IL12B Gene

2020 ◽  
Author(s):  
Keyword(s):  
Il12b Gene

AB0050 Association of il12b gene polymorphisms with ankylosing spondylitis

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A800.4-A801
Author(s):  
M. Ivanova ◽  
I. Manolova ◽  
L. Miteva ◽  
N. Stoilov ◽  
R. Stoilov ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Gene Polymorphisms ◽  
Il12b Gene

scholarly journals Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains

2002 ◽  
Vol 3 (3) ◽  
pp. 151-157 ◽  
Author(s):  
S I Ymer ◽  
D Huang ◽  
G Penna ◽  
S Gregori ◽  
K Branson ◽  
...  
Keyword(s):  
Mouse Strains ◽  
Il12b Gene

TNFAIP3 and IL12B gene polymorphisms associated with psoriasis vulgaris in an Egyptian cohort

2014 ◽  
Vol 29 (7) ◽  
pp. 1297-1301 ◽  
Author(s):  
O. Haase ◽  
H. Mosaad ◽  
M.A. Eldarouti ◽  
A.Z. Elramly ◽  
N. Samir ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Psoriasis Vulgaris ◽  
Il12b Gene

The IL12B gene does not confer susceptibility to coeliac disease

2002 ◽  
Vol 59 (1) ◽  
pp. 70-72 ◽  
Author(s):  
A.S. Louka ◽  
Å. Torinsson Naluai ◽  
S. D'Alfonso ◽  
H. Ascher ◽  
I. Coto ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Il12b Gene

A 1,100-year-old founder effect mutation in IL12B gene is responsible for Mendelian susceptibility to mycobacterial disease in Tunisian patients

2013 ◽  
Vol 66 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Imen Ben-Mustapha ◽  
Meriem Ben-Ali ◽  
Najla Mekki ◽  
Etienne Patin ◽  
Christine Harmant ◽  
...  
Keyword(s):  
Founder Effect ◽  
Mycobacterial Disease ◽  
Tunisian Patients ◽  
Il12b Gene

scholarly journals Identification of missense mutation in the IL12B gene: lack of association between IL12B polymorphisms and asthma and allergic rhinitis in the Japanese population

2001 ◽  
Vol 2 (7) ◽  
pp. 401-403 ◽  
Author(s):  
E Noguchi ◽  
Y Yokouchi ◽  
M Shibasaki ◽  
M Kamioka ◽  
K Yamakawa-Kobayashi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Missense Mutation ◽  
Japanese Population ◽  
Il12b Gene

scholarly journals Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiao-Lan Li ◽  
Chun-Feng Wu ◽  
Gui-Sheng Wu
Keyword(s):  
Protective Factor ◽  
Chinese Patients ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Control Subjects ◽  
Genetic Patterns ◽  
Il12b Gene ◽  
Genetic And Environmental Factors ◽  
And Control ◽  
Control Study

Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age- and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs: IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27–0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.

scholarly journals Analysis of IL12B Gene Variants in Inflammatory Bowel Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e34349 ◽  
Author(s):  
Jürgen Glas ◽  
Julia Seiderer ◽  
Johanna Wagner ◽  
Torsten Olszak ◽  
Christoph Fries ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gene Variants ◽  
Inflammatory Bowel ◽  
Il12b Gene

scholarly journals Results of Frequency Analysis Distribution of A1188c Rs3212227 Polymorphism in the IL12b Gene among Patients with Chronic Polypoid Rhinosinusit

2021 ◽  
pp. 6-10
Author(s):  
Khasanov Ulugbek Saidakramovich ◽  
◽  
Djuraev Jamolbek Abdukhakhorovich ◽  
Keyword(s):  
Clinical Stage ◽  
Study Groups ◽  
Promoter Regions ◽  
Medical Academy ◽  
Homozygous Genotype ◽  
Multidisciplinary Clinic ◽  
Opposite Situation ◽  
Il12b Gene ◽  
Genotype A ◽  
Group 1

Our data confirm the complexity of the genetic mechanism for the development of polyposis processes in patients with CPRS and indicate the necessity and importance of understanding complex gene interactions in the analysis of the development and clinical stage of the studied pathology. Material and methods. In accordance with the purpose of the study and to fulfill the assigned tasks, clinical studies were carried out in 140 patients with CPRS and with chronic rhinosinusitis, who were examined and treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in 2017-2019. To study the diallelic polymorphism of the promoter regions of the genes of the studied interleukins, 50 healthy (no CPRS) donors, men and women, were examined. The average age of the examined donors was 51.3 ± 1.44 years. Conclusion. Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C / C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. The study of the distribution of genotypes showed that the homozygous genotype A / A was insignificant, almost 1.2 times more often found in group 1 (80.64%), while the frequency of detection of the heterozygous genotype A / C was insignificantly 1.1 times higher among patients with HRC 2 groups. The opposite situation could be observed in the study of the homozygous C / C genotype, which was not identified among all study groups.

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