scholarly journals Hyponatraemia – drug-related side effect in older adults

2019 ◽  
Vol 75 (2) ◽  
pp. 103-108
Author(s):  
Jolanta Szymańska
Keyword(s):  
Older Adults ◽  
Side Effect ◽  
Drug Related Side Effect

Hearing impairments and their treatments

2017 ◽  
pp. 1171-1176
Author(s):  
Sara K. Mamo ◽  
Theresa H. Chisolm ◽  
Frank R. Lin
Keyword(s):  
Older Adults ◽  
Primary Care ◽  
Hearing Loss ◽  
Side Effect ◽  
Care Management ◽  
Geriatric Care ◽  
Hearing Impairments ◽  
Age Related ◽  
Age Related Hearing Loss ◽  
Primary Care Management

Hearing loss is highly prevalent and increases as a function of age. Although hearing loss affects many aspects of ageing and communication, it is often overlooked and treated as a rather inconsequential side effect of ageing. The purpose of this chapter is to introduce age-related hearing loss, the broader implications of age-related hearing loss as it relates to healthy ageing, and practical strategies for primary care management of hearing loss. A majority of the cases of age-related hearing loss remain untreated. Primary and/or geriatric care clinics may serve as the entry point for many older adults with hearing loss. Including questions about hearing loss or screening for hearing loss at other health encounters may increase access for older adults to hearing loss treatment.

Characteristics of patients hospitalized through the emergency department with an oncology drug-related side effect.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 6557-6557
Author(s):  
Elisea Avalos-Reyes ◽  
Darren Parke ◽  
Kirsten Wallace ◽  
Allison Freeman ◽  
Kjel Andrew Johnson
Keyword(s):  
Emergency Department ◽  
Drug Treatment ◽  
Cancer Patients ◽  
Health Plan ◽  
Side Effect ◽  
Inpatient Admission ◽  
Oncology Drug ◽  
Increased Risk ◽  
Ed Visits ◽  
Drug Related Side Effect

6557 Background: Recent advances in oncology treatment present an expanding spectrum of cancer-treatment-related emergencies.Many aspects of healthcare utilization, specifically emergency department (ED) visits, are not well studied in this population. The purpose of this study is to determine (1) what proportion of cancer patients visit the ED with an oncology drug-related side effect and are admitted and (2) what factors impact the probability of inpatient admission among these patients. Methods: This study evaluated ED visits by adult patients undergoing active drug treatment for cancer insured by a large commercial and Medicare health plan in the United States between January 1, 2018, and September 30, 2019. Among cancer-related ED visits, logistic regression was used to determine the marginal effect of demographic and clinical characteristics of patients on acute inpatient admission. Results: There were 39,921 total ED visits among patients undergoing drug treatment for cancer; of these, 76% presented with an oncology drug-related side-effect. 36% of all ED visits resulted in admission, 5% resulted in an observation stay. After adjusting, age was not a significant predictor of inpatient admission. Being male (p < 0.01) and living in urban (p < 0.01) or suburban (p < 0.01) zip codes significantly increased the likelihood of admission. Patients with colorectal (p = 0.019), gastrointestinal (p < 0.01), blood (p < 0.01), lung (p < 0.01), metastatic (p < 0.01) cancers, or Hodgkin’s lymphoma (p < 0.01) had significantly increased risk of admission. Patients with prostate (p < 0.01) cancer had a significantly reduced risk of admission. The primary complaint upon presentation to the ED was the most important predictor of inpatient admission; sepsis, pneumonia, medical complications, white cell disorders, metastatic cancer, and fractures were all associated with a significantly higher (all p < 0.001) risk of admission. Patients with comorbid heart failure (p < 0.001), those taking ulcer medications (p < 0.01), or inflammatory bowel disease (p = 0.03) had a significantly increased risk of admission. Results were consistent regardless of payer (Medicare or commercial health plan). Conclusions: This study identified cancer patients for whom acute inpatient admission from an ED presentation is more likely. Future studies identifying cancer patients who may be at risk of making an ED presentation based on demographic, clinical and disease-related characteristics are needed and may help inform targeted follow up of patients to mitigate potentially avoidable ED presentation and subsequent inpatient admission.

scholarly journals Role of GandharvaHasta Tail in Geriatric Constipation - A Case Study

2018 ◽  
Vol 6 (06) ◽  
Author(s):  
Kranti N. Khekale
Keyword(s):  
Older Adults ◽  
Side Effect ◽  
Single Case ◽  
The Elderly ◽  
Sweet Taste ◽  
Over The Counter ◽  
Evidence Based Treatment ◽  
Common Complaint

