scholarly journals Moderate Hepatic Insufficiency

2020 ◽  
Author(s):  
Keyword(s):  
Hepatic Insufficiency

The Clinical and Biochemical Features of Hepatic Insufficiency

1953 ◽  
Vol 25 (4) ◽  
pp. 471-486 ◽  
Author(s):  
Hugh R. Butt ◽  
Donald S. Amatuzio ◽  
Jesse L. Bollman ◽  
George J. Gabuzda ◽  
Button Giges ◽  
...  
Keyword(s):  
Hepatic Insufficiency ◽  
Biochemical Features

STEROIDSTOFFWECHSEL BEI BRUSTKREBS. III.

1959 ◽  
Vol XXXII (I) ◽  
pp. 23-32 ◽  
Author(s):  
Kurt Schubert ◽  
Hans Schröder
Keyword(s):  
Advanced Cancer ◽  
Liver Damage ◽  
Adsorption Chromatography ◽  
Hepatic Insufficiency ◽  
Loading Test ◽  
Patients With Cancer ◽  
Urinary Steroids ◽  
Normal Women

ABSTRACT A testosterone test using two different dosages was carried out simultaneously in 7 women suffering from metastasizing carcinoma of the mamma and in 3 normal women. In each case the urinary steroids were estimated before the beginning of the test and after administration of 50 mg and 100 mg of testosterone respectively; the interval between the single estimations being one week. The use of fractionated hydrolysis enabled a mild fission of the conjugates and the classification of the products into free steroids, glucuronosides, sulfates and unknown conjugates. The 17-ketosteroids and the testosterone were estimated by means of Girard's separation and adsorption chromatography. During the loading test with testosterone different behaviours became evident, which had not been realized before. The behaviour of the 17-ketosteroids rendered possible the differentiation of normal women from patients with cancer of the breast yet without hepatic insufficiency, and furthermore of these latter ones from those with a liver damage in addition to the cancer of the breast. The glucuronosides of the 17-ketosteroids are only depressed, when there exists a pronounced damage of the liver; the loading test making possible an extension of the range of recognizable damages. Furthermore, the behaviour of dehydroepiandrosterone (II/III), of androsterone (IV), and of aetiocholanolone (V) lends itself to this differentiation. In advanced cancer of the breast the values of II/III are invariably low, whilst IV and V often increase temporarily. The relation of IV to V may be altered in a different way. The excretion of not transformed testosterone is less in patients than in normal women and especially low in patients with liver damage.

HAEMOCLASIC CRISIS AS A TEST OF HEPATIC INSUFFICIENCY

BMJ ◽  
1923 ◽  
Vol 1 (3248) ◽  
pp. 574-574
Author(s):  
R. Chalmers
Keyword(s):  
Hepatic Insufficiency

Hepatic insufficiency in spawning Pacific salmon

1969 ◽  
Vol 4 (1) ◽  
pp. 1-3 ◽  
Author(s):  
E. G. Trams
Keyword(s):  
Pacific Salmon ◽  
Hepatic Insufficiency

Renal and electrolyte abnormalities in patients with hepatic insufficiency

1996 ◽  
Vol 2 (6) ◽  
pp. 413-417
Author(s):  
César Pérez Calvo ◽  
Fernando Suárez Sipmann ◽  
Carlos Caramelo
Keyword(s):  
Hepatic Insufficiency ◽  
Electrolyte Abnormalities

scholarly journals PALLIATIVE RESECTIONS OF A LIVER USING CRYODESTRUCTION FOR THE PATIENTS WHO HAVE BEEN REPEATEDLY OPERATED FOR ALVEOCOCCOSIS

2014 ◽  
Vol 13 (3) ◽  
pp. 25-31
Author(s):  
B. I. Alperovich ◽  
I. S. Zaytsev
Keyword(s):  
Surgical Treatment ◽  
Liver Resection ◽  
Compensatory Hypertrophy ◽  
Palliative Resection ◽  
Hepatic Insufficiency ◽  
Hepatoduodenal Ligament ◽  
Safe Method ◽  
Tissue Sections ◽  
Results Of Treatment ◽  
Vascular Structures

