Bronchial Lymph Node

2020 ◽  
Author(s):  
Keyword(s):  
Lymph Node ◽  
Bronchial Lymph Node

scholarly journals In Vivo Expression of and Cell-Mediated Immune Responses to the Plasmid-Encoded Virulence-Associated Proteins of Rhodococcus equi in Foals

2007 ◽  
Vol 14 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Stephanie Jacks ◽  
Steeve Giguère ◽  
John F. Prescott
Keyword(s):  
Lymph Node ◽  
Rhodococcus Equi ◽  
Interleukin 4 ◽  
Significant Difference ◽  
In Vivo Expression ◽  
Associated Proteins ◽  
Ifn Γ ◽  
Bronchial Lymph Node

ABSTRACT Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in foals but does not induce disease in adult horses. Virulence of R. equi depends on the presence of a large plasmid, which encodes a family of seven virulence-associated proteins (VapA and VapC to VapH). Eradication of R. equi from the lungs depends on gamma interferon (IFN-γ) production by T lymphocytes. The objectives of the present study were to determine the relative in vivo expression of the vap genes of R. equi in the lungs of infected foals, to determine the recall response of bronchial lymph node (BLN) lymphocytes from foals and adult horses to each of the Vap proteins, and to compare the cytokine profiles of proliferating lymphocytes between foals and adult horses. vapA, vapD, and vapG were preferentially expressed in the lungs of infected foals, and expression of these genes in the lungs was significantly (P < 0.05) higher than that achieved during in vitro growth. VapA and VapC induced the strongest lymphoproliferative responses for foals and adult horses. There was no significant difference in recall lymphoproliferative responses or IFN-γ mRNA expression by bronchial lymph node lymphocytes between foals and adults. In contrast, interleukin 4 (IL-4) expression was significantly higher for adults than for foals for each of the Vap proteins. The ratio of IFN-γ to IL-4 was significantly higher for foals than for adult horses for most Vap proteins. Therefore, foals are immunocompetent and are capable of mounting lymphoproliferative responses of the same magnitude and cytokine phenotype as those of adult horses.

scholarly journals Induction of Tolerance to Innocuous Inhaled Antigen Relies on a CCR7-Dependent Dendritic Cell-Mediated Antigen Transport to the Bronchial Lymph Node

2006 ◽  
Vol 177 (10) ◽  
pp. 7346-7354 ◽  
Author(s):  
Gabriele Hintzen ◽  
Lars Ohl ◽  
Maria-Luisa del Rio ◽  
Jose-Ignacio Rodriguez-Barbosa ◽  
Oliver Pabst ◽  
...  
Keyword(s):  
Lymph Node ◽  
Dendritic Cell ◽  
Antigen Transport ◽  
Bronchial Lymph Node ◽  
Induction Of Tolerance

Gender differences in transcriptional regulation of IL-5 expression by bronchial lymph node cells in a mouse model of asthma

Respirology ◽  
2010 ◽  
Vol 15 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Kana WADA ◽  
Kaori OKUYAMA ◽  
Yuichi OHKAWARA ◽  
Motoaki TAKAYANAGI ◽  
Isao OHNO
Keyword(s):  
Gender Differences ◽  
Transcriptional Regulation ◽  
Lymph Node ◽  
Mouse Model ◽  
Lymph Node Cells ◽  
Bronchial Lymph Node

scholarly journals CD103− and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells

2007 ◽  
Vol 178 (11) ◽  
pp. 6861-6866 ◽  
Author(s):  
Maria-Luisa del Rio ◽  
Jose-Ignacio Rodriguez-Barbosa ◽  
Elisabeth Kremmer ◽  
Reinhold Förster
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Bronchial Lymph Node

scholarly journals Gammaherpesvirus Infections in Cattle in Europe

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2337
Author(s):  
Giuliana Rosato ◽  
Andres Ruiz Subira ◽  
Mohammed Al-Saadi ◽  
Eleni Michalopoulou ◽  
Ranieri Verin ◽  
...  
Keyword(s):  
United Kingdom ◽  
Lymph Node ◽  
Quantitative Pcr ◽  
High Frequency ◽  
Bovine Herpesvirus ◽  
Malignant Catarrhal Fever ◽  
Viral Loads ◽  
Herpesvirus 1 ◽  
Bronchial Lymph Node ◽  
Reservoir Hosts

