio Placenta ◽  
Chronic Villitis

Abstract Objective.—The aim of this study was to determine the association of placental findings with cerebral palsy and related forms of neurologic impairment (NI) following birth at ≥37 weeks gestation (term). Design.—In a retrospective comparison, placentas from 40 term infants with NI ascertained on the basis of clinicopathologic review for medicolegal consultation were compared with placentas from 176 consecutive meconium-stained term infants at low risk for NI. Results.—After stratification for severity, 9 lesions were significantly increased in placentas from infants with NI: 5 lesions generally considered to occur within days of the time of labor and delivery (meconium-associated vascular necrosis, severe fetal chorioamnionitis, chorionic vessel thrombi, increased nucleated red blood cells, and findings consistent with abruptio placenta) and 4 lesions generally believed to have their onset long before labor and delivery (diffuse chronic villitis, extensive avascular villi, diffuse chorioamnionic hemosiderosis, and perivillous fibrin). Findings independently associated with NI by logistic regression in this descriptive study were severe fetal chorioamnionitis (odds ratio [OR], 13.2; 95% confidence interval [CI], 1.2–144); extensive avascular villi (OR, 9.0; 95% CI, 1.6–51); and diffuse chorioamnionic hemosiderosis (OR, 74.8; 95% CI, 6.3–894). The risk of NI increased as a function of the number of lesions present (OR, 10.1; 95% CI, 5.1–20 for each additional lesion), particularly when lesions generally considered to occur near the time of labor and those believed to occur well before labor were found in the same placenta (OR, 94.2; 95% CI, 11.9–747). Conclusions.—These findings suggest that placental pathology can contribute to an understanding of the mechanisms that contribute to NI at term.

The clinical significance of severe chronic villitis of the placenta

1995 ◽  
Vol 172 (1) ◽  
pp. 311
Author(s):  
S. Shen-Schwartz ◽  
S. Sengupia ◽  
Y. Lal ◽  
P. Gregory ◽  
J. Smulian
Keyword(s):  
Clinical Significance ◽  
Chronic Villitis

Perinatal prognosis of pregnancies complicated by placental chronic villitis or intervillositis of unknown etiology and combined lesions: About a series of 178 cases

Placenta ◽  
2016 ◽  
Vol 44 ◽  
pp. 104-108 ◽  
Author(s):  
Christel Nowak ◽  
Madeleine Joubert ◽  
Frederique Jossic ◽  
Agathe Masseau ◽  
Mohamed Hamidou ◽  
...  
Keyword(s):  
Unknown Etiology ◽  
Combined Lesions ◽  
Chronic Villitis

scholarly journals D2-40/podoplanin expression in chronic villitis of the placenta

2018 ◽  
Vol 54 (2) ◽  
Author(s):  
Erika S. Abu Egal ◽  
Juliana S. Nascimento ◽  
Fernanda Meireles ◽  
Amílcar C. Mattos ◽  
Harim T. Santos ◽  
...  
Keyword(s):  
Podoplanin Expression ◽  
Chronic Villitis

Seasonal Variation of Chronic Villitis of Unknown Etiology

2019 ◽  
Vol 23 (4) ◽  
pp. 253-259
Author(s):  
Alexa A Freedman ◽  
Jeffery A Goldstein ◽  
Gregory E Miller ◽  
Ann Borders ◽  
Lauren Keenan-Devlin ◽  
...  
Keyword(s):  
Seasonal Variation ◽  
Inflammatory Lesion ◽  
Unknown Etiology ◽  
Low Grade ◽  
Text Search ◽  
Standardized Protocol ◽  
Prevalence Estimates ◽  
Chronic Villitis ◽  
Pathology Reports ◽  
Estimate Prevalence

Introduction Chronic villitis of unknown etiology (VUE) is a chronic inflammatory lesion of the placenta. VUE is hypothesized to result from an alloimmune response or as response to an unidentified infection. Lack of a seasonal trend is thought to support VUE as an alloimmune response, though data on seasonal VUE trends are limited. Methods Data were obtained from a hospital in Chicago, Illinois, from 2011–2016. Placentas sent to pathology were reviewed using a standardized protocol, and VUE cases were identified based on an automated text search of pathology records. We used monthly VUE prevalence estimates to investigate the annual trend, and we used Poisson regression to evaluate seasonal variation in the number of VUE cases. Results There were 79 825 deliveries within the study period. Pathologists evaluated 12 074 placentas and identified 2873 cases of VUE. Regression results indicate that the risk of VUE is 16% to 17% higher in the fall and winter as compared to the summer (fall relative risk [RR]: 1.17, 95% confidence interval [CI]: 1.06–1.29; winter RR: 1.16, 95% CI: 1.05–1.29). Discussion Our results suggest that there may be seasonal variation in VUE prevalence, particularly for low-grade VUE. Future studies should evaluate seasonal variation in a representative sample rather than relying on pathology reports to estimate prevalence.

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