scholarly journals FLT3 Tyrosine Kinase Domain Mutation Negative

2020 ◽  
Author(s):  
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Kinase Domain Mutation

Reactivating PP2A by FTY720 as a Novel therapy for AML with C-KIT tyrosine kinase domain mutation

2012 ◽  
Vol 113 (4) ◽  
pp. 1314-1322 ◽  
Author(s):  
Yan Yang ◽  
Qing Huang ◽  
Yanjun Lu ◽  
Xiaoqing Li ◽  
Shiang Huang
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Novel Therapy ◽  
Kinase Domain Mutation

Analysis of EGFR Gene Amplification, Protein Over-expression and Tyrosine Kinase Domain Mutation in Recurrent Glioblastoma

2008 ◽  
Vol 15 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Judit Toth ◽  
Kristof Egervari ◽  
Almos Klekner ◽  
Laszlo Bognar ◽  
Janos Szanto ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Gene Amplification ◽  
Kinase Domain ◽  
Recurrent Glioblastoma ◽  
Tyrosine Kinase Domain ◽  
Egfr Gene ◽  
Over Expression ◽  
Kinase Domain Mutation

Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia

2019 ◽  
Vol 110 (5) ◽  
pp. 566-574 ◽  
Author(s):  
Masahiro Sakaguchi ◽  
Hiroki Yamaguchi ◽  
Marika Kuboyama ◽  
Yuho Najima ◽  
Kensuke Usuki ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Tyrosine Kinase ◽  
Myeloid Leukemia ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Kinase Domain Mutation ◽  
Acute Myeloid

NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene

Diabetes ◽  
1992 ◽  
Vol 41 (4) ◽  
pp. 521-526 ◽  
Author(s):  
S. Cocozza ◽  
A. Porcellini ◽  
G. Riccardi ◽  
A. Monticelli ◽  
G. Condorelli ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Receptor Gene ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Insulin Receptor Gene

scholarly journals Characterization of Atypical Protein Tyrosine Kinase (PTK) Genes and Their Role in Abiotic Stress Response in Rice

Plants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 664
Author(s):  
Allimuthu Elangovan ◽  
Monika Dalal ◽  
Gopinathan Kumar Krishna ◽  
Sellathdurai Devika ◽  
Ranjeet Ranjan Kumar ◽  
...  
Keyword(s):  
Abiotic Stress ◽  
Stress Response ◽  
Tyrosine Kinase ◽  
Tyrosine Phosphorylation ◽  
Rice Genome ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Protein Tyrosine ◽  
Dual Specificity ◽  
Submergence Stress

Tyrosine phosphorylation constitutes up to 5% of the total phophoproteome. However, only limited studies are available on protein tyrosine kinases (PTKs) that catalyze protein tyrosine phosphorylation in plants. In this study, domain analysis of the 27 annotated PTK genes in rice genome led to the identification of 18 PTKs with tyrosine kinase domain. The kinase domain of rice PTKs shared high homology with that of dual specificity kinase BRASSINOSTEROID-INSENSITIVE 1 (BRI1) of Arabidopsis. In phylogenetic analysis, rice PTKs clustered with receptor-like cytoplasmic kinases-VII (RLCKs-VII) of Arabidopsis. mRNAseq analysis using Genevestigator revealed that rice PTKs except PTK9 and PTK16 express at moderate to high level in most tissues. PTK16 expression was highly abundant in panicle at flowering stage. mRNAseq data analysis led to the identification of drought, heat, salt, and submergence stress regulated PTK genes in rice. PTK14 was upregulated under all stresses. qRT-PCR analysis also showed that all PTKs except PTK10 were significantly upregulated in root under osmotic stress. Tissue specificity and abiotic stress mediated differential regulation of PTKs suggest their potential role in development and stress response of rice. The candidate dual specificity PTKs identified in this study paves way for molecular analysis of tyrosine phosphorylation in rice.

scholarly journals Directed Discovery of Agents Targeting the Met Tyrosine Kinase Domain by Virtual Screening

2009 ◽  
Vol 52 (4) ◽  
pp. 943-951 ◽  
Author(s):  
Megan L. Peach ◽  
Nelly Tan ◽  
Sarah J. Choyke ◽  
Alessio Giubellino ◽  
Gagani Athauda ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Tyrosine Kinase ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain

A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia

1995 ◽  
Vol 10 (3) ◽  
pp. 357-359 ◽  
Author(s):  
Gary A. Bellus ◽  
Iain McIntosh ◽  
E. Anne Smith ◽  
Arthur S. Aylsworth ◽  
Ilkka Kaitila ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Kinase Domain ◽  
Recurrent Mutation ◽  
Tyrosine Kinase Domain ◽  
Fibroblast Growth

Expanding the search for significant EGFR mutations in NSCLC outside of the tyrosine kinase domain with next-generation sequencing

2017 ◽  
Vol 34 (7) ◽  
Author(s):  
Matthew K. Stein ◽  
Lindsay Morris ◽  
Jennifer L. Sullivan ◽  
Moon Fenton ◽  
Ari VanderWalde ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Tyrosine Kinase ◽  
Kinase Domain ◽  
Egfr Mutations ◽  
Tyrosine Kinase Domain ◽  
Next Generation ◽  
Generation Sequencing
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