scholarly journals Mature Plasma Cell to Lymphocyte Ratio Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Plasma Cell ◽  
Ratio Measurement ◽  
Lymphocyte Ratio ◽  
Mature Plasma Cell

scholarly journals Phenotypic heterogeneity in aneuploid multiple myeloma indicates pre-B cell involvement

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 861-865
Author(s):  
J Epstein ◽  
B Barlogie ◽  
J Katzmann ◽  
R Alexanian
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Tumor Cells ◽  
Plasma Cell ◽  
Lymphoblastic Leukemia ◽  
Cell Markers ◽  
Aneuploid Tumor ◽  
Beta 2 Microglobulin ◽  
Normal Differentiation ◽  
Mature Plasma Cell

The expression of early and mature B cell markers, surface beta 2- microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the patients contained monoclonal clg and expressed the mature plasma cell antigen R1–3 as well as surface B2M; common acute lymphoblastic leukemia antigen (CALLA) was present in 55%, B2 in 17%, and B4 in 23% of samples studied. Coexpression of CALLA and clg in 46% of all patients identified a novel myeloma phenotype without known counterpart in the normal differentiation of B cells. CALLA and clg were independently expressed and gave rise to CALLA+/clg-, CALLA+/clg+, and CALLA-/clg+ cells. The association of CALLA and mature plasma cell markers may define discrete stages of neoplastic plasma cell differentiation.

scholarly journals Inhibition of DEPDC1A, a Bad Prognostic Marker in Multiple Myeloma, Delays Growth and Induces Mature Plasma Cell Markers in Malignant Plasma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62752 ◽  
Author(s):  
Alboukadel Kassambara ◽  
Matthieu Schoenhals ◽  
Jérôme Moreaux ◽  
Jean-Luc Veyrune ◽  
Thierry Rème ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Marker ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Cell Markers ◽  
Mature Plasma Cell
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