scholarly journals Myopathy with hexagonally cross-linked tubular arrays

2020 ◽  
Author(s):  
Keyword(s):  
Tubular Arrays

(EB) Virus: Latency and Expression in Transplanted and Cultured Human Cells

1971 ◽  
Vol 29 ◽  
pp. 368-369
Author(s):  
B. G. Uzman ◽  
M. M. Kasac ◽  
H. Saito ◽  
A. Krishan
Keyword(s):  
Cell Lines ◽  
Primary Cultures ◽  
Virus Particles ◽  
Barr Virus ◽  
Virus Latency ◽  
Virus Surveillance ◽  
Cultured Human Cells ◽  
Epstein Barr ◽  
Serial Transplantation ◽  
Tubular Arrays

In conjunction with the cultivation and transplantation of cells from human tumors by the Programs of Microbiology and Immunogenetics, virus surveillance by electron microscopy has been routinely employed. Of particular interest in this regard have been 3 cell lines cultured from lymph nodes or spleen of 2 patients with Hodgkin's disease and 1 patient with Letterer-Siwe's disease. Each of these cell lines when transplanted in Syrian hamster neonates conditioned with anti-lymphocyte serum grew as serially transplantable tumors; from such transplants of the 3 cell lines cell cultures were retrieved.Herpes type virus particles (Figs. 1, 2, 3) were found in the primary cultures of all three lines, in frozen thawed aliquots of same, and in cultures retrieved from their tumors growing by serial transplantation in hamsters. No virus was detected in sections of 25 of the serially transplanted tumors. However, in 10 such tumors there were repeated instances of tubular arrays in the cisternae of the endoplasmic reticulum (Fig. 4). On serologic examination the herpes virus was shown to be the Epstein-Barr virus.

A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

1981 ◽  
Vol 39 ◽  
pp. 454-455
Author(s):  
C. M. Payne ◽  
P. M. Tennican
Keyword(s):  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Epstein Barr Virus ◽  
Absolute Lymphocyte Count ◽  
Peripheral Blood Lymphocytes ◽  
Clinical State ◽  
Barr Virus ◽  
The Absolute ◽  
Epstein Barr ◽  
Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

Three-dimensional tubular arrays of MnO2–NiO nanoflakes with high areal pseudocapacitance

2012 ◽  
Vol 22 (6) ◽  
pp. 2419-2426 ◽  
Author(s):  
Jinping Liu ◽  
Jian Jiang ◽  
Michel Bosman ◽  
Hong Jin Fan
Keyword(s):  
Three Dimensional ◽  
Tubular Arrays

scholarly journals Parallel tubular arrays in severe combined immunodeficiency disease: an ultrastructural study of peripheral blood lymphocytes

Blood ◽  
1977 ◽  
Vol 50 (1) ◽  
pp. 55-64 ◽  
Author(s):  
CM Payne ◽  
JF Jones ◽  
OF Jr Sieber ◽  
VA Fulginiti
Keyword(s):  
Ultrastructural Study ◽  
Peripheral Blood ◽  
Severe Combined Immunodeficiency ◽  
Peripheral Blood Lymphocytes ◽  
Combined Immunodeficiency ◽  
Circulating Lymphocytes ◽  
Membrane Bound ◽  
Immunodeficiency Disease ◽  
Severe Combined Immunodeficiency Disease ◽  
Tubular Arrays

Abstract The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these inclusions was quite variable, with some attaining a length of 1.7 micrometer. They contained a tubular substructure with a diameter of 36--44 nm. The PTA were mostly located in the centriolar and Golgi regions of the cytoplasm, and were sometimes membrane bound. A centriolar origin of the inclusion was suggested. A second inclusion, the tubuloreticular structure, was found in only 1.4% of the circulating lymphocytes from one SCID patient. The origin of the PTA and its occurrence in severe combined immunodeficiency disease are discussed.

Giant parallel tubular arrays in T lymphocytes

Blood ◽  
2013 ◽  
Vol 121 (3) ◽  
pp. 422-422 ◽  
Author(s):  
David M. Ross ◽  
John Stirling
Keyword(s):  
T Lymphocytes ◽  
Tubular Arrays

Myopathy with hexagonally cross-linked tubular arrays: A new autosomal dominant or sporadic congenital myopathy

1999 ◽  
Vol 45 (4) ◽  
pp. 512-515 ◽  
Author(s):  
Pierre R. Bourque ◽  
Boleslaw Lach ◽  
Stirling Carpenter ◽  
Peter Rippstein
Keyword(s):  
Autosomal Dominant ◽  
Congenital Myopathy ◽  
Tubular Arrays
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