Renal Corpuscle | ScienceGate

Renal morphology and glomerular capillarisation in young adult sheep born moderately preterm

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174420001208 ◽

2020 ◽

pp. 1-7

Author(s):

Megan R. Sutherland ◽

Waleed Malik ◽

Vivian B. Nguyen ◽

Vivian Tran ◽

Graeme R. Polglase ◽

...

Keyword(s):

Preterm Birth ◽

Surface Area ◽

Early Adulthood ◽

Capillary Length ◽

Renal Corpuscle ◽

Adult Sheep ◽

Glomerular Capillary ◽

Renal Morphology ◽

Increased Risk ◽

Moderately Preterm

Abstract Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term impact of preterm birth on renal morphology, in adult sheep. Singleton male sheep were delivered moderately preterm at 132 days (~0.9) of gestation (n = 6) or at term (147 days gestation; n = 6) and euthanised at 14.5 months of age (early adulthood). Stereological methods were used to determine mean renal corpuscle and glomerular volumes, and glomerular capillary length and surface area, in the outer, mid and inner regions of the renal cortex. Glomerulosclerosis and interstitial collagen levels were assessed histologically. By 14.5 months of age, there was no difference between the term and preterm sheep in body or kidney weight. Renal corpuscle volume was significantly larger in the preterm sheep than the term sheep, with the preterm sheep exhibiting enlarged Bowman’s spaces; however, there was no difference in glomerular volume between groups, with no impact of preterm birth on capillary length or surface area per glomerulus. There was also no difference in interstitial collagen levels or glomerulosclerosis index between groups. Findings suggest that moderate preterm birth does not adversely affect glomerular structure in early adulthood. The enlarged Bowman’s space in the renal corpuscles of the preterm sheep kidneys, however, is of concern and merits further research into its cause and functional consequences.

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Immunohistochemical determination of calbindin-d28k in the kidney of postnatal rats

Veterinární Medicína ◽

10.17221/5713-vetmed ◽

2012 ◽

Vol 49 (No. 9) ◽

pp. 334-338 ◽

Cited By ~ 3

Author(s):

S. Timurkaan ◽

B. G Tarakci

Keyword(s):

Proximal Tubule ◽

Intracellular Calcium ◽

Rat Kidney ◽

Renal Corpuscle ◽

Specific Localization ◽

Calbindin D28k ◽

Collecting Tubules ◽

Convoluted Tubules ◽

Postnatal Rats

The localization of calbindin-D28k was examined in rat kidney at different stages of development. Calbindin was found specifically in the distal convoluted tubules (DCT). In the 10 day old rat kidney many cells apparently belonging to the collecting tubules were positive. In the neonatal nephrons there was also localization of calbindin-D28k to the limb of Henle, suggesting a difference in the regulation of intracellular calcium during maturation. Proximal tubule, renal corpuscle and macula densa gave no specific localization of calbindin-D28k.

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Renal corpuscle of the sturgeon kidney: An ultrastructural, chemical dissection, and lectin-binding study

The Anatomical Record ◽

10.1002/ar.a.10068 ◽

2003 ◽

Vol 272A (2) ◽

pp. 563-573 ◽

Cited By ~ 17

Author(s):

Jos� L. Ojeda ◽

Jos� M. Icardo ◽

Alberto Domezain

Keyword(s):

Lectin Binding ◽

Binding Study ◽

Renal Corpuscle

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Renal Corpuscle Development in the Dog

Kidney & Blood Pressure Research ◽

10.1159/000172682 ◽

1978 ◽

Vol 1 (6) ◽

pp. 338-347

Author(s):

Vincent H. Gattone II ◽

Michael L. Johnson ◽

Dennis E. Morse

Keyword(s):

Renal Corpuscle

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Cytological Studies on the Renal Corpuscle and the Proximal Convolution of the Renal Tubulus in the Human Kidney

Archivum histologicum japonicum ◽

10.1679/aohc1950.8.195 ◽

1955 ◽

Vol 8 (2) ◽

pp. 195-215 ◽

Cited By ~ 2

Author(s):

Yoshiro SUNAGA

Keyword(s):

Human Kidney ◽

Renal Corpuscle ◽

Proximal Convolution

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On the Basement Membrane of the Nephron

Urologia Journal ◽

10.1177/039156036503200105 ◽

1965 ◽

Vol 32 (1) ◽

pp. 44-50

Author(s):

Antti Paalanen

Keyword(s):

Connective Tissue ◽

Basement Membrane ◽

Outer Membrane ◽

Renal Tubule ◽

Basement Membranes ◽

Functional Adaptation ◽

Renal Tubules ◽

Elastic Tissue ◽

Renal Corpuscle ◽

Bowman's Capsule

This study comprises some observations about the structure of the connective tissue of the basement membrane and interstitium in some normal, post-natal human kidneys. The basis of the basement membrane is mainly a reticular, homogeneous membrane that belongs uniformly to both Bowman's capsule and the wall of the renal tubule. Outside it in the capsule is a durable collagenic membrane whose development must be considered and evincement of functional adaptation under the pressure conditions of the cavity. In renal tubules there is no such well-defined outer membrane, but in them the basement membrane has in addition collagenic traits to some extent and is thus reticular-collagenic when examined as a whole. The renal tubules are surrounded by a dense, spiraling reticular network of fibres which attaches to the connective tissue of the interstitium where fibrocytes are scarce. The network extends all the way around the renal corpuscle. There is no elastic tissue at all in the basement membranes.

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