scholarly journals 60S Acidic Ribosomal Protein P0

2020 ◽  
Author(s):  
Keyword(s):  
Ribosomal Protein ◽  
Ribosomal Protein P0 ◽  
Acidic Ribosomal Protein

scholarly journals The Leishmania infantum Acidic Ribosomal Protein P0 Administered as a DNA Vaccine Confers Protective Immunity to Leishmania major Infection in BALB/c Mice

2003 ◽  
Vol 71 (11) ◽  
pp. 6562-6572 ◽  
Author(s):  
Salvador Iborra ◽  
Manuel Soto ◽  
Javier Carrión ◽  
Ana Nieto ◽  
Edgar Fernández ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Leishmania Infantum ◽  
Leishmania Major ◽  
Parasite Burden ◽  
Immunological Response ◽  
Humoral Response ◽  
Ifn Γ ◽  
Immunogenic Properties ◽  
Ribosomal Protein P0 ◽  
Acidic Ribosomal Protein

ABSTRACT In this study, we examined the immunogenic properties of the Leishmania infantum acidic ribosomal protein P0 (LiP0) in the BALB/c mouse model. The humoral and cellular responses induced by the administration of the LiP0 antigen, either as soluble recombinant LiP0 (rLiP0) or as a plasmid DNA formulation (pcDNA3-LiP0), were determined. Also, the immunological response associated with a prime-boost strategy, consisting of immunization with pcDNA3-LiP0 followed by a boost with rLiP0, was assayed. Immunization with rLiP0 induced a predominant Th2-like humoral response, but no anti-LiP0 antibodies were induced after immunization with pcDNA3-LiP0, whereas a strong humoral response consisting of a mixed immunoglobulin G2a (IgG2a)-IgG1 isotype profile was induced in mice immunized with the prime-boost regime. For all three immunization protocols, rLiP0-stimulated production of gamma interferon (IFN-γ) in both splenocytes and lymph node cells from immunized mice was observed. However, it was only when mice were immunized with pcDNA3-LiP0 that noticeable protection against L. major infection was achieved, as determined by both lesion development and parasite burden. Immunization of mice with LiP0-DNA primes both CD4+ and CD8+ T cells, which, with the L. major challenge, were boosted to produce significant levels of IL-12-dependent, antigen-specific IFN-γ. Taken together, these data indicate that genetic vaccination with LiP0 induces protective immunological effector mechanisms, yet the immunological response elicited by LiP0 is not sufficient to keep the infection from progressing.

High efficacy of a 20 amino acid peptide of the acidic ribosomal protein P0 against the cattle tick, Rhipicephalus microplus

2015 ◽  
Vol 6 (4) ◽  
pp. 530-537 ◽  
Author(s):  
Alina Rodríguez-Mallon ◽  
Pedro E. Encinosa ◽  
Lídice Méndez-Pérez ◽  
Yamil Bello ◽  
Rafmary Rodríguez Fernández ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ribosomal Protein ◽  
Rhipicephalus Microplus ◽  
Cattle Tick ◽  
High Efficacy ◽  
Amino Acid Peptide ◽  
Ribosomal Protein P0 ◽  
Acidic Ribosomal Protein

scholarly journals Nucleotide sequence of a cDNA encoding ribosomal protein P0 inDictyostelium discoideum:

1991 ◽  
Vol 19 (6) ◽  
pp. 1342-1342 ◽  
Author(s):  
Jesús Prieto ◽  
Elena Candel ◽  
Antonio Coloma
Keyword(s):  
Nucleotide Sequence ◽  
Ribosomal Protein ◽  
Ribosomal Protein P0

scholarly journals Mutation in P0, a Dual Function Ribosomal Protein/Apurinic/Apyrimidinic Endonuclease, Modifies Gene Expression and Position Effect Variegation in Drosophila

Genetics ◽  
1998 ◽  
Vol 150 (4) ◽  
pp. 1487-1495
Author(s):  
Maxim V Frolov ◽  
James A Birchler
Keyword(s):  
Gene Expression ◽  
Ribosomal Protein ◽  
Position Effect ◽  
P Element ◽  
Dual Function ◽  
Insertion Mutant ◽  
Position Effect Variegation ◽  
Element Insertion ◽  
Effect Variegation ◽  
Ribosomal Protein P0

Abstract In a search for modifiers of gene expression with the white eye color gene as a target, a third chromosomal P-element insertion mutant l(3)01544 has been identified that exhibits a strong pigment increase in a white-apricot background. Molecular analysis shows that the P-element insertion is found in the first intron of the gene surrounding the insertion site. Sequencing both the cDNA and genomic fragments revealed that the identified gene is identical to one encoding ribosomal protein P0/apurinic/apyrimidinic endonuclease. The P-element-induced mutation, l(3)01544, affects the steady-state level of white transcripts and transcripts of some other genes. In addition, l(3)01544 suppresses the variegated phenotypes of In(1)wm4h and In(1)y3P, suggesting a potential involvement of the P0 protein in modifying position effect variegation. The revertant generated by the precise excision of the P element has lost all mutant phenotypes. Recent work revealed that Drosophila ribosomal protein P0 contains an apurinic/apyrimidinic endonuclease activity. Our results suggest that this multifunctional protein is also involved in regulation of gene expression in Drosophila.

Purification and partial characterization of an acidic ribosomal protein kinase from maize

1995 ◽  
Vol 94 (4) ◽  
pp. 715-721
Author(s):  
Gabriela Sepulveda ◽  
Raul Aguilar ◽  
Estela Sanchez de Jimenez
Keyword(s):  
Protein Kinase ◽  
Ribosomal Protein ◽  
Partial Characterization ◽  
Acidic Ribosomal Protein
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