scholarly journals Penis Erectile Tissue

2020 ◽  
Author(s):  
Keyword(s):  
Erectile Tissue

1059: In Vivo Analysis of Chronic Phosphodiesterase-5 Inhibition in Penile Erectile Tissue: No Tachyphylaxis Effect

2005 ◽  
Vol 173 (4S) ◽  
pp. 287-287
Author(s):  
Anhur L. Burnett ◽  
Hunter C. Champion ◽  
Robyn E. Becker ◽  
Melissa F. Kramer ◽  
Tongyun Liu ◽  
...  
Keyword(s):  
Erectile Tissue ◽  
In Vivo Analysis ◽  
Phosphodiesterase 5

1423: PDE5 Dysregulation in Penile Erectile Tissue: Mechanism of Priapism

2004 ◽  
Vol 171 (4S) ◽  
pp. 375-375
Author(s):  
Trinity J. Bivalacqua ◽  
Hunter C. Champion ◽  
Eiki Takimoto ◽  
David Kass ◽  
Arthur L. Burnett
Keyword(s):  
Erectile Tissue

Aspects of reproduction, and morphology of the penis, of Pseudantechinus woolleyae (Marsupialia : Dasyuridae)

2017 ◽  
Vol 65 (6) ◽  
pp. 357 ◽  
Author(s):  
P. A. Woolley
Keyword(s):  
Western Australia ◽  
Arid Regions ◽  
Wide Distribution ◽  
Erectile Tissue ◽  
Australian Museum ◽  
Seasonal Breeder ◽  
Males And Females ◽  
One Year ◽  
Western Australian

Woolley’s Pseudantechinus, P. woolleyae, has remained virtually unstudied in the 30 years since its recognition in 1988 as a species distinct from P. macdonnellensis. It has a wide distribution in arid regions of Western Australia. What little is known of its biology comes largely from studies carried out over the years 1988–91 on one wild-caught female and her offspring, and a few specimens held in the collection of the Western Australian Museum. P. woolleyae is a seasonal breeder and young are born from late July to early October. They mature when ~7 months old. Both males and females are potentially capable of breeding in more than one year. Males have accessory erectile tissue that does not form an appendage on the penis.

In vitro effects of a novel class of no donating compounds on isolated human erectile tissue

2002 ◽  
Vol 1 (1) ◽  
pp. 64 ◽  
Author(s):  
Stefan Ückert ◽  
Michael Seidler ◽  
Björn Ness ◽  
Christian Stief ◽  
Dimitrios Tsikas ◽  
...  
Keyword(s):  
Erectile Tissue ◽  
In Vitro Effects

Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum

2014 ◽  
Vol 307 (10) ◽  
pp. H1393-H1400 ◽  
Author(s):  
Fábio H. Silva ◽  
Carolina Lanaro ◽  
Luiz Osório Leiria ◽  
Renata Lopes Rodrigues ◽  
Ana Paula Davel ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Superoxide Anion ◽  
Middle Age ◽  
Corpus Cavernosum ◽  
Soluble Guanylyl Cyclase ◽  
Middle Aged ◽  
Sympathetic Hyperactivity ◽  
Aged Group ◽  
Erectile Tissue ◽  
Th Mrna

Impairment of nitric oxide (NO)-mediated cavernosal relaxations in middle age contributes to erectile dysfunction. However, little information is available about the alterations of sympathetic neurotransmission and contraction in erectile tissue at middle age. This study aimed to evaluate the alterations of the contractile machinery associated with tyrosine hydroxylase (TH) in rat corpus cavernosum (RCC) at middle age, focusing on the role of superoxide anion. Male Wistar young (3.5-mo) and middle-aged (10-mo) rats were used. Electrical-field stimulation (EFS)- and phenylephrine-induced contractions were obtained in RCC strips. Levels of reactive-oxygen species (ROS) and TH mRNA expression, as well as protein expressions for α1/β1-subunits of soluble guanylyl cyclase (sGC), in RCC were evaluated. The neurogenic contractile responses elicited by EFS (4–32 Hz) were greater in RCC from the middle-aged group that was accompanied by elevated TH mRNA expression ( P < 0.01). Phenylephrine-induced contractions were also greater in the middle-aged group. A 62% increase in ROS generation in RCC from middle-aged rats was observed. The mRNA expression for the α1A-adrenoceptor remained unchanged among groups. Protein levels of α1/β1-sGC subunits were decreased in RCC from the middle-aged compared with young group. The NADPH oxidase inhibitor apocynin (85 mg·rat−1·day−1, 4 wk) fully restored the enhanced ROS production, TH mRNA expressions, and α1/β1-subunit sGC expression, indicating that excess of superoxide anion plays a major role in the sympathetic hyperactivity and hypercontractility in erectile tissue at middle age. Reduction of oxidative stress by dietary antioxidants may be an interesting approach to treat erectile dysfunction in aging population.