The genus Macavirus, subfamily Gammaherpesvirinae, comprises ungulate viruses that infect domestic and wild ruminants and swine. They cause asymptomatic latent infections in reservoir hosts and malignant catarrhal fever in susceptible species. Lung, spleen, bronchial lymph node, and tongue were collected from 448 cattle (348 necropsied, 100 slaughtered) in Switzerland, United Kingdom, Finland, Belgium, and Germany to determine their infection with bovine herpesvirus-6 (BoHV-6) and gammaherpesviruses of other ruminants, i.e., ovine herpesvirus-1 and -2, caprine herpesvirus-2, and bison lymphotropic herpesvirus, using quantitative PCR. Only BoHV-6 was detected, with an overall frequency of 32%, ranging between 22% and 42% in the different countries. Infection was detected across all ages, from one day after birth, and was positively correlated with age. There was no evidence of an association with specific disease processes. In positive animals, BoHV-6 was detected in all organs with high frequency, consistently in the lungs or spleen. Viral loads varied substantially. In BoHV-6-positive gravid cows, organs of fetuses tested negative for infection, indicating that the virus is not vertically transmitted. Our results confirm previous data indicating that BoHV-6 is a commensal of domestic cattle not associated with disease processes and confirm that infections with other macaviruses are rare and sporadic.

scholarly journals Experimental challenge with bovine respiratory syncytial virus in dairy calves: bronchial lymph node transcriptome response

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Dayle Johnston ◽  
Bernadette Earley ◽  
Matthew S. McCabe ◽  
Ken Lemon ◽  
Catherine Duffy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Respiratory Syncytial Virus ◽  
Clinical Signs ◽  
Bovine Respiratory Syncytial Virus ◽  
Holstein Friesian ◽  
Differential Gene ◽  
Syncytial Virus ◽  
Bronchial Lymph Node ◽  
And Control

Abstract Bovine Respiratory Disease (BRD) is the leading cause of mortality in calves. The objective of this study was to examine the response of the host’s bronchial lymph node transcriptome to Bovine Respiratory Syncytial Virus (BRSV) in a controlled viral challenge. Holstein-Friesian calves were either inoculated with virus (103.5 TCID50/ml × 15 ml) (n = 12) or mock challenged with phosphate buffered saline (n = 6). Clinical signs were scored daily and blood was collected for haematology counts, until euthanasia at day 7 post-challenge. RNA was extracted and sequenced (75 bp paired-end) from bronchial lymph nodes. Sequence reads were aligned to the UMD3.1 bovine reference genome and differential gene expression analysis was performed using EdgeR. There was a clear separation between BRSV challenged and control calves based on gene expression changes, despite an observed mild clinical manifestation of the disease. Therefore, measuring host gene expression levels may be beneficial for the diagnosis of subclinical BRD. There were 934 differentially expressed genes (DEG) (p < 0.05, FDR <0.1, fold change >2) between the BRSV challenged and control calves. Over-represented gene ontology terms, pathways and molecular functions, among the DEG, were associated with immune responses. The top enriched pathways included interferon signaling, granzyme B signaling and pathogen pattern recognition receptors, which are responsible for the cytotoxic responses necessary to eliminate the virus.

scholarly journals μ-opioid Receptor-Mediated Alterations of Allergen-Induced Immune Responses of Bronchial Lymph Node Cells in a Murine Model of Stress Asthma

2012 ◽  
Vol 61 (2) ◽  
pp. 245-258 ◽  
Author(s):  
Kaori Okuyama ◽  
Soichiro Ide ◽  
Shinobu Sakurada ◽  
Kazumasu Sasaki ◽  
Ichiro Sora ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune Responses ◽  
Opioid Receptor ◽  
Murine Model ◽  
Lymph Node Cells ◽  
Μ Opioid Receptor ◽  
Bronchial Lymph Node
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