Solitary Breast Cyst

2020 ◽  
Author(s):  
Keyword(s):  
Breast Cyst

Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy

1994 ◽  
Vol 1 (2) ◽  
pp. 49-55 ◽  
Author(s):  
I Számel ◽  
B Budai ◽  
K Daubner ◽  
J Kralovánszky ◽  
Sz Ottó ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sex Steroids ◽  
Linear Regression Analysis ◽  
Cyst Fluid ◽  
Type I ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Apocrine Metaplasia ◽  
Endocrine Parameters

ABSTRACT Gross cystic disease (GCD) of the breast may be associated with a higher risk for the development of breast cancer. High levels of sex steroids, steroid hormone precursors, prolactin and cations have been found in breast cyst fluid (BCF) by several investigators. Accordingly, endocrine parameters and the cationic composition of BCF may be considered as useful characteristics to follow patients bearing macrocysts. In this study we have investigated the concentrations of estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHA) and DHA-3-sulfate (DHA-S), prolactin, potassium (K+) and sodium (Na+) in BCF aspirated from 99 women. The mean age of the patients was 49.8 years (range 32-58). The hormone levels were measured by RIA methods; K+ and Na+ were determined by flame photometry. Estradiol, progesterone, testosterone, DHA, DHA-S, prolactin and K+ showed significant accumulation in the BCF compared with their respective serum values. The K+/Na+ ratio proved to be useful in dividing cysts into type I (≥1), type II (<1 but ≥0.1) and type III (<0.1) subgroups. For type I BCF, higher DHA, DHA-S and prolactin concentrations were detected. Linear regression analysis established a highly significant (P<0.001) correlation between the concentrations of E2 and DHA-S (r=0.686), and also between testosterone and DHA-S (r=0.711). These findings indicate that type I BCF might be a marker for 'active' GCD of the breast, and suggest that it may be associated with an increased breast cancer risk, since this group of patients is supposed to have cysts with apocrine metaplasia. It is suggested therefore that when BCF is aspirated, sex steroids, steroid precursors and cations should be routinely measured, and women with type I cysts should be regularly examined.

Estroe-3-Sulfate in Human Breast Cyst Fluid

1990 ◽  
Vol 595 (1 Steroid Forma) ◽  
pp. 464-466 ◽  
Author(s):  
F. Orlandi ◽  
P. Caraci ◽  
B. Puligheddu ◽  
M. Torta ◽  
L. Dogliotti ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Apocrine cells in breast cyst fluid and their relationship to cyst type: A morphometric Study

1988 ◽  
Vol 24 (4) ◽  
pp. 597-602 ◽  
Author(s):  
Donatella Beccati ◽  
Nadia Grilli ◽  
Patrizia Schincaglia ◽  
Carlo Naldoni ◽  
Licia Tavolazzi ◽  
...  
Keyword(s):  
Type A ◽  
Cyst Fluid ◽  
Morphometric Study ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Cyst Type

Quantification of prostate-specific antigen immunoreactivity in human breast cyst fluids

1996 ◽  
Vol 38 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Ferdinando Mannello ◽  
GianDomenico Bocchiotti ◽  
Giuseppe Bianchi ◽  
Francesco Marcheggiani ◽  
Giancarlo Gazzanelli
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Human Breast ◽  
Breast Cyst ◽  
Cyst Fluids

Steroid Hormones in Breast Cyst Fluids

1990 ◽  
Vol 586 (1 Biochemistry) ◽  
pp. 60-69 ◽  
Author(s):  
W. R. MILLER ◽  
W. N. SCOTT ◽  
R. W. KELLY ◽  
R. A. HAWKINS
Keyword(s):  
Steroid Hormones ◽  
Breast Cyst ◽  
Cyst Fluids

Catecholestrogen Content and Ratios in Breast Cyst Fluid

1990 ◽  
Vol 595 (1 Steroid Forma) ◽  
pp. 455-458
Author(s):  
O. M. Granata ◽  
F. Arcuri ◽  
E. Fecarotta ◽  
G. Brignone ◽  
L. Blasi ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst

scholarly journals Ultrasonic Measurement of Temperature Rise in Breast Cyst and in Neighbouring Tissues as a Method of Tissue Differentiation

2016 ◽  
Vol 41 (4) ◽  
pp. 791-798 ◽  
Author(s):  
Barbara Gambin ◽  
Michał Byra ◽  
Eleonora Kruglenko ◽  
Olga Doubrovina ◽  
Andrzej Nowicki
Keyword(s):  
Probability Density ◽  
Breast Tissue ◽  
Tissue Characterization ◽  
Heating Process ◽  
Ultrasound Images ◽  
Bioheat Equation ◽  
Acoustical Properties ◽  
Breast Cyst ◽  
Malignant Lesions ◽  
Backscattered Signals

