scholarly journals Astrocyte Swelling And Vacuolation

2020 ◽  
Author(s):  
Keyword(s):  
Astrocyte Swelling

scholarly journals Astrocyte swelling leads to membrane unfolding, not membrane insertion

2006 ◽  
Vol 99 (2) ◽  
pp. 514-523 ◽  
Author(s):  
Tina Pangršič ◽  
Maja Potokar ◽  
Philip G. Haydon ◽  
Robert Zorec ◽  
Marko Kreft
Keyword(s):  
Membrane Insertion ◽  
Astrocyte Swelling

scholarly journals SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

Glia ◽  
2017 ◽  
Vol 66 (1) ◽  
pp. 108-125 ◽  
Author(s):  
Jesse A. Stokum ◽  
Min S. Kwon ◽  
Seung K. Woo ◽  
Orest Tsymbalyuk ◽  
Rudi Vennekens ◽  
...  
Keyword(s):  
Astrocyte Swelling

scholarly journals Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma

Glia ◽  
2016 ◽  
pp. n/a-n/a ◽  
Author(s):  
Nina Vardjan ◽  
Anemari Horvat ◽  
Jamie E. Anderson ◽  
Dou Yu ◽  
Deborah Croom ◽  
...  
Keyword(s):  
Astrocyte Swelling ◽  
Adrenergic Activation

scholarly journals Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling

2019 ◽  
Vol 20 (2) ◽  
pp. 330 ◽  
Author(s):  
Audrey Lafrenaye ◽  
J. Simard
Keyword(s):  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Predictors Of Outcome ◽  
Cell Type ◽  
Brain Swelling ◽  
Astrocyte Swelling ◽  
Health And Disease ◽  
The One ◽  
The Brain ◽  
Cellular Swelling

Brain swelling is one of the most robust predictors of outcome following brain injury, including ischemic, traumatic, hemorrhagic, metabolic or other injury. Depending on the specific type of insult, brain swelling can arise from the combined space-occupying effects of extravasated blood, extracellular edema fluid, cellular swelling, vascular engorgement and hydrocephalus. Of these, arguably the least well appreciated is cellular swelling. Here, we explore current knowledge regarding swelling of astrocytes, the most abundant cell type in the brain, and the one most likely to contribute to pathological brain swelling. We review the major molecular mechanisms identified to date that contribute to or mitigate astrocyte swelling via ion transport, and we touch upon the implications of astrocyte swelling in health and disease.

Suppression of ammonia-induced astrocyte swelling by cyclosporin A

2003 ◽  
Vol 74 (6) ◽  
pp. 891-897 ◽  
Author(s):  
K.V. Rama Rao ◽  
M. Chen ◽  
J.M. Simard ◽  
M.D. Norenberg
Keyword(s):  
Cyclosporin A ◽  
Astrocyte Swelling

scholarly journals Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance

2011 ◽  
Vol 301 (1) ◽  
pp. C204-C212 ◽  
Author(s):  
Jennifer M. Rutkowsky ◽  
Breanna K. Wallace ◽  
Phyllis M. Wise ◽  
Martha E. O'Donnell
Keyword(s):  
Ischemic Stroke ◽  
Cell Volume ◽  
Cerebral Edema ◽  
Glucose Deprivation ◽  
Aquaporin 4 ◽  
Oxygen Glucose Deprivation ◽  
Protein Abundance ◽  
Astrocyte Swelling ◽  
Aqp4 Protein ◽  
Stimulation Of

In the early hours of ischemic stroke, cerebral edema forms as Na, Cl, and water are secreted across the blood-brain barrier (BBB) and astrocytes swell. We have shown previously that ischemic factors, including hypoxia, aglycemia, and arginine vasopressin (AVP), stimulate BBB Na-K-Cl cotransporter (NKCC) and Na/H exchanger (NHE) activities and that inhibiting NKCC and/or NHE by intravenous bumetanide and/or HOE-642 reduces edema and infarct in a rat model of ischemic stroke. Estradiol also reduces edema and infarct in this model and abolishes ischemic factor stimulation of BBB NKCC and NHE. There is evidence that NKCC and NHE also participate in ischemia-induced swelling of astrocytes. However, little is known about estradiol effects on astrocyte cell volume. In this study, we evaluated the effects of AVP (100 nM), hypoxia (7.5% O2), aglycemia, hypoxia (2%)/aglycemia [oxygen glucose deprivation (OGD)], and estradiol (1–100 nM) on astrocyte cell volume using 3- O-methyl-d-[3H]glucose equilibration methods. We found that AVP, hypoxia, aglycemia, and OGD (30 min to 5 h) each significantly increased astrocyte cell volume, and that estradiol (30–180 min) abolished swelling induced by AVP or hypoxia, but not by aglycemia or OGD. Bumetanide and/or HOE-642 also abolished swelling induced by AVP but not aglycemia. Abundance of aquaporin-4, known to participate in ischemia-induced astrocyte swelling, was significantly reduced following 7-day but not 2- or 3-h estradiol exposures. Our findings suggest that hypoxia, aglycemia, and AVP each contribute to ischemia-induced astrocyte swelling, and that the edema-attenuating effects of estradiol include reduction of hypoxia- and AVP-induced astrocyte swelling and also reduction of aquaporin-4 abundance.

Involvement of second messengers and protein phosphorylation in astrocyte swelling

1992 ◽  
Vol 70 (S1) ◽  
pp. S362-S366 ◽  
Author(s):  
A. S. Bender ◽  
J. T. Neary ◽  
M. D. Norenberg
Keyword(s):  
Cyclic Amp ◽  
Protein Phosphorylation ◽  
Volume Regulation ◽  
Inositol Phosphates ◽  
Inositol Phosphate ◽  
Second Messengers ◽  
Astrocyte Swelling ◽  
Regulatory Processes ◽  
Intracellular Signals ◽  
Dependent Protein

In a hypoosmotic model of astrocyte swelling, we found that Ca2+ and intracellular signals such as diacylglycerol and inositol phosphate, as well as protein phosphorylation systems, are implicated in the generation and (or) modulation of volume regulatory processes. Cyclic AMP, which also has a significant effect on astrocyte volume regulation, in addition influences some of these second messengers.Key words: astrocyte, Ca2+-dependent protein kinases, Ca2+ influx, cell volume, cyclic AMP, inositol phosphates, protein phosphorylation.

scholarly journals Sulfonylurea Receptor 1 Contributes to the Astrocyte Swelling and Brain Edema in Acute Liver Failure

2014 ◽  
Vol 5 (1) ◽  
pp. 28-37 ◽  
Author(s):  
A. R. Jayakumar ◽  
V. Valdes ◽  
X. Y. Tong ◽  
N. Shamaladevi ◽  
W. Gonzalez ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Brain Edema ◽  
Sulfonylurea Receptor ◽  
Astrocyte Swelling ◽  
Sulfonylurea Receptor 1

scholarly journals Activation of NF-κB Mediates Astrocyte Swelling and Brain Edema in Traumatic Brain Injury

2014 ◽  
Vol 31 (14) ◽  
pp. 1249-1257 ◽  
Author(s):  
Arumugam R. Jayakumar ◽  
Xiao Y. Tong ◽  
Roberto Ruiz-Cordero ◽  
Amade Bregy ◽  
John R. Bethea ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Astrocyte Swelling
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