scholarly journals APOC3 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Apoc3 Gene

A Study of APOC3 Gene Polymorphism in Patients of Diabetes Mellitus with Hypertriglyceridemia

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 37-LB
Author(s):  
BIPUL C. KALITA ◽  
RATAN K. KOTOKEY ◽  
SUBHALAKSHMI DAS ◽  
AVISEK CHAKRAVORTY ◽  
HARISH SONI
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Apoc3 Gene

scholarly journals Significant association of APOA5 and APOC3 gene polymorphisms with meat quality traits in Kele pigs

2013 ◽  
Vol 12 (3) ◽  
pp. 3643-3650 ◽  
Author(s):  
Y.T. Hui ◽  
Y.Q. Yang ◽  
R.Y. Liu ◽  
Y.Y. Zhang ◽  
C.J. Xiang ◽  
...  
Keyword(s):  
Meat Quality ◽  
Gene Polymorphisms ◽  
Quality Traits ◽  
Meat Quality Traits ◽  
Apoc3 Gene

P829The impact of APOC3 and APOE gene polymorphisms on response to statin therapy in acute myocardial infarction

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Teterina ◽  
A Geraskin ◽  
P Potapov ◽  
L Babaeva ◽  
A Pisaryuk ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Statin Therapy ◽  
Gene Polymorphisms ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Genetic Studies ◽  
Apoc3 Gene ◽  
Pronounced Reduction

Abstract Background and aim Many genetic studies have been reported about the association between APOE, APOC3 gene polymorphisms and response to statin therapy in myocardial infarction, but results remain controversial. The aim of this study was to investigate the association between SNP rs7412 (APOE), rs2854117 (APOC3), rs2854116 (APOC3) and lipid-lowering effect of atorvastatin and rosuvastatin in patients with myocardial infarction. Methods Polymorphism of genes APOE (rs7412), APOC3 (rs2854117 and rs2854116) was determened. Lipid profile was determined on admission and after 1 year of treatment. Results 78 patients with myocardial infarction treated with maximal tolerated dose of atorvastatin or rosuvastatin were included. More pronounced reduction of lipid levels was associated with of T allele of rs7412 (APOE), p<0,05. ANOVA demonstrated greater low-density lipoprotein and total cholesterol decrease in patients with combination of genes CT/TT (rs7412, APOE) and CC (rs2854117, APOC3) genotypes, CT/TT (rs7412, APOE) and CT (rs2854116, APOC3) genotypes. Conclusion The genetic variants of APOC3 and APOE are useful markers and can be use to predict response to lipid-lowering therapy with statin in myocardial infarction.

scholarly journals Sequence analysis and variant identification at the APOC3 gene locus indicates association of rs5218 with BMI in a sample of Kuwaiti’s

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Zainab H. Malalla ◽  
Ahmad E. Al-Serri ◽  
Huda M. AlAskar ◽  
Wafaa Y. Al-Kandari ◽  
Suzanne A. Al-Bustan
Keyword(s):  
Sequence Analysis ◽  
Genetic Model ◽  
The Novel ◽  
Lipid Levels ◽  
Intron 1 ◽  
Sequence Variations ◽  
Increased Risk ◽  
Apoc3 Gene ◽  
Dominant Genetic Model ◽  
Novel Variant

Abstract Background APOC3 is important in lipid transport and metabolism with limited studies reporting genetic sequence variations in specific ethnic groups. The present study aimed to analyze the full APOC3 sequence among Kuwaiti Arabs and test the association of selected variants with lipid levels and BMI. Methods Variants were identified by Sanger sequencing the entire APOC3 gene in 100 Kuwaiti Arabs. Variants and their genotypes were fully characterized and used to construct haplotype blocks. Four variants (rs5128, rs2854117, rs2070668, KUAPOC3N3 g.5196 A > G) were selected for testing association with serum lipid levels and BMI in a cohort (n = 733). Results APOC3 sequence (4.3 kb) of a Kuwaiti Arab was deposited in Genbank (accession number KJ437193). Forty-two variants including 3 novels were identified including an “A” insertion at genomic positions 116,700,599–116,700,600 (promoter region) and two substitutions in intron 1 at genomic positions 116,700,819 and 116,701,159. Only three variants, (rs5128, rs2854117, and rs2070668) were analyzed for association of which rs5128 showed a trend for association with increased BMI, TG and VLDL levels that was further investigated using multivariate analysis. A significant association of rs5128 with BMI (p <  0.05) was observed following a dominant genetic model with increased risk by an OR of 4.022 (CI: 1.13–14.30). Conclusion The present study is the first to report sequence analysis of APOC3 in an Arab ethnic group. This study supports the inclusion of rs5128 as a marker for assessing genetic risk to dyslipidemia and obesity and the inclusion of the novel variant g.5196 A > G for population stratification of Arabs.

