XRCC3 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Xrcc3 Gene

scholarly journals A Recombination Repair Gene of Schizosaccharomyces pombe, rhp57, Is a Functional Homolog of the Saccharomyces cerevisiae RAD57 Gene and Is Phylogenetically Related to the Human XRCC3 Gene

Genetics ◽  
2000 ◽  
Vol 154 (4) ◽  
pp. 1451-1461 ◽  
Author(s):  
Yasuhiro Tsutsui ◽  
Takashi Morishita ◽  
Hiroshi Iwasaki ◽  
Hiroyuki Toh ◽  
Hideo Shinagawa
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Schizosaccharomyces Pombe ◽  
Genomic Library ◽  
Synthetic Lethality ◽  
Multicopy Plasmid ◽  
Repair Gene ◽  
Recombination Repair ◽  
Xrcc3 Gene ◽  
Γ Rays ◽  
Lower Temperature

Abstract To identify Schizosaccharomyces pombe genes involved in recombination repair, we identified seven mutants that were hypersensitive to both methyl methanesulfonate (MMS) and γ-rays and that contained mutations that caused synthetic lethality when combined with a rad2 mutation. One of the mutants was used to clone the corresponding gene from a genomic library by complementation of the MMS-sensitive phenotype. The gene obtained encodes a protein of 354 amino acids whose sequence is 32% identical to that of the Rad57 protein of Saccharomyces cerevisiae. An rhp57 (RAD57 homolog of S. pombe) deletion strain was more sensitive to MMS, UV, and γ-rays than the wild-type strain and showed a reduction in the frequency of mitotic homologous recombination. The MMS sensitivity was more severe at lower temperature and was suppressed by the presence of a multicopy plasmid bearing the rhp51 gene. An rhp51 rhp57 double mutant was as sensitive to UV and γ-rays as an rhp51 single mutant, indicating that rhp51 function is epistatic to that of rhp57. These characteristics of the rhp57 mutants are very similar to those of S. cerevisiae rad57 mutants. Phylogenetic analysis suggests that Rhp57 and Rad57 are evolutionarily closest to human Xrcc3 of the RecA/Rad51 family of proteins.

The Thr241Met polymorphism in the XRCC3 gene is associated with increased risk of cancer in Chinese mainland populations

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1371-1376 ◽  
Author(s):  
Liang Du ◽  
Tianyuan Xiong ◽  
Qing He ◽  
Yayi Wang ◽  
Jiani Shen ◽  
...  
Keyword(s):  
Chinese Mainland ◽  
Increased Risk ◽  
Xrcc3 Gene ◽  
Risk Of Cancer

Association of Thr241Met polymorphisms in XRCC3 gene and risk of differentiated thyroid carcinoma in Iran

2011 ◽  
Vol 44 (13) ◽  
pp. S198-S199
Author(s):  
Tanhaei Shokofeh ◽  
Fayaz Shima ◽  
Ebrahimi-Rad Mina ◽  
Bidoki Seyed Kazem ◽  
Fard-Esfahani Pezhman
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Xrcc3 Gene

scholarly journals Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma

2014 ◽  
Vol 2 (4) ◽  
pp. 553-558 ◽  
Author(s):  
ISABELLA WAI YIN CHEUK ◽  
SHEA PING YIP ◽  
DORA LAI WAN KWONG ◽  
VINCENT WING CHEUNG WU
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Xrcc3 Gene ◽  
Radiation Induced

scholarly journals The Relationship between XRCC1 and XRCC3 Gene Polymorphisms and Lung Cancer Risk in Northeastern Chinese

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56213 ◽  
Author(s):  
Shujie Guo ◽  
Xiaobo Li ◽  
Min Gao ◽  
Yuqiong Li ◽  
Bei Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Lung Cancer Risk ◽  
Xrcc3 Gene ◽  
The Relationship

XPA and XRCC3 gene polymorphisms and survival in esophageal cancer patients receiving neoadjuvant radiochemotherapy with cisplatin (CDDP), docetaxel (DTX), and 5-fluorouracil (FU)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e14571-e14571 ◽  
Author(s):  
M. Gusella ◽  
G. De Manzoni ◽  
R. Marinelli ◽  
S. Bruscagin ◽  
A. Bononi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Locally Advanced ◽  
Pathological Response ◽  
Rank Test ◽  
Neoadjuvant Radiochemotherapy ◽  
Risk Of Death ◽  
Increased Risk ◽  
Xrcc3 Gene

