Benign Lymph Node Neoplasm

2020 ◽  
Author(s):  
Keyword(s):  
Lymph Node ◽  
Benign Lymph Node

Fine-Needle Aspiration Effects on Benign Lymph Node Histology

1985 ◽  
Vol 133 (2) ◽  
pp. 350-350
Author(s):  
F.G. Behm ◽  
G.J. O’Dowd ◽  
W.J. Frable
Keyword(s):  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Lymph Node Histology ◽  
Benign Lymph Node

scholarly journals Normative data for flow cytometry immunophenotyping of benign lymph nodes sampled by surgical biopsy

2017 ◽  
Vol 71 (2) ◽  
pp. 174-179 ◽  
Author(s):  
Gregory David Scott ◽  
Susan K Atwater ◽  
Dita A Gratzinger
Keyword(s):  
Flow Cytometry ◽  
Lymph Node ◽  
T Cell ◽  
Lymph Nodes ◽  
Inflammatory Disease ◽  
Clinical History ◽  
Surgical Biopsy ◽  
Data Set ◽  
Flow Cytometry Data ◽  
Benign Lymph Node

AimsTo create clinically relevant normative flow cytometry data for understudied benign lymph nodes and characterise outliers.MethodsClinical, histological and flow cytometry data were collected and distributions summarised for 380 benign lymph node excisional biopsies. Outliers for kappa:lambda light chain ratio, CD10:CD19 coexpression, CD5:CD19 coexpression, CD4:CD8 ratios and CD7 loss were summarised for histological pattern, concomitant diseases and follow-up course.ResultsWe generated the largest data set of benign lymph node immunophenotypes by an order of magnitude. B and T cell antigen outliers often had background immunosuppression or inflammatory disease but did not subsequently develop lymphoma.ConclusionsDiagnostic immunophenotyping data from benign lymph nodes provide normative ranges for clinical use. Outliers raising suspicion for B or T cell lymphoma are not infrequent (26% of benign lymph nodes). Caution is indicated when interpreting outliers in the absence of excisional biopsy or clinical history, particularly in patients with concomitant immunosuppression or inflammatory disease.

Castleman Disease In Children: Diagnosis and Treatment

2020 ◽  
Author(s):  
Hung Dinh Viet
Keyword(s):  
Lymph Node ◽  
Postoperative Period ◽  
Case Reports ◽  
Abdominal Mass ◽  
Clinical Manifestations ◽  
Castleman Disease ◽  
Results Of Treatment ◽  
Benign Lymph Node ◽  
Lymph Node Hyperplasia

Background: We describe the experiences in diagnosis and results of treatment in pediatric Castleman disease. Method: Serial case reports. Result: From 2016 to 2019, we had 7 cases of pediatric Castleman disease: 3 boys and 4 girl. The median age at diagnosis was 147 months (121-173 months). Clinical manifestations were found in five cases. They were all unicentric Castleman disease (6 abdominal mass, one left infraclavicular mass). All patients were operated with postoperative period uneventful. The median time of postoperative follow up was 22.7 months (11-53 months) with no signs of relapse. Conclusions: Pediatric Castleman disease is a rare benign lymph node hyperplasia, it can be localised or disseminated. Operation is the treatment of choice for localised Castleman disease.

Benign lymph node

2020 ◽  
pp. 159-170
Author(s):  
Amer Wahed ◽  
Andres Quesada ◽  
Amitava Dasgupta
Keyword(s):  
Lymph Node ◽  
Benign Lymph Node

scholarly journals Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma

Blood ◽  
1991 ◽  
Vol 77 (7) ◽  
pp. 1527-1533 ◽  
Author(s):  
D Shibata ◽  
LM Weiss ◽  
BN Nathwani ◽  
RK Brynes ◽  
AM Levine
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Normal Individuals ◽  
Non Hodgkin's Lymphoma ◽  
Immunodeficiency Virus ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Benign Lymph Node

Abstract Individuals infected with the human immunodeficiency virus (HIV) have an increased incidence of high-grade B-cell lymphoma. In many instances, these lymphomas contain Epstein-Barr viral (EBV) genomes. To investigate the role of EBV in development of HIV-related lymphoma, benign fixed lymph node biopsies from normal individuals and HIV- infected individuals with persistent generalized lymphadenopathy (PGL) were analyzed for EBV sequences by polymerase chain reaction and in situ DNA hybridization techniques. EBV DNA was not detected in any of 16 benign lymph node biopsies from normal individuals, but could be detected from 13 of 35 PGL biopsies. The EBV-infected cells were present in both follicular and interfollicular areas and in both small and large lymphoid cells. The presence of detectable amounts of EBV DNA in the 13 PGL biopsies was associated with an increased incidence of concurrent lymphoma at another site (n = 3) or development of lymphoma in time (n = 2). In contrast, only 1 of 22 individuals with EBV- negative PGL biopsies developed lymphoma in time (P less than .05). EBV was detected in all five lymphomas in which tissue was available for subsequent analysis, including the lymphoma that developed in the individual without EBV in his previous PGL biopsy. These findings support the hypothesis that EBV plays a role in development of some HIV- related lymphomas. Detectable EBV lymphoproliferations occur in a few PGL biopsies and are associated with a significant risk of EBV DNA- positive non-Hodgkin's lymphoma.

