scholarly journals Potassium Clearance Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Potassium Clearance

Renal regulation of sodium, potassium and chloride balance in single- and twin-pregnant goats

2010 ◽  
Vol 58 (2) ◽  
pp. 199-209 ◽  
Author(s):  
Katarzyna Michałek ◽  
Dorota Jankowiak ◽  
Małgorzata Ożgo ◽  
Wiesław Skrzypczak
Keyword(s):  
Blood Plasma ◽  
Filtration Rate ◽  
Plasma Concentrations ◽  
Chloride Ions ◽  
The Other ◽  
Electrolyte Balance ◽  
Sodium Potassium ◽  
Plasma And Urine Samples ◽  
Potassium Clearance ◽  
Sodium Clearance

The aim of these studies was to analyse and compare changes in selected parameters of renal function in terms of water-electrolyte balance regulation in single- and twin-pregnant goats. Clearance analyses were carried out on 16 pregnant White Improved goats (8 in single and 8 in twin gestation). Blood plasma and urine samples were analysed for the concentration of inulin, endogenous creatinine, sodium, potassium, and chlorides. It has been demonstrated that glomerular filtration rate (GFR) in the goat kidney does not change significantly during gestation. GFR recorded from the 1st week until the 20th week of gestation in twin-pregnant goats was only slightly higher compared to those observed in single-pregnant does. Blood plasma concentrations of major electrolytes, i.e. sodium, potassium and chloride ions, did not differ significantly in pregnant and non-pregnant goats, and remained within the reference values. From the very beginning of gestation, the single-pregnant goats showed increased renal potassium clearance; however, the level of sodium clearance remained stable. On the other hand, sodium clearance increased from the 2nd month of gestation in the twin-pregnant goats, while the load of excreted potassium did not change. These changes had probably resulted from varied levels of aldosterone and progesterone and their mutual proportions differing between the groups.

Parotid Clearance of Sodium and Potassium

1958 ◽  
Vol 195 (3) ◽  
pp. 693-696 ◽  
Author(s):  
L. L. Langley ◽  
C. H. Gunthorpe ◽  
W. A. Beall
Keyword(s):  
Precursor Solution ◽  
Plasma Potassium ◽  
Salivary Flow ◽  
Low Flow ◽  
Parotid Saliva ◽  
Flow Rates ◽  
K Concentration ◽  
Potassium Clearance ◽  
The Relationship ◽  
Sodium And Potassium

A current hypothesis suggests that the mechanism of salivary production involves the formulation of a precursor solution followed by reabsorption of sodium and water but not potassium. Since this is similar to kidney physiology, clearance techniques were used to test the hypothesis. At parotid flow rates below about 0.2 cc/min. the concentration of Na varies directly and that of K indirectly with the flow. At higher rates the K concentration is independent of the flow and closely approximates that of the plasma. Potassium clearance, then, is independent of flow only at very low flows. The concentration of Na in parotid saliva varies with that in the plasma. Extrapolation of the curve cuts the abscissa at a point indicating that if the plasma Na concentration were reduced below approximately 100 mEq/l. no Na would appear in the saliva. The relationship between plasma concentration and the saliva Na/plasma Na ratio is an ascending curve. As the plasma K concentration increases so does the concentration in the parotid saliva. Extrapolation of this curve approaches the origin. The saliva K/plasma K ratio is independent of the plasma K concentration. When K is infused salivary flow rate increases. The infusion of Na decreases flow. These results are consistent with the selective reabsorption theory at low flow rates but there must be another mechanism to explain the findings at higher flows. It is suggested that the influence of Na and K infusion on salivation may be, at least partially, indirect.

Kidney Function in the Adult Rat

1956 ◽  
Vol 186 (1) ◽  
pp. 172-174 ◽  
Author(s):  
Julian Jacobs ◽  
J. H. U. Brown
Keyword(s):  
Creatinine Clearance ◽  
Kidney Function ◽  
Adult Rat ◽  
Endogenous Creatinine Clearance ◽  
Potassium Clearance ◽  
Sodium And Potassium

Endogenous creatinine clearance of the adult rat has been determined to be 0.556 ml/min/100 gm B. W. This value must be increased about 25% in order to obtain ‘true’ creatinine clearances. Large doses of atropine or hexamethonium decreased the creatinine, sodium and potassium clearances. The clearance of sodium was decreased to a greater extent than was the creatinine or potassium clearance. The urinary Na/K ratio was also decreased in the presence of both drugs.

Effects of glucocorticoid steroids on renal and systemic acid-base metabolism

1980 ◽  
Vol 239 (1) ◽  
pp. F30-F43 ◽  
Author(s):  
H. N. Hulter ◽  
J. H. Licht ◽  
E. L. Bonner ◽  
R. D. Glynn ◽  
A. Sebastian
Keyword(s):  
Steady State ◽  
Acid Production ◽  
Chronic Administration ◽  
Acid Excretion ◽  
Acid Base ◽  
Unmeasured Anion ◽  
Urine Ph ◽  
Group I ◽  
Potassium Clearance ◽  
Net Acid Excretion

Clinical states of hyperglucocorticoidism are associated with renal metabolic alkalosis, yet the systemic and renal acid-base response to chronic administration of glucocorticoid steroids (dexamethasone, triamcinolone) possessing little or no mineralocorticoid activity has not been investigated. In balance studies studies in dogs administration of triamcinolone (Tcn), 1.0 mg. kg-1. day-1 for 6–9 days (group I, n = 5), resulted in a persistent reduction in urine pH and increase in net acid excretion (NAE), and in the excretion of urinary unmeasured anions (C+NH4,Na;K minus A-Cl,HCO3,Pi), which were identified as organic anions and sulfate. A significant degree of metabolic acidosis occurred initially (delta [HCO3-]p, -3.4 meq/liter, P less than 0.05, day 1). As Tcn administration was continued, the cumulative increment in net acid excreted exceeded the cumulative increment in urinary unmeasured anion excreted and [HCO-3]p returned to pre-Tcn control values and remained stable thereafter. In the steady state of Tcn administration plasma potassium concentration and renal potassium clearance were not significantly different from pre-Tcn control, in contrast to the findings of hypokalemia and increased renal potassium clearance during chronic administration of deoxycorticosterone (DOC). Triamcinolone did not result in antinatriuresis or antichloruresis. Chronic administration of a 10–fold smaller dose of Tcn (0.1 mg . kg-1 . day-1) in an additional group (group III) also resulted in a persisting reduction in urine pH and an increase in net acid excretion that exceeded unmeasured anion excretion and resulted in a small increase in steady-state plasma bicarbonate concentration. These results suggest that chronic administration of potent glucocorticoid steroids results in 1) a persisting increase in endogenous acid production, and 2) stimulation of renal hydrogen ion secretion that was of greater degree than accounted for by the increment in endogenous acid production and that was not accompanied by renal mineralocorticoid effects on sodium and potassium transport.

Sign in / Sign up

Export Citation Format

Share Document