scholarly journals Drop Suspension Final Dosage Form

2020 ◽  
Author(s):  
Keyword(s):  
Dosage Form ◽  
Final Dosage Form

Drug Nanocrystals: A Comprehensive Review with Current Regulatory Guidelines

2020 ◽  
Vol 17 (6) ◽  
pp. 470-482
Author(s):  
Mori Dhaval ◽  
Jalpa Makwana ◽  
Ekta Sakariya ◽  
Kiran Dudhat
Keyword(s):  
Dissolution Rate ◽  
Dosage Form ◽  
Poorly Soluble Drugs ◽  
Comprehensive Review ◽  
Drug Molecules ◽  
Regulatory Guidelines ◽  
Poorly Soluble ◽  
Form Design ◽  
Capsule Suspension ◽  
Final Dosage Form

Drug nanocrystals offer an attractive approach for improving the solubility and dissolution rate of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules. Both methods for manufacturing drug nanocrystals have high industrial acceptability for being simple and easy to scale which is evident from the number of approved products available in the market. Ability to modify multiple aspects of dosage form like bioavailability, release pattern and dosage form requirement along with flexibility in choosing final dosage form starting from the tablet, capsule, suspension to parenteral one, have made nanocrystal technology one of the very promising and adaptable technology for dosage form design.

scholarly journals Establishment of blending control for Hand operated Double Cone Blender

2018 ◽  
Vol 6 (2) ◽  
pp. 30-34
Author(s):  
Bayya Subba Rao ◽  
Anuroop Raveendran ◽  
Ratnakar Baki ◽  
Adithya Jinuka
Keyword(s):  
Uniform Distribution ◽  
Potassium Permanganate ◽  
Dosage Form ◽  
Double Cone ◽  
Geometric Progression ◽  
Blended Powder ◽  
Operation Procedure ◽  
Percent Concentration ◽  
Potent Drug ◽  
Final Dosage Form

In the current study, a fundamental approach is used to establish operation procedure, for a hand operated double cone blender.  Initially, assuming for a potent drug, where in, the strength of the drug is very less in the final dosage form, a one percent concentration of potassium permanganate with respect to final one kilogram of blended powder using starch as diluent was planned.  With a kind of geometric progression method, at a rate of 10 rotations per minute, the final outcome of the uniform distribution of the potassium permanganate was found to be for at least for fourteen hours of rotations, leading to concentration range of potassium permanganate 0.08 ± 0.025 mg per mg of final blended powder.

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