scholarly journals Hypervariable polymorphism in the APOC3 gene

1991 ◽  
Vol 19 (17) ◽  
pp. 4799-4799 ◽  
Author(s):  
S. Bhattacharya ◽  
T.M.E. Wilson ◽  
A.P. Wojciechowski ◽  
C.P. Volpe ◽  
J. Scott
Keyword(s):  
Apoc3 Gene ◽  
Hypervariable Polymorphism

scholarly journals Polymorphism of apolipoprotein C3 (APOC3) gene in children with HIV infection at Dr. Soetomo Hospital, Surabaya, Indonesia

2021 ◽  
Vol 50 (3) ◽  
pp. 424
Author(s):  
Rika Hapsari ◽  
Dominicus Husada ◽  
Leny Kartina ◽  
Sukmawati Basuki
Keyword(s):  
Hiv Infection ◽  
Apolipoprotein C3 ◽  
Apoc3 Gene

scholarly journals Apolipoprotein C-III, n-3 Polyunsaturated Fatty Acids, and “Insulin-Resistant” T−455C APOC3 Gene Polymorphism in Heart Disease Patients: Example of Gene-Diet Interaction

2005 ◽  
Vol 51 (2) ◽  
pp. 360-367 ◽  
Author(s):  
Oliviero Olivieri ◽  
Nicola Martinelli ◽  
Marco Sandri ◽  
Antonella Bassi ◽  
Patrizia Guarini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Heart Disease ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Interactive Effect ◽  
Lipid Lowering ◽  
Apolipoprotein C ◽  
Apoc3 Gene

Abstract Background: Apolipoprotein C-III (apo C-III) is a marker of cardiovascular disease risk associated with triglyceride (TG)-rich lipoproteins. The T−455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apo C-III concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained in fish have well-known apo C-III-lowering properties. Methods: We investigated the possibility of an interactive effect between the APOC3 gene variant and erythrocyte n-3 PUFAs, suitable markers of dietary intake of fatty acids, on apo C-III concentrations in a population of 848 heart disease patients who had coronary angiography. Results: In the population as a whole, apo C-III concentrations were significantly inversely correlated with total erythrocyte PUFAs, but the correlation was not significant when only −455CC homozygous individuals were taken into account. In the total population and in subgroups with the −455TT and −455CT genotypes, the relative proportions of individuals presenting with increased apo C-III (i.e., above the 75th percentile value calculated on the entire population after exclusion of individuals taking lipids-lowering medications) decreased progressively as the n-3 PUFA and docosahexaenoic acid concentrations increased. The opposite situation was observed in the homozygous −455CC subgroup, in whom increasing erythrocyte n-3 PUFA and docosahexaenoic acid concentrations were associated with higher proportions of individuals with high apo C-III. A formal interactive effect between genotype and n-3 PUFAs was confirmed even after adjustment for possible confounding variables [age, sex, body mass index, smoking, coronary artery disease (CAD)/CAD-free status, or use of lipid-lowering medications] by logistic models. Conclusion: Patients homozygous for the −455C APOC3 variant are poorly responsive to the apo C-III-lowering effects of n-3 PUFAs.

N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model

2017 ◽  
Vol 431 (1-2) ◽  
pp. 133-138 ◽  
Author(s):  
Lama Hamadneh ◽  
Luay Al-Essa ◽  
Suhair Hikmat ◽  
Tariq Al-Qirim ◽  
Ghassan Abu Sheikha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Model ◽  
Apoc3 Gene
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