scholarly journals Review of: "B.P.F.C PURE GROWTH FACTOR, PDT AND LLLT FOR THE TREATMENT OF SEVERE MRONJ NON-RESPONSIVE TO PROLONGED ANTIBIOTIC THERAPY"

Qeios ◽  
2021 ◽  
Author(s):  
W.H WANG
Keyword(s):  
Growth Factor ◽  
Antibiotic Therapy ◽  
Prolonged Antibiotic Therapy

scholarly journals B.P.F.C PURE GROWTH FACTOR, PDT AND LLLT FOR THE TREATMENT OF SEVERE MRONJ NON-RESPONSIVE TO PROLONGED ANTIBIOTIC THERAPY

Qeios ◽  
2021 ◽  
Author(s):  
Raffaello Viganò ◽  
Martina Salvatorina Murgia ◽  
Germano Orrù ◽  
luca vigano ◽  
Cinzia Casu
Keyword(s):  
Growth Factor ◽  
Antibiotic Therapy ◽  
Prolonged Antibiotic Therapy

scholarly journals B.P.F.C PURE GROWTH FACTOR, PDT AND LLLT FOR THE TREATMENT OF SEVERE MRONJ NON-RESPONSIVE TO PROLONGED ANTIBIOTIC THERAPY

Qeios ◽  
2021 ◽  
Author(s):  
Raffaello Viganò ◽  
Martina Salvatorina Murgia ◽  
Germano Orrù ◽  
luca vigano ◽  
Cinzia Casu
Keyword(s):  
Growth Factor ◽  
Antibiotic Therapy ◽  
Prolonged Antibiotic Therapy

Persistent Multispecies Actinomyces Mastitis Treated With Repeated Aspiration and Long-Term Oral Antibiotics

2021 ◽  
pp. 000313482110257
Author(s):  
Colin Jenkins ◽  
Anand Ganapathy ◽  
Crystal Fancher ◽  
Kazuhide Matsushima
Keyword(s):  
Antibiotic Therapy ◽  
Rare Condition ◽  
Breast Abscess ◽  
Amoxicillin Clavulanic Acid ◽  
Recurrent Breast ◽  
Causative Bacterium ◽  
Repeated Aspiration ◽  
Prolonged Antibiotic Therapy

Actinomycosis is an infection characterized by abscess formation, draining sinuses, and tissue fibrosis. The causative bacterium is a Gram-positive facultative anaerobe from the genus Actinomyces. Infections classically affect the cervicofacial, thoracic, or pelvic region and often require prolonged antibiotic therapy. Actinomycosis of the breast is a rare condition that may present as a recurrent breast abscess. We present a 33-year-old female with a recurrent breast abscess which grew A. radingae and A. israeli on aspirated fluid cultures. Treatment with surgical aspiration and a 6-week course of oral amoxicillin/clavulanic acid 875 mg twice daily resulted in clinical improvement. Our case demonstrates how recurrent breast abscesses caused by Actinomyces can be difficult to manage. Long-term antibiotic therapy with surgical aspiration and regular follow-up offer the best chance of clinical resolution.

scholarly journals Antibiotic-Induced Neutropenia During Treatment of Hematogenous Osteoarticular Infections in Otherwise Healthy Children

2019 ◽  
Vol 24 (5) ◽  
pp. 431-437
Author(s):  
Krystian Solis ◽  
Walter Dehority
Keyword(s):  
Antibiotic Therapy ◽  
Clinical Information ◽  
Healthy Children ◽  
Osteoarticular Infections ◽  
Younger Age ◽  
Increased Risk ◽  
Multivariable Regression Model ◽  
Multivariable Regression ◽  
Time To Onset ◽  
Prolonged Antibiotic Therapy

