scholarly journals IL18 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Il18 Gene

scholarly journals Polymorphism in the IL18 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women

2008 ◽  
Vol 17 (12) ◽  
pp. 3567-3572 ◽  
Author(s):  
R. T. Palmieri ◽  
M. A. Wilson ◽  
E. S. Iversen ◽  
M. A. Clyde ◽  
B. Calingaert ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
White Women ◽  
Hispanic White ◽  
Il18 Gene

The IL18 gene and Hashimoto thyroiditis in children

2013 ◽  
Vol 74 (1) ◽  
pp. 120-124 ◽  
Author(s):  
Chi-Yu Huang ◽  
Wei-Hsin Ting ◽  
Fu-Sung Lo ◽  
Yi-Lei Wu ◽  
Tzu-Yang Chang ◽  
...  
Keyword(s):  
Hashimoto Thyroiditis ◽  
Il18 Gene

scholarly journals Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus

2009 ◽  
Vol 18 (19) ◽  
pp. 3739-3748 ◽  
Author(s):  
Elena Sánchez ◽  
Rogelio J. Palomino-Morales ◽  
Norberto Ortego-Centeno ◽  
Juan Jiménez-Alonso ◽  
Miguel A. González-Gay ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Association Study ◽  
Lupus Erythematosus ◽  
Gene Variant ◽  
Systemic Lupus ◽  
Il18 Gene

scholarly journals IL18 Gene Variants Influence the Susceptibility to Chagas Disease

2016 ◽  
Vol 10 (3) ◽  
pp. e0004583 ◽  
Author(s):  
Daniel A Leon Rodriguez ◽  
F. David Carmona ◽  
Luis Eduardo Echeverría ◽  
Clara Isabel González ◽  
Javier Martin
Keyword(s):  
Chagas Disease ◽  
Gene Variants ◽  
Il18 Gene

scholarly journals IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias

Blood ◽  
2020 ◽  
Author(s):  
Akash Gupta ◽  
Yu-Dong Fei ◽  
Tae Yun Kim ◽  
An Xie ◽  
Ken Batai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sickle Cell ◽  
Cardiac Fibrosis ◽  
Mononuclear Cells ◽  
Humanized Mouse Model ◽  
Peripheral Blood Mononuclear ◽  
Patients At Risk ◽  
The Right ◽  
Il18 Gene

Previous reports indicate IL18 is a novel candidate gene for diastolic dysfunction in sickle cell disease (SCD)-related cardiomyopathy. We hypothesize that IL-18 mediates the development of cardiomyopathy and ventricular tachycardia (VT) in SCD. Compared to control (CTR) mice, a "humanized" mouse model of SCD exhibited increased cardiac fibrosis, prolonged action potential duration (APD), higher VT inducibility in vivo, higher cardiac NFκB phosphorylation and circulating IL-18 levels, as well as reduced voltage-gated potassium channel expression, translating to reduced outward potassium current (Ito) in isolated cardiomyocytes. IL-18 administration to isolated mice hearts resulted in VTs, originating from the right ventricle, and further reduced Ito in SCD mice cardiomyocytes. Sustained IL-18 inhibition via IL-18 binding protein resulted in decreased cardiac fibrosis and NFκB phosphorylation, improved diastolic function, normalized electrical remodeling and attenuated IL-18-mediated VT in SCD mice. Patients with SCD and either myocardial fibrosis or increased QTc displayed greater IL18 gene expression in peripheral blood mononuclear cells (PBMC), with QTc strongly correlated with plasma IL-18 levels. PBMC-derived IL18 gene expression was increased in non-surviving over surviving subjects. IL-18 is a mediator of sickle cell cardiomyopathy and VT in mice and a novel therapeutic target in patients at risk for sudden death.

Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema

2005 ◽  
Vol 115 (4) ◽  
pp. 828-833 ◽  
Author(s):  
Natalija Novak ◽  
Susanne Kruse ◽  
Jana Potreck ◽  
Laura Maintz ◽  
Claudia Jenneck ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Atopic Eczema ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Il18 Gene

scholarly journals IL16 and IL18 gene polymorphisms in women with gestational diabetes

2017 ◽  
Vol 88 (5) ◽  
pp. 249-254 ◽  
Author(s):  
Maciej Tarnowski ◽  
Alicja Wieczorek ◽  
Violetta Dziedziejko ◽  
Krzysztof Safranow ◽  
Przemysław Ustianowski ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Gene Polymorphisms ◽  
Il18 Gene

scholarly journals IL-18 Gene Polymorphisms Impacts on Its Serum Levels in Prostate Cancer Iraqi Patients

2019 ◽  
pp. 1188-1196
Author(s):  
Mahmmod Talib Shkaaer ◽  
Nawal Mohammed Utba
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Gene Promoter ◽  
Serum Levels ◽  
Control Group ◽  
Arab Population ◽  
Prostate Cancer Development ◽  
Age Range ◽  
And Control ◽  
Il18 Gene

Prostate cancer is one of the most common types of cancer in men. A total of 110 Iraqi Arab individuals were included in this study; 60 individuals of them had prostate cancer with increased levels of TPSA (patients group); their age range 52-90 years. They were referred for diagnosis and treatment to the National Al-Amal Hospital for oncology in Baghdad during the period from July 2017 to October 2017. While the other 50 apparently healthy subjects were the control group, their age range similar to patients group. Sera and blood samples were collected from all patients and controls than used to assess for the level of IL-18 and DNA extraction, respectively. The polymorphisms were analyzed using polymerase chain reaction-single specific primer (PCR-SSP), at the position -137 G\C (rs187238) in the promoter of IL18 gene. The genetic polymorphism of the IL18 gene promoter -137G/C (rs187238) was determined and presented with three genotypes (GG, GC, and CC) in prostate cancer patients and controls. Testing for Hardy-Weinberg (H-W) equilibrium revealed that Prostate cancer patients showed insignificant variation in the distribution of IL-18 -137 genotypes (P> 0.05). While the control samples showed significant variation (p ≤0.05) between the observed and expected. Comparing patients with controls indicated that IL-18-137 alleles or genotypes showed no association with the risk of prostate cancer development in Iraqi Arab population or protection against them. Serum level of IL-18 was highly significant (P ≤ 0.001) increased in patients compared to control. The IL-18 serum levels differences in GG and GC genotypes was significant (p <0.05) between patients and control. While there were no significant differences between the three IL-18 -137 genotypes inpatient or in controls.

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