Constipation is a common complaint in older adults. Although constipation is not a physiologic consequence of normal aging, decreased mobility and other medical conditions may contribute to its increased prevalence in older adults. The prevalence of constipation rises dramatically with age, with some estimates approaching 50% among adults over 80 years of age. There are a variety of over-the-counter and prescription laxatives available for the treatment of constipation. There are many laxatives sold in the market. They have not been studied in controlled trials to make a recommendation. Its side effect may be harmful to patient. There is no one best evidence-based treatment for chronic constipation in the elderly. this study, shows single case of geriatric patient suffering from constipation wherein  Gandharvahasta tailwas given 10ml orally. The reference of Gandharvahasta tail is  Bhaishajya Ratanavali. Gandharvahasta tail acts as mild laxative with sweet taste, pleasant smell. Gandharvahasta Tail shows significant result with no side effect. It is easily palatable so there is no compliant for taking medicine.

scholarly journals Depression, antidepressants and fall risk: therapeutic dilemmas—a clinical review

2021 ◽  
Author(s):  
E. P. van Poelgeest ◽  
A. C. Pronk ◽  
D. Rhebergen ◽  
N. van der Velde
Keyword(s):  
Older Adults ◽  
Decision Making ◽  
Clinical Review ◽  
Side Effect ◽  
Fall Risk ◽  
Older Persons ◽  
Clinical Decision Making ◽  
Elderly Persons ◽  
Side Effect Profile ◽  
Antidepressant Use

Abstract Purpose The aim of this clinical review was to summarize the existing knowledge on fall risk associated with antidepressant use in older adults, describe underlying mechanisms, and assist clinicians in decision-making with regard to (de-) prescribing antidepressants in older persons. Methodology We comprehensively examined the literature based on a literature search in Pubmed and Google Scholar, and identified additional relevant articles from reference lists, with an emphasis on the most commonly prescribed drugs in depression in geriatric patients. We discuss use of antidepressants, potential fall-related side effects, and deprescribing of antidepressants in older persons. Results Untreated depression and antidepressant use both contribute to fall risk. Antidepressants are equally effective, but differ in fall-related side effect profile. They contribute to (or cause) falling through orthostatic hypotension, sedation/impaired attention, hyponatremia, movement disorder and cardiac toxicity. Falling is an important driver of morbidity and mortality and, therefore, requires prevention. If clinical condition allows, withdrawal of antidepressants is recommended in fall-prone elderly persons. An important barrier is reluctance of prescribers to deprescribe antidepressants resulting from fear of withdrawal symptoms or disease relapse/recurrence, and the level of complexity of deprescribing antidepressants in older persons with multiple comorbidities and medications. Practical resources and algorithms are available that guide and assist clinicians in deprescribing antidepressants. Conclusions (De-) prescribing antidepressants in fall-prone older adults is often challenging, but detailed insight in fall-related side effect profile of the different antidepressants and a recently developed expert-based decision aid STOPPFalls assists prescribers in clinical decision-making.

scholarly journals Changes in daily loneliness for German residents during the first four weeks of the COVID-19 pandemic

2020 ◽  
Author(s):  
Susanne Buecker ◽  
Kai Tobias Horstmann ◽  
Julia Krasko ◽  
Sarah Kritzler ◽  
Sophia Terwiel ◽  
...  
Keyword(s):  
Older Adults ◽  
Empirical Evidence ◽  
Psychological Functioning ◽  
Side Effect ◽  
Large Scale ◽  
Daily Diary ◽  
Diary Study ◽  
Social Lives ◽  
Daily Diary Study

The coronavirus disease 2019 (Covid-19) outbreak has dramatically altered people’s social lives due to strict distancing policies. Increased loneliness has been publicly discussed as a harmful psychological side effect of these policies. However, thus far, empirical evidence was lacking. This large scale daily diary study assessed daily loneliness in N = 4,850 German adults from March 16, 2020 until April 12, 2020. Daily loneliness increased during the first two weeks of the Covid 19 lockdown and decreased thereafter. We identified subgroups that are at a higher risk for changes in daily loneliness during the Covid-19 pandemic (i.e., older adults, parents). It is important to evaluate if and how established knowledge about psychological functioning applies to extraordinary times and events such as the Covid-19 pandemic.

scholarly journals Older Adults Encode Task-Irrelevant Stimuli, but Can This Side-Effect be Useful to Them?