Phenytoin-Induced Lymphadenopathy

1983 ◽  
Vol 17 (6) ◽  
pp. 460-462 ◽  
Author(s):  
Terry L. Schwinghammer ◽  
Denise L. Howrie
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Cytotoxic Drugs ◽  
Appropriate Treatment ◽  
Erroneous Diagnosis ◽  
Symptom Complex ◽  
Benign Lymph Node ◽  
Lymph Node Hyperplasia

Various lymph node abnormalities have been associated with phenytoin therapy. Four distinct categories of lymphadenopathy have been described: lymphoid hyperplasia, pseudolymphoma, pseudo-pseudolymphoma, and lymphoma. These presentations vary from a benign symptom complex, with enlarged lymph nodes, that is reversible upon drug discontinuance to a true malignant lymphoma that is progressive and ultimately fatal. Benign lymph node hyperplasia and pseudolymphoma may result in erroneous diagnosis and treatment of malignant lymphoma if phenytoin-associated lymphadenopathy has not been considered. We describe a patient who developed enlarged inguinal lymph nodes while receiving chronic phenytoin therapy. An initial diagnosis of malignant lymphoma was made, and recurrent hospitalizations and treatment with cytotoxic drugs ensued. Repeat biopsy, as well as reexamination of the removed nodes, later revealed phenytoin-associated hyperplasia. Patients who develop enlarged lymph nodes while receiving phenytoin should be evaluated carefully so that phenytoin-induced lymphadenopathy may be differentiated from true malignant lymphoma and appropriate treatment may be given.

scholarly journals Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma

Blood ◽  
1991 ◽  
Vol 77 (7) ◽  
pp. 1527-1533 ◽  
Author(s):  
D Shibata ◽  
LM Weiss ◽  
BN Nathwani ◽  
RK Brynes ◽  
AM Levine
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Normal Individuals ◽  
Non Hodgkin's Lymphoma ◽  
Immunodeficiency Virus ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Benign Lymph Node

Individuals infected with the human immunodeficiency virus (HIV) have an increased incidence of high-grade B-cell lymphoma. In many instances, these lymphomas contain Epstein-Barr viral (EBV) genomes. To investigate the role of EBV in development of HIV-related lymphoma, benign fixed lymph node biopsies from normal individuals and HIV- infected individuals with persistent generalized lymphadenopathy (PGL) were analyzed for EBV sequences by polymerase chain reaction and in situ DNA hybridization techniques. EBV DNA was not detected in any of 16 benign lymph node biopsies from normal individuals, but could be detected from 13 of 35 PGL biopsies. The EBV-infected cells were present in both follicular and interfollicular areas and in both small and large lymphoid cells. The presence of detectable amounts of EBV DNA in the 13 PGL biopsies was associated with an increased incidence of concurrent lymphoma at another site (n = 3) or development of lymphoma in time (n = 2). In contrast, only 1 of 22 individuals with EBV- negative PGL biopsies developed lymphoma in time (P less than .05). EBV was detected in all five lymphomas in which tissue was available for subsequent analysis, including the lymphoma that developed in the individual without EBV in his previous PGL biopsy. These findings support the hypothesis that EBV plays a role in development of some HIV- related lymphomas. Detectable EBV lymphoproliferations occur in a few PGL biopsies and are associated with a significant risk of EBV DNA- positive non-Hodgkin's lymphoma.

Ectopic Decidua of Pelvic Lymph Nodes: A Potential Diagnostic Pitfall

2005 ◽  
Vol 129 (5) ◽  
pp. e117-e120 ◽  
Author(s):  
Debbie C. Wu ◽  
Sharon Hirschowitz ◽  
Sathima Natarajan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Pregnant Woman ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Metastatic Carcinoma ◽  
Diagnostic Pitfall ◽  
Benign Lymph Node

Abstract Ectopic decidua is one of several benign lymph node inclusions that have been increasingly documented in the literature, most often in postmortem examinations of pregnant woman and recently in pregnant women with cervical squamous cell carcinoma. Although lacking clinical significance of its own, the major diagnostic implication would be misdiagnosis as metastatic carcinoma in the lymph node. Intraoperative frozen sections are often performed prior to radical hysterectomy, leading to a potential alteration of therapy if metastatic carcinoma is identified in the lymph nodes. We report such a case of a pregnant woman with cervical squamous cell carcinoma requiring lymphadenectomy and hysterectomy, in which the intraoperative frozen section of a pelvic lymph node with ectopic decidual change was mistakenly identified as metastatic carcinoma. Its histologic resemblance to carcinoma and location within subcapsular sinuses, compounded with the fact that ectopic lymph node decidua is not commonly seen in routine practice, can lead to this diagnostic pitfall. We review the literature regarding ectopic decidua, its presence in lymph nodes, and its pathogenesis, as well as review the literature on benign lymph node inclusions.

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