Abstract Texture of ultrasound images contain information about the properties of examined tissues. The analysis of statistical properties of backscattered ultrasonic echoes has been recently successfully applied to differentiate healthy breast tissue from the benign and malignant lesions. We propose a novel procedure of tissue characterization based on acquiring backscattered echoes from the heated breast. We have proved that the temperature increase inside the breast modifies the intensity, spectrum of the backscattered signals and the probability density function of envelope samples. We discuss the differences in probability density functions in two types of tissue regions, e.g. cysts and the surrounding glandular tissue regions. Independently, Pennes bioheat equation in heterogeneous breast tissue was used to describe the heating process. We applied the finite element method to solve this equation. Results have been compared with the ultrasonic predictions of the temperature distribution. The results confirm the possibility of distinguishing the differences in thermal and acoustical properties of breast cyst and surrounding glandular tissues.

scholarly journals SAT-006 A New Concept for the Endocrinology of Pre-Eclampsia: The Role of Spiral Steroids

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Fred I Chasalow ◽  
Ron Bochner
Keyword(s):  
Type A ◽  
Structural Features ◽  
Type B ◽  
Salt Diet ◽  
Breast Cyst ◽  
High K ◽  
Epithelial Na Channels ◽  
Low Salt

Abstract Background: In 1987, Graves observed that during the 3rd trimester, some patients with pre-eclampsia had high levels of unknown materials that could be detected with assays for digoxin (DLM). In 2018, we characterized a new candidate for the DLM, Ionotropin. It is a phosphocholine (PC) ester of a novel steroid with 23 carbon atoms. As Ionotropin shares structural features (a) with spironolactone (both have spiral lactones in the E-ring) and (b) with digoxin (E-ring lactone and 3α-5β configuration), we have proposed that Ionotropin may function as a potassium (K+) sparing diuretic. This suggestion is supported by the observations that [1] patients who cannot make Ionotropin (7-dehydrosterol reductase deficiency) are K+ wasting and [2] breast cyst fluids with high K+ levels also have high Ionotropin levels. Hypothesis: During the 3rd trimester, fetal requirements for K+ reach a maximum, fetal blood pressure increases and aldosterone signaling is blocked. This blockage leads to fetal sodium (Na+) wasting and is essential for formation of amniotic fluid. These events are consistent with a normal role for an unknown endogenous K+ sparing hormone and would be the basis for a modest elevation of maternal DLM during the 3rd trimester. Our hypothesis is that if any of the functions were inadequate, then the fetal-placental unit would synthesize excess PC-spiral steroids; the woman would exhibit symptoms of K+ sparing hormone excess (hypertension and proteinuria) and would be diagnosed with pre-eclampsia. Experimental Results: We have just reported a pilot study associating elevated PC esters of spiral steroids in women with pre-eclampsia. In brief, 12 of 19 women had elevated levels of at least one of the PC steroids (Z-score &gt; 2) when compared to the levels in 20 pregnant women matched for gestational age and fetal sex. There are two basic mechanisms for this dichotomy: (a) there may be episodic secretion with of a DLM with a short half-life or (b) there may be two different underlying biochemical causes. In prior studies, there has been no indication of episodic secretion of DLM similar to that observed with glucocorticoids, Ionotropin or other PC spiral steroids. Discussion: There are two basic types of K+ sparing diuretics. Type A: Spironolactone functions by regulating the NaK-ATPase. Type B: Triamterene functions by blocking synthesis of epithelial Na+ channels. Thus, Type A would have high levels of spiral steroids and Type B would have low levels of spiral steroids. Type A patients would be expected to have higher risk of long-term consequences when compared to the Type B patients. Conclusion: The recognition of the division of pre-eclampsia into two separate diseases might be the key observation for developing Type-specific diagnosis and therapy. For example, a Type A patient might benefit from a low salt diet but that diet would not be expected to benefit a patient with Type B disease.

Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast

Cancer ◽  
1983 ◽  
Vol 51 (7) ◽  
pp. 1297-1302 ◽  
Author(s):  
John S. Silva ◽  
Gregory S. Georgiade ◽  
William G. Dilley ◽  
Kenneth S. McCarty ◽  
Samuel A. Wells ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Steroid Receptors ◽  
Cyst Fluid ◽  
Sex Steroid ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Normal Human Breast ◽  
Normal Human ◽  
Cycle Dependent
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