scholarly journals Progesterone Antagonist

2020 ◽  
Author(s):  
Keyword(s):  
Progesterone Antagonist

Effect of progesterone antagonist mifepristone on plasma CRH in term human pregnancy

1998 ◽  
Vol 5 (1) ◽  
pp. 196A-196A
Author(s):  
J BYRNE ◽  
D WING ◽  
M FRASER ◽  
M FASSETT ◽  
A BOCKING ◽  
...  
Keyword(s):  
Human Pregnancy ◽  
Progesterone Antagonist

Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice

1995 ◽  
Vol 269 (1) ◽  
pp. R154-R159 ◽  
Author(s):  
E. Goujon ◽  
P. Parnet ◽  
A. Aubert ◽  
G. Goodall ◽  
R. Dantzer
Keyword(s):  
Interleukin 1 ◽  
Behavioral Effects ◽  
Protective Effects ◽  
Interleukin 1 Beta ◽  
Social Exploration ◽  
Inhibitory Feedback ◽  
Adrenal Response ◽  
Acute Injection ◽  
Progesterone Antagonist

The modulatory role of endogenous corticoids in the behavioral effects of lipopolysaccharide (LPS) and recombinant human interleukin-1 beta (IL-1 beta) was studied in mice. Adrenalectomy enhanced the depression of social exploration induced by subcutaneous injection of 200 ng of IL-1 beta or 2 micrograms of LPS. This effect was mimicked by an acute injection of the progesterone antagonist RU-38486 (0.25-1 mg). Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS. These results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.

Effects of the Progesterone Antagonist RU486 on Ovarian Activity in the Rat*

Endocrinology ◽  
1987 ◽  
Vol 121 (4) ◽  
pp. 1375-1382 ◽  
Author(s):  
P. VAN DER SCHOOT ◽  
G. H. BAKKER ◽  
J. G. M. KLIJN
Keyword(s):  
Ovarian Activity ◽  
Antagonist Ru486 ◽  
Progesterone Antagonist
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