scholarly journals Negative Skin Test

2020 ◽  
Author(s):  
Keyword(s):  
Skin Test ◽  
Negative Skin Test

scholarly journals Grade IV perioperative anaphylaxis to atracurium despite a previous negative skin test

2020 ◽  
Vol 8 (7) ◽  
pp. 2445-2447
Author(s):  
Aurélie Gouel-Chéron ◽  
Catherine Neukirch ◽  
Sylvie Chollet-Martin ◽  
Dan Longrois ◽  
Pascale Nicaise-Roland ◽  
...  
Keyword(s):  
Skin Test ◽  
Negative Skin Test

scholarly journals 357 Tear IL-4 is Decreased in Allergic Conjunctivitis Patients with Negative Skin Test After Dialyzable Leukocyte Extracts Treatment

2012 ◽  
Vol 5 ◽  
pp. S114-S115
Author(s):  
Gustavo Aguilar-Velazquez ◽  
Concepcion Santacruz ◽  
Pedro M Hernandez ◽  
Raul Chavez ◽  
Sergio Estrada-Parra ◽  
...  
Keyword(s):  
Skin Test ◽  
Allergic Conjunctivitis ◽  
Negative Skin Test

scholarly journals Cephalosporin Induced Disulfiram-Like Reaction: A Retrospective Review of 78 Cases

2014 ◽  
Vol 99 (2) ◽  
pp. 142-146 ◽  
Author(s):  
Shiyan Ren ◽  
Yuxia Cao ◽  
Xiuwei Zhang ◽  
Shichen Jiao ◽  
Songyi Qian ◽  
...  
Keyword(s):  
Skin Test ◽  
Retrospective Review ◽  
Intravenous Antibiotics ◽  
Significant Difference ◽  
Negative Skin Test

Abstract Concomitant ingestion of alcohol and cephalosporin may cause a disulfiram-like reaction; however its fatal outcomes are not commonly known. We retrospectively reviewed 78 patients who had cephalosporin induced disulfiram-like reaction (CIDLR). The patients who had a negative skin test to cephalosporin prior to intravenous antibiotics were included, and those who were allergic to either alcohol or antibiotics were excluded. The average age of 78 patients was 37.8±12.2 (21–60) years. Of the 78 patients, 93.58% of the patients were males, 70.51% of the patients consumed alcohol after use of antibiotics, and 29.49% patients consumed alcohol initially, followed by intravenous antibiotics; however, no significant difference of morbidity was observed in these two groups. All patients were administered antibiotics intravenously. Five of 78 patients (6.41%) developed severe CIDLR too urgently to be rescued successfully. In conclusion, it is important for clinicians to educate patients that no alcohol should be used if one is taking cephalosporin. Also, clinicians should keep in mind that cephalosporin should not be prescribed for any alcoholics.

scholarly journals STUDIES ON TUBERCULIN FEVER

1959 ◽  
Vol 109 (4) ◽  
pp. 339-359 ◽  
Author(s):  
Charles H. Hall ◽  
Elisha Atkins
Keyword(s):  
Skin Test ◽  
Intravenous Administration ◽  
Causal Relation ◽  
Specific Property ◽  
Endogenous Pyrogen ◽  
Bacterial Endotoxins ◽  
Biologic Effects ◽  
Negative Skin Test

Evidence has been presented that the fever elicited by intravenous administration of old tuberculin (O.T.) in BCG-infected rabbits is a specific property of this hypersensitivity system and is probably not due to contamination of tuberculin with bacterial endotoxins. Daily injections of O.T. in sensitized animals resulted in a rapid tolerance to its pyrogenic effect. Tuberculin tolerance can be differentiated from that occurring with endotoxins and was invariably associated with the development of a negative skin test. The mechanism of this tolerance would thus appear to be desensitization. A circulating pyrogen found during tuberculin fever was indistinguishable in its biologic effects from endogenous pyrogens obtained in several other types of experimental fever. This material produced fevers in normal recipients and therefore may be clearly differentiated from O.T. itself which was pyrogenic only to sensitized animals. Since the titer of serum pyrogen was directly proportional to the degree of fever induced by injection of O.T. in the donor animals, a causal relation is suggested. On the basis of these findings, it is postulated that tuberculin fever is due to a circulating endogenous pyrogen released by a specific action of O.T. on sensitized cells of the host.

