scholarly journals Ependymal Differentiation

2020 ◽  
Author(s):  
Keyword(s):  
Ependymal Differentiation

Bilateral cerebellar epithelioid hemangioblastoma with possible ependymal differentiation in a patient with von Hippel-Lindau disease

2012 ◽  
Vol 32 (6) ◽  
pp. 662-667 ◽  
Author(s):  
Qing-xu Yang ◽  
Yang Li ◽  
Xiao-ying Tian ◽  
Bing Liao ◽  
Xiao-zhen Jiang ◽  
...  
Keyword(s):  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease ◽  
Ependymal Differentiation

scholarly journals EPEN-31. SINGLE-CELL RNAseq OF CHILDHOOD EPENDYMOMA REVEALS DISTINCT NEOPLASTIC CELL SUBPOPULATIONS THAT IMPACT ETIOLOGY, MOLECULAR CLASSIFICATION AND OUTCOME

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii314-iii314
Author(s):  
Andrew Donson ◽  
Austin Gillen ◽  
Riemondy Kent ◽  
Ahmed Gilani ◽  
Sujatha Venkataraman ◽  
...  
Keyword(s):  
Single Cell ◽  
Histological Analysis ◽  
Molecular Classification ◽  
Neoplastic Cell ◽  
Good Prognosis ◽  
Cellular Heterogeneity ◽  
Mesenchymal Phenotype ◽  
Ependymal Differentiation ◽  
Cell Subpopulations ◽  
Cell Niche

Abstract Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in the majority of children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development of effective therapy. We therefore used single-cell RNA sequencing to catalog cellular heterogeneity of 26 childhood EPN, predominantly from ST-RELA, PFA1 and PFA2 subgroups. ST-RELA and PFA subgroups clustered separately, with ST-RELA clustering largely according to individual sample-of-origin. PFA1 and PFA2 subgroup EPNs cells were intermixed and revealed 4 major subpopulations – 2 with characteristics of ependymal differentiation (transporter and ciliated phenotype subpopulations), an undifferentiated subpopulation and a mesenchymal phenotype. Pseudotime analysis showed the undifferentiated progenitor subpopulation either differentiating into ependymal differentiation subpopulations or transitioning into the mesenchymal subpopulation. Histological analysis revealed that undifferentiated and mesenchymal subpopulations cells colocalized to perinecrotic/perivascular zones, the putative ependymoma stem cell niche. Deconvolution of PFA bulk transcriptome data showed that undifferentiated and mesenchymal subpopulations were associated with a poor prognosis; whereas the ciliated ependymal cell-differentiated subpopulation was associated with a good prognosis. In conflict with current distinct classification paradigms, the ratio of mesenchymal and ciliated subpopulations determined bulk-tumor subgroups assignment to PFA1 and PFA2 respectively. This atlas of EPN cellular heterogeneity provides an important advance in our understanding of EPN biology, identifying high-risk associated subpopulations for therapeutic targeting.

Orbital Cyst with Ependymal Differentiation Associated with Microphthalmia

2020 ◽  
pp. 1-3
Author(s):  
Maria D. Garcia ◽  
Diva R. Salomao ◽  
Lilly H. Wagner
Keyword(s):  
Ependymal Differentiation

A multinodular ganglioglioma with ependymal differentiation

2011 ◽  
Vol 30 (07) ◽  
pp. 206-209 ◽  
Author(s):  
Y.-F. Wang ◽  
Y.-S. Piao ◽  
D.-H. Lu ◽  
J. Liu
Keyword(s):  
Ependymal Differentiation

Central neurocytoma expressing characteristics of ependymal differentiation: electron microscopic findings of two cases

2003 ◽  
Vol 36 (2) ◽  
pp. 98-105 ◽  
Author(s):  
Toshiro Shimura ◽  
Osamu Mori ◽  
Takayuki Kitamura ◽  
Shiro Kobayashi ◽  
Naoko Sanno ◽  
...  
Keyword(s):  
Central Neurocytoma ◽  
Electron Microscopic ◽  
Ependymal Differentiation ◽  
Microscopic Findings
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