scholarly journals Brittle diabetes

2020 ◽  
Author(s):  
Keyword(s):  
Brittle Diabetes

DIFFERENTIAL DIAGNOSES OF SO-CALLED BRITTLE DIABETES

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S204
Author(s):  
Felix P. N. Schennetten
Keyword(s):  
Differential Diagnoses ◽  
Brittle Diabetes

scholarly journals Inducible Pluripotent Stem Cells as a Potential Cure for Diabetes

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 278
Author(s):  
Kevin Verhoeff ◽  
Sarah J. Henschke ◽  
Braulio A. Marfil-Garza ◽  
Nidheesh Dadheech ◽  
Andrew Mark James Shapiro
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Islet Cells ◽  
Artificial Pancreas ◽  
Glucose Monitoring ◽  
Organ Donor ◽  
Subcutaneous Insulin ◽  
Islet Cell Transplantation ◽  
Brittle Diabetes ◽  
Novel Approach

Over the last century, diabetes has been treated with subcutaneous insulin, a discovery that enabled patients to forego death from hyperglycemia. Despite novel insulin formulations, patients with diabetes continue to suffer morbidity and mortality with unsustainable costs to the health care system. Continuous glucose monitoring, wearable insulin pumps, and closed-loop artificial pancreas systems represent an advance, but still fail to recreate physiologic euglycemia and are not universally available. Islet cell transplantation has evolved into a successful modality for treating a subset of patients with ‘brittle’ diabetes but is limited by organ donor supply and immunosuppression requirements. A novel approach involves generating autologous or immune-protected islet cells for transplant from inducible pluripotent stem cells to eliminate detrimental immune responses and organ supply limitations. In this review, we briefly discuss novel mechanisms for subcutaneous insulin delivery and define their shortfalls. We describe embryological development and physiology of islets to better understand their role in glycemic control and, finally, discuss cell-based therapies for diabetes and barriers to widespread use. In response to these barriers, we present the promise of stem cell therapy, and review the current gaps requiring solutions to enable widespread use of stem cells as a potential cure for diabetes.

A Controlled Study of the Psychoanalytic Treatment of Brittle Diabetes

1991 ◽  
Vol 30 (6) ◽  
pp. 926-935 ◽  
Author(s):  
GEORGE MORAN ◽  
PETER FONAGY ◽  
ANTHONY KURTZ ◽  
ANNE BOLTON ◽  
CHARLES BROOK
Keyword(s):  
Controlled Study ◽  
Brittle Diabetes ◽  
Psychoanalytic Treatment

scholarly journals Brittle diabetes in the elderly

2002 ◽  
Vol 95 (1) ◽  
pp. 58-58 ◽  
Author(s):  
O M P Jolobe ◽  
N Khin
Keyword(s):  
The Elderly ◽  
Brittle Diabetes

Total Pancreatectomy is as Feasible and Safe as Pancreatico-duodenectomy

2019 ◽  
Author(s):  
Offir Ben-Ishay ◽  
Reem Abu Zhaya ◽  
Yoram Kluger
Keyword(s):  
Complication Rate ◽  
Total Pancreatectomy ◽  
Statistical Significance ◽  
Perioperative Outcomes ◽  
Exocrine Insufficiency ◽  
Mortality And Morbidity ◽  
Brittle Diabetes ◽  
Operative Outcomes ◽  
Pancreatic Exocrine ◽  
Control Study

Abstract Background For many years total pancreatectomy (TP) had a notorious reputation due to the resulting brittle diabetes and pancreatic exocrine insufficiency, recent evidence suggests otherwise. The purpose of the current study is to evaluate the comparative perioperative results of TP and pancreatico-duodenectomy (PD).Methods The current study is a single center retrospective, case control study comparing the peri-operative outcomes of TP and PD over a period of 7 years for malignant and benign diseases of the pancreas. Primary and secondary measures of outcome were peri-operative mortality and morbidity respectively.Results 214 patients underwent pancreatic resection during the study period of which 35 patients underwent TP and 179 patients underwent PD. The two groups were homogenous in terms of demographics and clinical presentation. Mortality was not different between TP and PD and stands on 2.9% and 5% respectively (p-0.58). Overall complication rate was significantly lower in the TP group (17.1% vs. 55%, p<0.001) and the rate of major complications (Dindo-Clavien >3) was lower but did not reach statistical significance (2.9% vs. 11.2%, p-0.13).Conclusions Our study suggests that total pancreatectomy is not only feasible and safe, it might have better perioperative outcomes than PD with same mortality and reduced overall complication rate.

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