e14571 Background: The aim of the study was to evaluate if genetic polymorphism of DNA repair genes may predict pathological response and survival in patients affected by locally advanced esophageal cancer, treated with a neoadjuvant schedule including weekly DTX (35 mg/mq) and CDDP (25mg/mq), protracted venous infusion of FU (150 mg/mq/die) and concomitant radiotherapy for 8 weeks followed by surgery. Methods: Fifty-seven patients were enrolled, aged 60±7 years old. Median follow-up was 27 months. Genomic DNA was extracted from peripheral blood lymphocytes and XPA, XPD, XRCC1, ERCC1 and XRCC3 were genotyped through RFLP analysis. Associations between gene polymorphisms and pathological response and survival were analysed through Chi square test and Log rank test respectively. Results: Thirty-two patients presented complete remission (pCR) and 10 patients microfocal residual disease (pMRD); the remaining 15 patients were considered stable or non-responders (pS-NR). The event free(EFS) and overall (OS) median survival times have not yet reached; significantly better 3-year survival rates were observed after pCR than in case of pMRD and pS-NR (EFS: 87% vs 42.8%, p=0.0004; OS: 86% vs 56%, p=0.02, respectively). No association was found between pathological response or survival with XRCC1, ERCC1 and XPD polymorphisms. On the contrary, the XPA 23AA genotype showed an increased risk of recurrence (HR=3.5; 95% CI 1.3 to 43.7, p=0.02) and death (HR=4.4, 95% CI 1.9 to 78.2, p=0.009); there was a trend for reduced risk of negative pathological response with decreasing number of allele 23A : MRD and S-NR were found in 71%, 45% and 35% cases for AA, AG and GG genotypes, respectively. The XRCC3 241MetMet variant was significantly associated with increased risk of death (HR= 6.0, 95% CI 3.0 to 40.0, p=0.008); a trend toward a higher recurrence (p=0.07) and worse response (60% vs 43%) was found. Conclusions: XPA and XRCC3 gene defective variants were significantly associated with worse outcome and could predict OS in esophageal cancer patients treated with a neo-adjuvant intensive radio-chemotherapy protocol. Founded by CARIPARO, Italy No significant financial relationships to disclose.

Association of C722T polymorphism in XRCC3 gene with larynx cancer: a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5427-5430 ◽  
Author(s):  
Dong Li ◽  
Hui-Hua You ◽  
Yuan-Jing Jia ◽  
Jian-Dong Guo ◽  
Huan-LE Du
Keyword(s):  
Meta Analysis ◽  
Larynx Cancer ◽  
Xrcc3 Gene

Polymorphism of the XRCC3 gene and risk of gastric cancer in a Kashmiri population

2015 ◽  
Vol 24 (3) ◽  
pp. 167-175 ◽  
Author(s):  
Haamid Bashir ◽  
Sabhiya Majid ◽  
Rabia Hamid ◽  
Rabia Farooq ◽  
Hilal A. Wani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Xrcc3 Gene ◽  
Kashmiri Population

scholarly journals Increased carotid media thickness in cath lab workers exposed to chronic ionizing radiation and its interaction with DNA repair XRCC3 gene

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P3922-P3922
Author(s):  
A. Borghini ◽  
L. Gargani ◽  
A. Mercuri ◽  
F. Faita ◽  
S. Turchi ◽  
...  
Keyword(s):  
Dna Repair ◽  
Ionizing Radiation ◽  
Media Thickness ◽  
Xrcc3 Gene

scholarly journals Single nucleotide polymorphism rs1799794 in XRCC3 gene on breast cancer patients

2021 ◽  
Vol 62 (2) ◽  
pp. 5-9
Author(s):  
Thi Thu Thao Nguyen ◽  
◽  
Thu Thuy Nguyen ◽  
Vu Viet Ha Vuong ◽  
Huy Thinh Tran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Disease Onset ◽  
Strand Break ◽  
Control Group ◽  
Case Group ◽  
Protective Effects ◽  
Nucleotide Polymorphisms ◽  
Breast Cancer Patients ◽  
Single Nucleotide ◽  
Xrcc3 Gene

The single nucleotide polymorphisms of the XRCC3 gene including rs1799794 affect the DNA double-strand break/repair. Therefore, it plays a critical part in the initiation of carcinogenesis. This study aimed to investigate the distribution of rs1799794 and the association between rs1799794 and breast cancer risk. The study was performed in 208 Vietnamese females suffering from breast cancer and 208 age-matched normal healthy controls. DNA was extracted from whole blood whilst genotyping was conducted using PCR-RFLP. The results show that the frequency of the A and G allele in the case group are 0.575 and 0.425, in the control group are 0.548 and 0.452. The frequency of AA, AG, GG genotype in the case group are 34.6, 45.7, and 19.7%; in the control group are 33.2, 43.3, and 23.5%. AG genotype of rs1799794 associated with disease onset early of breast cancer, increasing the risk of breast cancer among those who were 45 years old and younger. The GG genotype has protective effects and reduces the risk of breast cancer in the age group ≤45 years.

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