OBJECTIVES We studied the frequency and characteristics of antibiotic-induced neutropenia in otherwise healthy children receiving antibiotic therapy for hematogenous osteoarticular infections (OAIs). METHODS We retrospectively enrolled otherwise healthy children between 1 month and 18 years of age discharged with an OAI from our institution over an 11-year period. An absolute neutrophil count (ANC) ≤1500 cells/μL was defined as neutropenia. We recorded demographic and clinical information, as well as the value and timing of each ANC in relation to changes in antibiotic therapy. A multivariable regression model assessed the contributions of various risk factors. RESULTS A total of 186 children were enrolled (mean age, 7.6 years; 67.2% boys). β-Lactams represented 61.2% of all prescriptions. During treatment, 61 subjects (32.8%) developed neutropenia (median time to onset, 24 days). An ANC < 500 cells/μL occurred in 7 subjects (3.8%). Neutropenic subjects (mean age, 6.0 years) were significantly younger than those without neutropenia (mean age, 8.5 years) (OR = 0.86; 95% CI: 0.79–0.93; p < 0.001) and received significantly longer courses of total (89.3 vs. 55.8 days) and parenteral (24.6 vs. 19.9 days) antibiotic therapy (OR = 1.01; 95% CI: 1.01–1.02; p = 0.004 and OR = 1.02; 95% CI: 1.01–1.04; p = 0.041, respectively). Recurrent neutropenia occurred in 23.0% of all neutropenic subjects and was significantly more common in those with a longer mean duration of parenteral therapy (OR = 1.05; 95% CI: 1.02–1.09; p = 0.004.). No complications from neutropenia occurred. CONCLUSIONS Neutropenia was common in our cohort of children receiving prolonged antibiotic therapy for OAIs. Younger age and longer courses of therapy were associated with an increased risk of neutropenia.

scholarly journals Association of intraperitoneal ceftriaxone, intravenous gentamicin and oral metronidazole in the treatment of an abdominal abscess and peritonitis in a horse

2020 ◽  
Vol 57 (2) ◽  
pp. e166204
Author(s):  
Juliana De Moura Alonso ◽  
Alice Ribeiro Ávila ◽  
Emanuel Vitor Pereira Apolonio ◽  
Bruna dos Santos ◽  
Ana Liz Garcia Alves ◽  
...  
Keyword(s):  
Physical Examination ◽  
Antibiotic Therapy ◽  
Plasma Fibrinogen ◽  
Abdominal Abscess ◽  
Success Rates ◽  
Broad Spectrum Antibiotic ◽  
Abdominal Abscesses ◽  
History Of ◽  
Prolonged Antibiotic Therapy ◽  
Oral Metronidazole

Medical management of abdominal abscesses in horses requires prolonged antibiotic therapy and presents varied success rates. A 6-year-old male horse with a history of colic and multiple abdominal punctures to relieve gas was attended. At admission, tachycardia, tachypnea, hyperthermia, mucosal congestion, dehydration, and rigid gait were observed. The association of physical examination, laboratory and ultrasonographic findings allowed the diagnoses of peritonitis and abdominal abscess. Supporting treatment plus broad spectrum antibiotic therapy was performed: daily intraperitoneal ceftriaxone (25 mg/kg, 7 days); daily intravenous gentamicin (6.6 mg/kg, 7 days); per os metronidazole three times a day (15 mg/kg 12 days), followed by the same dose twice a day (15 mg/kg 33 days), totaling 45 days of treatment. Plasma fibrinogen and ultrasonographic examination were the most effective tools to evaluate abscess evolution. There was normalization of the physical examination 24 h after beginning the treatment, consecutive regression of the nucleated cell count in the peritoneal fluid, and regression of plasma fibrinogen and size of the abscess. On the 10th treatment day, the animal was discharged from the hospital, maintaining oral therapy with metronidazole every 12 h (15 mg / kg). When the animal returned on the 30th day, an abscess size regression was observed. However, there was no resolution, and therapy with metronidazole was maintained. On the 45th day of treatment, a new hospital evaluation was performed, where the abscess resolved, and metronidazole was suspended. It is highlighted that the therapeutic association used in the treatment of abdominal infection and abscess resulted in a rapid clinical response