PS-04-005 Low intensity Shockwave Therapy (LiST) may promote angiogenesis and alter a1/a2 adrenergic receptors ratio in the erectile tissue of naturally aged rats

2019 ◽  
Vol 16 (5) ◽  
pp. S12
Author(s):  
I. Sokolakis ◽  
F. Dimitriadis ◽  
D. Psalla ◽  
G. Karakiulakis ◽  
G. Hatzichristodoulou ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Aged Rats ◽  
Erectile Tissue ◽  
Shockwave Therapy ◽  
Low Intensity

scholarly journals The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts

2020 ◽  
Vol 9 (9) ◽  
pp. 2987
Author(s):  
George T. Kedia ◽  
Stefan Ückert ◽  
Dimitrios Tsikas ◽  
Armin J. Becker ◽  
Markus A. Kuczyk ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Erectile Dysfunction ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Smooth Muscle Relaxation ◽  
Vasoactive Drugs ◽  
Erectile Tissue ◽  
Orally Active

It is widely accepted that disorders of the male (uro)genital tract, such as erectile dysfunction (ED) and benign diseases of the prostate (lower urinary tract symptomatology or benign prostatic hyperplasia), can be approached therapeutically by influencing the function of both the vascular and non-vascular smooth muscle of the penile erectile tissue or the transition zone/periurethral region of the prostate, respectively. As a result of the discovery of nitric oxide (NO) and cyclic guanosine monophosphate (GMP) as central mediators of penile smooth muscle relaxation, the use of drugs known to increase the local production of NO and/or elevate the intracellular level of the second messenger cyclic GMP have attracted broad attention in the treatment of ED of various etiologies. Specifically, the introduction of vasoactive drugs, including orally active inhibitors of the cyclic GMP-specific phosphodiesterase (PDE) 5, has offered great advantage in the pharmacotherapy of ED and other diseases of the genitourinary tract. These drugs have been proven efficacious with a fast on-set of action and an improved profile of side-effects. This review summarizes current strategies for the treatment of ED utilizing the application of vasoactive drugs via the oral, transurethral, topical, or self-injection route.

Erectile dysfunction: an early marker for hypertension? A longitudinal study in spontaneously hypertensive rats

2005 ◽  
Vol 288 (1) ◽  
pp. R276-R283 ◽  
Author(s):  
Delphine Behr-Roussel ◽  
Diane Gorny ◽  
Katell Mevel ◽  
Sandrine Compagnie ◽  
Patrick Kern ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Vascular Tissue ◽  
Spontaneously Hypertensive Rat ◽  
Warning Sign ◽  
Aortic Tissue ◽  
Spontaneously Hypertensive ◽  
Erectile Tissue ◽  
Early Warning Sign ◽  
History Of ◽  
Wistar Kyoto

Erectile dysfunction (ED) is another manifestation of vascular disease. We evaluated the natural history of ED in the spontaneously hypertensive rat (SHR) and the respective participation of associated pathophysiological modifications, i.e., endothelial dysfunction and tissue remodeling. SHR and their normotensive counterparts [Wistar-Kyoto rats (WKY)] of 6, 12, and 24 wk of age ( n = 12) were used to evaluate erectile function, erectile and aortic tissue reactivity, and remodeling. Erectile responses in SHR are reduced at all ages ( P < 0.001). In both aortic and erectile tissues of SHR and WKY, relaxations to ACh are altered progressively with age, although more markedly in SHR. They are decreased at 12 wk of age in erectile tissue of SHR compared with WKY (maximal relaxation: −19.2 ± 2.8% vs. −28.3 ± 3.9%, P < 0.001) but only at 24 wk of age in aortas (−47.9 ± 6.4% vs. −90.5 ± 2.9%, P < 0.001). Relaxations to sodium nitroprusside are unaltered in aortic rings of both strains but enhanced in erectile tissue of SHR at 12 wk of age. Major modifications in the distribution of collagen I, III, and V in SHR occur in both types of tissue and are detectable sooner in erectile tissue compared with aortic tissue. The onset of ED is detectable before the onset of hypertension in the SHR. Structural and functional alterations, while similar, occur earlier in erectile compared with vascular tissue. If confirmed in humans, ED could be an early warning sign for hypertension, and common therapeutic strategies targeting both ED and hypertension could be investigated.

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