scholarly journals Nitro-compound Carcinogen

2020 ◽  
Author(s):  
Keyword(s):  
Nitro Compound

scholarly journals Hawk-Seq™ differentiates between various mutations in Salmonella typhimurium TA100 strain caused by exposure to Ames test-positive mutagens

Mutagenesis ◽  
2021 ◽  
Author(s):  
Yuki Otsubo ◽  
Shoji Matsumura ◽  
Naohiro Ikeda ◽  
Osamu Morita
Keyword(s):  
High Resolution ◽  
Salmonella Typhimurium ◽  
Nitro Compound ◽  
Aromatic Amines ◽  
Ames Test ◽  
Alkylating Agents ◽  
Water Soluble ◽  
Base Substitution ◽  
Aromatic Nitro Compound ◽  
Aromatic Nitro

Abstract A precise understanding of differences in genomic mutations according to the mutagenic mechanisms detected in mutagenicity data is required to evaluate the carcinogenicity of environmental mutagens. Recently, we developed a highly accurate genome sequencing method, ‘Hawk-Seq™’, that enables the detection of mutagen-induced genome-wide mutations. However, its applicability to detect various mutagens and identify differences in mutational profiles is not well understood. Thus, we evaluated DNA samples from Salmonella typhimurium TA100 exposed to 11 mutagens including alkylating agents, aldehydes, an aromatic nitro compound, epoxides, aromatic amines, and polycyclic aromatic hydrocarbons (PAHs). We extensively analysed mutagen-induced mutational profiles and their association with the mechanisms of mutagens. Hawk-Seq™ sensitively detected mutations induced by all 11 mutagens, including one that increased the number of revertants by approximately two-fold in the Ames test. Although the sensitivity for less water-soluble mutagens was relatively low, we increased the sensitivity to obtain high-resolution spectra by modifying the exposure protocol. Moreover, two epoxides indicated similar 6-dimensional or 96-dimensional mutational patterns; likewise, three SN1 type alkylating agents indicated similar mutational patterns, suggesting that the mutational patterns are compound category-specific. Meanwhile, an SN2 type alkylating agent exhibited unique mutational patterns compared to those of the SN1 type alkylating agents. Although the mutational patterns induced by aldehydes, the aromatic nitro compound, aromatic amines, and PAHs did not differ substantially from each other, the maximum total base substitution frequencies (MTSFs) were similar among mutagens in the same structural groups. Furthermore, the MTSF was found to be associated with the carcinogenic potency of some direct-acting mutagens. These results indicate that our method can generate high-resolution mutational profiles to identify characteristic features of each mutagen. The detailed mutational data obtained by Hawk-Seq™ can provide useful information regarding mutagenic mechanisms and help identify its association with the carcinogenicity of mutagens without requiring carcinogenicity data.

Active nickel hollow nanosphere supported over SiO2 catalyst for reduction of nitro compound

2021 ◽  
pp. 1-11
Author(s):  
Priyanka S. Pawar ◽  
Aboli A. Lokhande ◽  
Sachin U. Nandanwar ◽  
Prashant S. Niphadkar ◽  
Vijay V. Bokade
Keyword(s):  
Nitro Compound ◽  
Hollow Nanosphere

One-pot tandem catalysis over Pd@MIL-101: boosting the efficiency of nitro compound hydrogenation by coupling with ammonia borane dehydrogenation

2015 ◽  
Vol 51 (52) ◽  
pp. 10419-10422 ◽  
Author(s):  
Qihao Yang ◽  
Yu-Zhen Chen ◽  
Zhiyong U. Wang ◽  
Qiang Xu ◽  
Hai-Long Jiang
Keyword(s):  
Nitro Compound ◽  
Ammonia Borane ◽  
Nitro Compounds ◽  
Tandem Catalysis ◽  
One Pot

The hydrogenation efficiency of nitro compounds is greatly boosted by coupling with ammonia borane dehydrogenation over rationally synthesized Pd@MIL-101 with Pd NPs in ∼3 nm.

The Langmuir–Hinshelwood approach for kinetic evaluation of cucurbit[7]uril-capped gold nanoparticles in the reduction of the antimicrobial nitrofurantoin

2017 ◽  
Vol 19 (29) ◽  
pp. 18913-18923 ◽  
Author(s):  
E. Blanco ◽  
P. Atienzar ◽  
P. Hernández ◽  
C. Quintana
Keyword(s):  
Gold Nanoparticles ◽  
Nitro Compound ◽  
Kinetic Constants ◽  
Kinetic Evaluation ◽  
P Adsorption ◽  
First Time

Adsorption and surface kinetic constants of nitrofurantoin are calculated and compared with those of another nitro compound for the first time.

Effect of Nitro-Compound Smooth Muscle Relaxants and Other Materials on Cyclic GMP Metabolism

1979 ◽  
pp. 123-132 ◽  
Author(s):  
Ferid Murad ◽  
Chandra K. Mittal ◽  
William P. Arnold ◽  
J. Mark Braughler
Keyword(s):  
Smooth Muscle ◽  
Nitro Compound ◽  
Cyclic Gmp ◽  
Muscle Relaxants
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