Short-course antibiotic treatment of bone and joint infections in children: a retrospective study at Montpellier University Hospital from 2009 to 2013

2019 ◽  
Vol 74 (12) ◽  
pp. 3579-3587 ◽  
Author(s):  
A Filleron ◽  
M E Laurens ◽  
G Marin ◽  
H Marchandin ◽  
O Prodhomme ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Antibiotic Therapy ◽  
Septic Arthritis ◽  
Treatment Duration ◽  
University Hospital ◽  
Short Term ◽  
Joint Infections ◽  
Intravenous Treatment ◽  
Short Course ◽  
Prolonged Antibiotic Therapy

Abstract Background Acute haematogenous bone and joint infections (AHBJI) represent a diagnostic and therapeutic emergency in children, with significant potential sequelae in the case of delayed treatment. Although historically the recommendations for treatment have been based on surgery and prolonged antibiotic therapy, recent studies have demonstrated that short-course antibiotic therapy is also effective. Objectives We evaluated a short-term antibiotic protocol for both osteomyelitis and septic arthritis in a 6 year retrospective study at the University Hospital of Montpellier. Methods This protocol was based on an initial intravenous treatment with a re-evaluation after 48 h and an early switch to oral therapy in the case of a favourable clinical course for a minimum total duration of 15 days. Antibiotics were selected based on local microbiological epidemiology and systematically adapted to bacteriological results. Results One hundred and seventy-six cases of AHBJI were included, comprising 56 patients with osteomyelitis, 95 with septic arthritis and 25 who had both of these. The aetiological agent was identified in 42% of the cases, with the main pathogens being Staphylococcus aureus (39%) and Kingella kingae (27%). The mean intravenous treatment duration was 4 days, while the total treatment duration was 15 days. There were no treatment failures, mild sequelae occurred in 1% of the cases and the secondary surgical revision rate was 7%. Conclusions The results of this study are comparable to those reported for evaluations of prolonged antibiotic therapy protocols, thus indicating that a common short-term antimicrobial therapy for the management of both osteomyelitis and septic arthritis (minimum of 15 days) is a viable option for treating AHBJI in children. Further prospective studies to confirm these findings are hence warranted.

Bacterial aneurysms of the intracavernous carotid artery

1984 ◽  
Vol 60 (6) ◽  
pp. 1236-1242 ◽  
Author(s):  
Damodar Rout ◽  
Ajay Sharma ◽  
Pochiraju K. Mohan ◽  
Vedula R. K. Rao
Keyword(s):  
Carotid Artery ◽  
Antibiotic Therapy ◽  
Cavernous Sinus ◽  
Internal Carotid ◽  
Giant Aneurysm ◽  
The Other ◽  
Content Type ◽  
Results Of Treatment ◽  
Intracavernous Carotid Artery ◽  
Prolonged Antibiotic Therapy

✓ Six cases of bacterial intracavernous carotid artery aneurysms of extravascular origin secondary to cavernous sinus thrombophlebitis are reported along with a review of 12 similar cases collected from the literature. Of the authors' six cases, there were three children and three adults. Meningitis was found in five patients. All patients received prolonged antibiotic therapy. Spontaneous resolution of the aneurysm occurred in one patient, thrombosis of the internal carotid artery in another, and progressive enlargement of the aneurysm was seen on sequential angiography in the other two. Evidence of associated arteritis was present in all of the patients. Carotid ligation for persistent ophthalmoplegia was carried out in two patients, of whom one had a giant aneurysm and the other progressive aneurysm enlargement. The results of treatment were good in all cases. The authors believe that carotid arteriography is obligatory in cases of cavernous sinus thrombophlebitis in which ophthalmoplegia persists despite adequate antibiotic therapy.

Sign in / Sign up

Export Citation Format

Share Document