Loss of Chromosome 10q

2020 ◽  
Author(s):  
Keyword(s):  
Chromosome 10Q

scholarly journals Cholesterol 25-Hydroxylase on Chromosome 10q Is a Susceptibility Gene for Sporadic Alzheimer’s Disease

2005 ◽  
Vol 2 (5) ◽  
pp. 233-241 ◽  
Author(s):  
Andreas Papassotiropoulos ◽  
Jean-Charles Lambert ◽  
Fabienne Wavrant-De Vrièze ◽  
M. Axel Wollmer ◽  
Heinz von der Kammer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Susceptibility Gene ◽  
Sporadic Alzheimer’S Disease ◽  
Chromosome 10Q

Early renal insufficiency in a neonate with de novo partial trisomy of chromosome 10q

2003 ◽  
Vol 123A (2) ◽  
pp. 164-168 ◽  
Author(s):  
Nata?a Mar?un Varda ◽  
N. Kokalj Voka? ◽  
Z. Kani? ◽  
K. Bra?i? ◽  
A. Erjavec ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
De Novo ◽  
Partial Trisomy ◽  
Chromosome 10Q

scholarly journals Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

1999 ◽  
Vol 64 (4) ◽  
pp. 1127-1140 ◽  
Author(s):  
Ravindranath Duggirala ◽  
John Blangero ◽  
Laura Almasy ◽  
Thomas D. Dyer ◽  
Kenneth L. Williams ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mexican Americans ◽  
Age At Onset ◽  
Chromosome 10Q ◽  
Genetic Location

scholarly journals Evidence for the founder effect of RET533 as the common Greek and Brazilian ancestor spreading multiple endocrine neoplasia 2A

2017 ◽  
Vol 176 (5) ◽  
pp. 515-519 ◽  
Author(s):  
Lucas L Cunha ◽  
Susan C Lindsey ◽  
Maria Inez C França ◽  
Leda Sarika ◽  
Alexandra Papathoma ◽  
...  
Keyword(s):  
Medullary Thyroid Cancer ◽  
Dna Analysis ◽  
Common Ancestor ◽  
Inherited Disease ◽  
Rare Mutation ◽  
Chromosome 10Q ◽  
Ancestral Origin ◽  
Multiple Endocrine Neoplasia 2A ◽  
The Common ◽  
Brazilian Cohort

Objectives About one-quarter of patients with medullary thyroid cancer (MTC) have inherited disease due to mutations in the RET gene. A rare mutation in exon 8 (G533C) of RET, previously described in a large Brazilian family with MEN2A, also appeared to be clustering in Greece, whereas it was rarely reported in other ethnic groups. The aim of this study was to identify a possible common ancestry between these carriers. Patients and methods Twelve RET G533C mutation carriers, four randomly selected from the Brazilian cohort and eight from apparently unrelated Greek families, were studied for a possible common ancestral origin. RET flanking microsatellite markers at chromosome 10q (D10S197, D10S196, D10S1652 and D10S537) were used. Results Genomic DNA analysis using these markers showed that many of these apparently unrelated individuals shared a common haplotype indicating a common ancestral origin. Conclusion Our data suggest that Brazilian and Greek patients with MTC carrying the G533C mutation in exon 8 of RET gene originate from a common ancestor. Due to historical reasons, we speculate that the more plausible explanation for the origin of this mutation is in Greece.

Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome

Genomics ◽  
1995 ◽  
Vol 26 (2) ◽  
pp. 207-209 ◽  
Author(s):  
Joel Gelernter ◽  
Peter A. Rao ◽  
David L. Pauls ◽  
Mark W. Hamblin ◽  
David R. Sibley ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Genetic Linkage ◽  
Receptor Gene ◽  
Chromosome 10Q

Prognostic value of loss of chromosome 10q in patients with localized renal cell carcinoma.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 626-626
Author(s):  
Cedric Michel Lebacle ◽  
Aydin Pooli ◽  
Nagesh Rao ◽  
Erika Louise Wood ◽  
Nils Kroeger ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Size ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Chromosome 10Q ◽  
Risk Of Death ◽  
T Stage ◽  
The Impact

626 Background: Several tumor-suppressor genes have been mapped to chromosome 10q, including PTEN. While loss of 10q is a frequently seen cytogenetic abnormality noted to occur in patients with renal cell carcinoma (RCC), little is known about its prognostic significance. We investigated the association of loss of 10q with pathological features and disease-free survival (DFS) in patients with localized RCC. Methods: All patients from UCLA with primary localized RCC who had tumor cytogenetic analysis were included. Alterations in chromosome 10q was specifically reviewed for this study. Logistic regression analyses were used to assess association of loss of 10q with ISUP grading, and T-stage. Cox proportional hazard modeling and Kaplan-Meier analyses were used to assess the impact of loss of 10q on DFS and OS. Recurrence was defined as any local recurrence or development of new metastasis after surgery. Results: A total of 886 patients were included in this study. Loss of 10q occurred in 68 (7.7%) patients and was more commonly seen in chromophobe subtype (24% vs. 6% in non-chromophobe RCC, p < .0001). Loss of 10q was associated with greater tumor size (mean 6.3 vs 5.1 cm, OR = 1.085 [1.024-1.150], p = .008), T3-stage (37% vs 23%, OR = 1.99 [1.17-3.39], p = .011), and ISUP 3-4 (61% vs 37%, OR = 2.64 [1.58-4.40], p < .0001). On survival analysis, after a mean follow-up of 55 months, these patients had a shorter time to recurrence (Log-rank p = .026) and a worse DFS (HR = 2.15 [1.32-3.50], p = .002) than those without loss of 10q. These findings were confirmed on clear-cell RCC subgroup with also a worse OS (HR = 2.00 [1.09-3.67], p = .026) with an estimated 34% risk of death at 5 years for patients with loss of 10q. Conclusions: Loss of chromosome 10q is a prognostic factor associated with larger tumor size, higher grade and T-stage, and worse survival in patients with localized RCC. Identifying patients with loss of 10q can provide additional prognostic information to clinicopathologic variables.

PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo

1999 ◽  
Vol 291 (10) ◽  
pp. 567-569 ◽  
Author(s):  
R. A. Herbst ◽  
E. K. Podewski ◽  
S. Mommert ◽  
A. Kapp ◽  
J. Weiss
Keyword(s):  
Allelic Loss ◽  
Chromosome 10Q
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