The purpose of work was the assessment of influence of a palliative resection of a liver with application of cryodestruction and without cryodestruction application on the remote results of treatment of the patients who have been repeatedly operated for alveococcosis.The analysis of surgical treatment of 14 patients operated repeatedly for alveococcosis of a liver is carried out. Patients were operated in the complicated stage of a disease in the presence of germination of a parasite in caval and/or portal gate of organ. Primary interventions were various – a diagnostic laparotomy, a cytoreduction and a marsupialization of a parasite, a liver resection. All patient at repetition intervention executed palliative resections of a liver. Resections were carried out by a clinic technique with imposing the ginglymoid of ligatures on remaining tissue of a liver at distance of 2–3 cm from the deleted parasitic knot taking into account a segmentary structure of organ. At all patients on "dangerous zones" (a zones of gate of a liver, a hepatoduodenal ligament) plates of parasitic fabric of various sizes from 1  2 cm to 2  4 cm were left. At 10 patients they were exposed to cryodestruction. The exposition in one point made from 1 to 2 minutes at a temperature –196 С. Postoperatively, patients received a dose of 10 mg/kg albendazole.Development of hepatic insufficiency after palliative resections of a liver is noted in one case. Lethal outcomes weren't.All patients for convenience of the analysis were divided into two groups: group of patients without application of cryotechnologies (n = 4) and group of the patients operated with application of cryodestruction (n = 10). Efficiency of palliative resections estimated on a median of survival of patients. Calculation of survival carried out Kaplan–Meier's method. The survival median in groups made 12 and 17 years respectively.When comparing survival of patients by Gehan's test with Yates's correction distinction of survival in two selections are statistically significant (z = 2,94; p < 0,005).Among patients repeatedly operated for alveococcosis when involving in parasitic process of gate of a liver, lack of possibility of prosthetics of vascular structures and developments of a compensatory hypertrophy of not struck departments of body the palliative resection allows to achieve survival of 50% of patients more than 16,8 years.Cryodestruction is the effective and safe method, allowing to increase survival of patients after a p alliative resection of a liver, through the destruction left in the area of the liver gate parasitic tissue sections.

scholarly journals Single-Dose Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor, in Subjects with Normal or Impaired Hepatic Function

2000 ◽  
Vol 44 (4) ◽  
pp. 821-826 ◽  
Author(s):  
Laurence Veronese ◽  
Jacques Rautaureau ◽  
Brian M. Sadler ◽  
Catherine Gillotin ◽  
Jean-Pierre Petite ◽  
...  
Keyword(s):  
Liver Disease ◽  
Healthy Volunteers ◽  
Total Bilirubin ◽  
Laboratory Data ◽  
Hepatic Insufficiency ◽  
Pharmacokinetic Parameters ◽  
Control Group ◽  
Bilirubin Concentration ◽  
Total Bilirubin Concentration ◽  
Severe Cirrhosis

ABSTRACT Amprenavir (141W94) is extensively metabolized by P450 cytochromes, specifically, CYP3A4. Because hepatic insufficiency reduces P450-mediated metabolism, the concentrations in plasma of drugs metabolized through this pathway are often increased in subjects with liver disease. Following administration of a single, oral dose of 600 mg of amprenavir, pharmacokinetic parameters were determined for 10 subjects with severe cirrhosis, 10 subjects with moderate cirrhosis, and 10 healthy volunteers. Model-independent methods for determining the area under the plasma concentration-time curve (AUC) from time zero to infinity (AUC0–∞) showed an increase in amprenavir AUC0–∞ of 2.5-fold in the group with moderate cirrhosis and 4.5-fold in the group with severe cirrhosis compared with that in the control group of healthy volunteers (P < 0.05). AUC0–∞ was linearly related to the severity of liver disease, as assessed by the Child-Pugh score. Of the laboratory data used to calculate the Child-Pugh score, only the mean total bilirubin concentration showed a significant relationship with AUC0–∞. The relationship between the total bilirubin concentration and the AUC0–∞ of amprenavir was well characterized by a simple E max model, suggesting that the total bilirubin concentration may be a useful parameter for predicting the amprenavir AUC in subjects with hepatic insufficiency. Finally, the sera of cirrhotic subjects showed significant decreases in the levels of α1-acid glycoprotein, the primary plasma binding protein for amprenavir. On the basis of the results of this study, for an exposure equivalent to a clinical dose of 1,200 mg twice daily in subjects without cirrhosis, subjects with Child-Pugh scores of 5 to 8 should receive a twice-daily 450-mg dose of amprenavir, and subjects with Child-Pugh scores of 9 to 15 should receive a twice-daily 300-mg dose of amprenavir.

Acute Renal Failure Complicating Viral Hepatitis in the Absence of Severe Hepatic Insufficiency

1985 ◽  
Vol 5 (5) ◽  
pp. 372-374 ◽  
Author(s):  
Jes&uacute;s Montoliu ◽  
Antonio Coca ◽  
Francisco Martinez-Orozco ◽  
Alejandro Darnell ◽  
Ram&oacute;n Sub&iacute;as ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Viral Hepatitis ◽  
Hepatic Insufficiency
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