Carboplatin Skin Testing: A Skin-Testing Protocol for Predicting Hypersensitivity to Carboplatin Chemotherapy

2001 ◽  
Vol 19 (12) ◽  
pp. 3126-3129 ◽  
Author(s):  
K. M. Zanotti ◽  
L. A. Rybicki ◽  
A. W. Kennedy ◽  
J. L. Belinson ◽  
K. D. Webster ◽  
...  
Keyword(s):  
Skin Test ◽  
Skin Testing ◽  
Intradermal Injection ◽  
Positive Skin Test ◽  
Control Group ◽  
Test Protocol ◽  
Positive Skin ◽  
High Incidence ◽  
Negative Skin Test ◽  
Historical Controls

PURPOSE: A high incidence of moderate to severe hypersensitivity reactions (HRs) is noted in patients who have been treated with multiple courses of carboplatin. Presently, there is no reliable way to predict which patients may be at risk for this potentially severe adverse reaction. We developed a skin-test protocol to identify patients at high risk for HR to carboplatin chemotherapy. PATIENTS AND METHODS: Patients undergoing more than seven courses of carboplatin received a 0.02-mL intradermal injection of an undiluted aliquot of their planned carboplatin infusion 1 hour before each course of the agent. A positive skin test was prospectively defined as that resulting in a wheel of at least 5 mm with a surrounding flare. We recently reported a 27% incidence of HRs in patients receiving more than seven courses of carboplatin. These patients served as historical controls for the current study. RESULTS: Forty-seven patients with recurrent ovarian or primary peritoneal carcinoma receiving carboplatin were skin tested. Thirteen of 47 patients (28%) manifested a positive skin test at a median of nine total courses of carboplatin (range, eight to 17 courses). This rate of skin-test positivity was not significantly different from the incidence of documented HR reported in a historical control group (P = .89), suggesting comparable populations. A negative skin test accurately predicted the absence of HR in 166 of 168 courses of chemotherapy. Only two of 47 patients (4%) experienced a HR after a negative skin test. Thus, administering carboplatin only to patients with a negative skin test may result in a significant reduction in HRs relative to historical controls (P = .002). CONCLUSION: An easily performed skin test appears to predict patients in whom carboplatin may be safely administered. Treatment modifications based on the results of skin testing may reduce the incidence of HRs in patients receiving repeated courses of carboplatin.

Clinical Value Of a Negative Skin Test To Contrast Radio Media (CR) In Further Exposures

2014 ◽  
Vol 133 (2) ◽  
pp. AB269
Author(s):  
Luiz C.G. Arcanjo ◽  
Tania M.T. Gonçalves ◽  
Flavia C. Loyola ◽  
Matheus Ribeiro ◽  
Alfredo Alves Neto ◽  
...  
Keyword(s):  
Skin Test ◽  
Clinical Value ◽  
Negative Skin Test

scholarly journals Assessment of immediate and non-immediate hypersensitivity contrast reactions by skin tests and provocation tests: A review

2021 ◽  
Vol 35 ◽  
pp. 205873842110150
Author(s):  
Rakesh D Bansie ◽  
A Faiz Karim ◽  
Maurits S van Maaren ◽  
Maud AW Hermans ◽  
Paul LA van Daele ◽  
...  
Keyword(s):  
Contrast Media ◽  
Skin Test ◽  
Positive Skin Test ◽  
Skin Tests ◽  
Hypersensitivity Reactions ◽  
Immediate Hypersensitivity ◽  
Positive Skin ◽  
Provocation Tests ◽  
Iodinated Contrast ◽  
Negative Skin Test

Introduction: Allergic and nonallergic hypersensitivity reactions to iodinated contrast media (ICM) and gadolinium-based contrast media are classified as immediate or non-immediate hypersensitivity reactions (IHR and NIHR), respectively. Skin tests and provocation tests are recommended for the evaluation of hypersensitivity reactions to contrast agents; however provocations are not common in clinical practice. Methods: A MEDLINE search was conducted to investigate studies comprising both skin tests and provocation tests that evaluated hypersensitivity reactions to ICM. Results: Nineteen studies were identified that reported on skin tests, followed by provocations. In the case of IHR to ICM, 65/69 (94%) patients with a positive skin test for the culprit media tolerated a challenge with a skin-test-negative alternative ICM. In IHR to ICM with a negative skin test for the culprit media, provocations were positive in 3.2%–9.1% patients. In the case of a NIHR to ICM with a positive skin test, provocation with a skin-test-negative agent was tolerated in 75/105 (71%) of cases. In NIHR with a negative skin test for the culprit agent, re-exposure to the culprit or an alternative was positive in 0%–34.6% patients. Provocations with the same ICM in skin test positive patients with IHR or NIHR were positive for a majority of the patients, although such provocation tests were rarely performed. Data on hypersensitivity reactions, skin tests and provocations with gadolinium-based contrast media were limited; however, they exhibited a pattern similar to that observed in ICM. Conclusion: In both ICM and gadolinium-based contrast media, the risk of an immediate repeat reaction is low when skin tests are negative. In contrast, a provocation with a skin-test-positive contrast medium showed a high risk of an immediate repeat hypersensitivity reaction. Therefore, a thorough medical history is necessary, followed by skin tests. A provocation is recommended, for diagnostic work-up, when the diagnosis is uncertain.

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