scholarly journals HLA-DRB1 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Drb1 Gene

Documentation of extensive genetic diversity in the Ovar-DRB1 gene in native Turkish sheep

2021 ◽  
pp. 1-12
Author(s):  
Veysel Bay ◽  
Murat Keleş ◽  
Ramazan Aymaz ◽  
Ecem Hatipoğlu ◽  
Yasemin Öner ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drb1 Gene

scholarly journals The relationship between MHC-DRB1 gene second exon polymorphism and hydatidosis resistance of Chinese merino (Sinkiang Junken type), Kazakh and Duolang sheep

Parasite ◽  
2011 ◽  
Vol 18 (2) ◽  
pp. 163-169 ◽  
Author(s):  
R.Y. Li ◽  
W.Q. Hui ◽  
B. Jia ◽  
G.Q. Shi ◽  
Z.S. Zhao ◽  
...  
Keyword(s):  
Drb1 Gene ◽  
The Relationship

Association of biomarkers of inflammation and HLA-DRB1 gene locus with risk of developing rheumatoid arthritis in females

2019 ◽  
Vol 39 (12) ◽  
pp. 2147-2157 ◽  
Author(s):  
Biljana Klimenta ◽  
Hilada Nefic ◽  
Nenad Prodanovic ◽  
Radivoj Jadric ◽  
Fatima Hukic
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Locus ◽  
Drb1 Gene

Characterization and genotyping of the DRB1 gene of the major histocompatibility complex (MHC) in the Marmota monax, animal model of hepatitis B

2015 ◽  
Vol 63 (2) ◽  
pp. 505-512 ◽  
Author(s):  
Leire Moreno-Cugnon ◽  
Aitor Esparza-Baquer ◽  
Amaia Larruskain ◽  
Koldo García-Etxebarria ◽  
Stephan Menne ◽  
...  
Keyword(s):  
Animal Model ◽  
Major Histocompatibility Complex ◽  
Hepatitis B ◽  
Major Histocompatibility ◽  
Marmota Monax ◽  
Drb1 Gene ◽  
Histocompatibility Complex

Optimization of the MhcOvar-DRB1 gene typing

2006 ◽  
Vol 67 (3) ◽  
pp. 222-228 ◽  
Author(s):  
I. Arrieta-Aguirre ◽  
K. Garcia-Etxebarria ◽  
B. M. Jugo
Keyword(s):  
Drb1 Gene ◽  
Gene Typing

scholarly journals Peculiarities of roentgenological picture of pulmonary tuberculosis upon HLA-DRB1 gene polymorphism depending on pro-and-antiinflammatory cytokines concentration

2018 ◽  
Vol 35 (2) ◽  
pp. 11-18
Author(s):  
N. A. Stepanova ◽  
B. I. Kantemirova ◽  
Kh. M. Galimzyanov
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Lung Tissue ◽  
Specific Treatment ◽  
Cytokine Concentration ◽  
Drb1 Gene ◽  
Cytokine Balance ◽  
Tnf Α ◽  
Standard Values ◽  
Polymerase Chain

Aim. To study the peculiar features of roentgenological picture of pulmonary tuberculosis in patients with polymorphous HLA-DRB1 allels in the genotype in associations with pro-and-antiinflammatory cytokines concentration. Materials and methods. The complex clinicoimmunogenetic examination of 64 patients with pulmonary tuberculosis was carried out. The patients’ age ranged 18 to 52 years. The gene HLA-DRB1 polymorphism was determined using the method of polymerase chain reaction with DNA, previously extracted from blood samples. Cytokine concentration was determined in the peripheral blood before specific treatment, using the assay kits of “Vector-BEST Company” (Russia). Results. The prevailing clinical form of pulmonary tuberculosis among patients was infiltrative one – 40 (62.5). Bacterioexcretion was stated in 89.5 % of cases. Roentgenological picture of pulmonary tuberculosis in patients with HLA-DRB1 *04, *13, *14, *16 alleles was characterized as disseminated injury of lung tissue with destructive changes, the concentration of IL-1b, TNF-α exceeded the standard values by more than 3 times (r = 0.88; р = 0.040), IL-2, IL-10, g-INF was lower than standard values by more than 4–5 times (r = 0.75; р = 0.003). Conclusions. When studying HLA-DRB1 gene polymorphism and pro-and-antiinflammatory cytokines concentrations in patients with pulmonary tuberculosis, it was established that patients with HLA-DRB1 *01, *07, *08, *10, *15 alleles more often, compared to the others, had disseminated injury of lung tissue, in most cases with its destruction as well as dysbalanced cytokine balance in the direction of deep immunosuppression.

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