scholarly journals Meningeal Tuberculosis

2020 ◽  
Author(s):  
Keyword(s):  
Meningeal Tuberculosis

scholarly journals Meningeal TB in a 39-Year-Old Male Presenting with Headache

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Jason Selinger ◽  
Thar El Baage
Keyword(s):  
United States ◽  
Alcohol Abuse ◽  
Cerebral Spinal Fluid ◽  
The United States ◽  
Spinal Fluid ◽  
History Of ◽  
Developed World ◽  
Meningeal Tuberculosis

Meningeal tuberculosis is rare in the developed world, with only 92 cases of meningeal TB reported in the United States in 2014 according to the CDC (CDC, 2015). We describe the case of a 39-year-old male with a history of alcohol abuse, whose cerebral spinal fluid acid fast smears confirmed TB only weeks after his death. His only initial presenting symptom was headache, and his condition declined rapidly during his hospitalization.

scholarly journals Nested-PCR using MPB64 fragment improves the diagnosis of pleural and meningeal tuberculosis

2000 ◽  
Vol 33 (3) ◽  
pp. 253-257 ◽  
Author(s):  
Luiz C. Martins ◽  
Ilma A. Paschoal ◽  
Angela Von Nowakonski ◽  
Silvana A.B. Silva ◽  
Fernando F. Costa ◽  
...  
Keyword(s):  
Predictive Value ◽  
Gold Standard ◽  
Positive Culture ◽  
High Specificity ◽  
Pcr Assay ◽  
Tuberculous Pleural Effusion ◽  
Tuberculosis Diagnosis ◽  
Pcr Techniques ◽  
Meningeal Tuberculosis ◽  
Gold Standards

Fluids in which Mycobacterium tuberculosis are seldom found, such as pleural and cerebrospinal liquids, are good candidates to be studied using PCR techniques. We detail our experience with a PCR assay applied to pleural and cerebrospinal fluids using the primer MPB64. Seventy three specimens were analyzed: 30 pleural fluids (PF), 26 pleural biopsies (PB) and 17 cerebrospinal fluids (CSF). The gold standard for the diagnosis of tuberculous meningitis was the positive culture for M. tuberculosis in CSF. Tuberculous pleural effusion was diagnosed when cultures of PF and/or PB were positive for M. tuberculosis, or the PB histology showed granulomas. Our results, compared to the gold standards employed, showed a sensitivity of 70%, specificity of 88%, positive predictive value of 82% and negative predictive value of 80%. The high specificity of the MPB64 fragment while still retaining a good sensitivity makes it very well suited for pleural and cerebrospinal tuberculosis diagnosis.

scholarly journals Relationship between Mycobacterium tuberculosis Genotype and the Clinical Phenotype of Pulmonary and Meningeal Tuberculosis

2008 ◽  
Vol 46 (4) ◽  
pp. 1363-1368 ◽  
Author(s):  
G. Thwaites ◽  
M. Caws ◽  
T. T. H. Chau ◽  
A. D'Sa ◽  
N. T. N. Lan ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Phenotype ◽  
Meningeal Tuberculosis

scholarly journals Stroke in a patient with tuberculous meningitis and HIV infection

2013 ◽  
Vol 5 (1) ◽  
pp. e2013017 ◽  
Author(s):  
Maria Bruna Pasticci ◽  
Maurizio Paciaroni ◽  
Piero Floridi ◽  
Enisia Cecchini ◽  
Franco Baldelli
Keyword(s):  
Risk Factors ◽  
Differential Diagnosis ◽  
Mycobacterium Tuberculosis ◽  
Side Effects ◽  
Hiv Infection ◽  
Tuberculous Meningitis ◽  
Clinical Manifestations ◽  
Treatment Needs ◽  
Caucasian Female ◽  
Meningeal Tuberculosis

Abstract. Tuberculous meningitis (TBM) is a devastating disease. TBM occurs more commonly in HIV infected patients. The influence of HIV co-infection on clinical manifestations and outcome of TBM is not well defined. Yet, some differences have been observed and stroke has been recorded to occur more frequently. This study reports on an HIV infected Caucasian female with lung, meningeal tuberculosis and stroke due to a cortical sub-cortical ischemic lesion.TBM was documented in the absence of neurologic symptoms. At the same time, miliary lung TB caused by multi-susceptible Mycobacterium tuberculosis was diagnosed. Anti-TB therapy consisting of a combination of four drugs was administered. The patient improved and was discharged five weeks later. In conclusion, TBM and multiple underling pathologies including HIV infection, as well as other risk factors can lead to a greater risk of stroke. Moreover, drug interactions and their side effects add levels of complexity. TBM must be included in the differential diagnosis of HIV infected patients with stroke and TBM treatment needs be started as soon as possible before the onset of vasculopathy.

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