scholarly journals Mixed Function Oxidase

2020 ◽  
Author(s):  
Keyword(s):  
Mixed Function Oxidase

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

The Effect of Piperonyl Butoxide and Adjuvants on Sulfonylurea Herbicide Activity

1996 ◽  
Vol 10 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Chae Soon Kwon ◽  
Donald Penner
Keyword(s):  
Seed Oil ◽  
Oxidase Inhibitor ◽  
Piperonyl Butoxide ◽  
Mixed Function Oxidase ◽  
Sulfonylurea Herbicide ◽  
Weed Species ◽  
Common Lambsquarters ◽  
Giant Foxtail ◽  
Herbicide Activity ◽  
Grass Weed

Greenhouse studies showed that the mixed function oxidase inhibitor, piperonyl butoxide (PBO), tank-mixed with the sulfonylurea herbicides, nicosulfuron, primisulfuron, and thifensulfuron, in the absence of effective adjuvants enhanced herbicide activity on both broadleaf and grass weed species. Effective adjuvants for nicosulfuron were K-3000 for common lambsquarters, Sylgard® 309 Surfactant for velvetleaf, K-2000 for barnyardgrass, and K-2000, K-3000, and Scoil® methylated seed oil for giant foxtail control. K-3000 and Sylgard 309 enhanced velvetleaf control with primisulfuron and thifensulfuron. The 28% urea and ammonium nitrate (UAN) was more effective as an adjuvant with thifensulfuron for velvetleaf than for common lambsquarters control. The enhancement of sulfonylurea herbicide activity with PBO was most apparent when other adjuvants were least effective.

Changes in the mixed function oxidase enzymes as a result of individual amino acid deficiencies

1977 ◽  
Vol 26 (7) ◽  
pp. 667-670 ◽  
Author(s):  
C.Richard Truex ◽  
Lena Brattsten ◽  
Willard J. Visek
Keyword(s):  
Amino Acid ◽  
Mixed Function Oxidase ◽  
Individual Amino Acid
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