2020 ◽  
Vol 14 ◽  
Author(s):  
Zsófia Anna Gaál ◽  
Boglárka Nagy ◽  
Domonkos File ◽  
István Czigler
Keyword(s):  
Older Adults ◽  
Side Effect ◽  
Encode Task ◽  
Task Irrelevant

Flurbiprofen-induced generalized bullous fixed drug eruption

2013 ◽  
Vol 33 (1) ◽  
pp. 106-108 ◽  
Author(s):  
I Balta ◽  
H Simsek ◽  
GG Simsek
Keyword(s):  
Contact Dermatitis ◽  
Side Effect ◽  
Drug Eruption ◽  
Cutaneous Vasculitis ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Drug Related Side Effect ◽  
Erythematous Patch

Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.

scholarly journals COGNITIVE AND SUBJECTIVE EFFECTS OF OXYCODONE IN OLDER ADULTS WITH HEALTHY AND UNHEALTHY ALCOHOL PATTERNS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S890-S890
Author(s):  
Monique Cherrier ◽  
Gregory Terman ◽  
Danny Shen ◽  
Laura Shireman ◽  
Andrew Saxon ◽  
...  
Keyword(s):  
Older Adults ◽  
Alcohol Consumption ◽  
Side Effect ◽  
Middle Age ◽  
Subjective Effects ◽  
Laboratory Model ◽  
Subjective Rating ◽  
Heavy Alcohol ◽  
Unhealthy Alcohol ◽  
The Impact

Abstract Chronic unhealthy levels of alcohol use, may predispose adults to use illicit substances and/or modify their response to prescribed medications, such as pain medications. We examined the cognitive and side effect response of older adults who met criteria for healthy and unhealthy alcohol drinking patterns after exposure to 10mg of oxycodone. Using a human laboratory model, eligible participants were characterized on cognitive, side effect measures and cold-pressor pain test (CPT) at baseline and repeated 90 minutes, 3 and 5 hours post dosing (10mg oxycodone). Blood samples were taken at regular intervals to measure drug levels. One-hundred twenty-five adults completed the study day, eighty participants with heavy alcohol consumption and 45 with healthy. Middle age (MA) group had a mean age of 51 (11.2) years, older adults (OA) 72 (4.2) years. Between group (unhealthy vs healthy drinkers, middle age vs older adult) comparisons for cognitive performance indicate a significant decline at 90 min. However, MA and OA heavy alcohol consumers evidenced less decline on sustained attention (D2) and working memory, but more decline on a measure of balance (berg). Anti-nocioceptive effects were greatest in healthy (MA,OA) in comparison to heavy, however there were no differences on pupil miosis. Subjective rating of side effects were rated more severe in the OA unhealthy group compared to MA and healthy. These findings indicate unhealthy alcohol consumption attenuates the impact of opioid medication. Results indicate that alcohol consumption patterns should be considered when using opioids in older and middle age adults.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Cognitive Load Affects Speech Motor Performance Differently in Older and Younger Adults

2019 ◽  
Vol 62 (5) ◽  
pp. 1258-1277 ◽  
Author(s):  
Megan K. MacPherson
Keyword(s):  
Older Adults ◽  
Cognitive Load ◽  
Motor Performance ◽  
Age Groups ◽  
Incongruent Condition ◽  
Sentence Production ◽  
Movement Duration ◽  
Production Task ◽  
Younger Adults ◽  
Speech Motor

PurposeThe aim of this study was to determine the impact of cognitive load imposed by a speech production task on the speech motor performance of healthy older and younger adults. Response inhibition, selective attention, and working memory were the primary cognitive processes of interest.MethodTwelve healthy older and 12 healthy younger adults produced multiple repetitions of 4 sentences containing an embedded Stroop task in 2 cognitive load conditions: congruent and incongruent. The incongruent condition, which required participants to suppress orthographic information to say the font colors in which color words were written, represented an increase in cognitive load relative to the congruent condition in which word text and font color matched. Kinematic measures of articulatory coordination variability and movement duration as well as a behavioral measure of sentence production accuracy were compared between groups and conditions and across 3 sentence segments (pre-, during-, and post-Stroop).ResultsIncreased cognitive load in the incongruent condition was associated with increased articulatory coordination variability and movement duration, compared to the congruent Stroop condition, for both age groups. Overall, the effect of increased cognitive load was greater for older adults than younger adults and was greatest in the portion of the sentence in which cognitive load was manipulated (during-Stroop), followed by the pre-Stroop segment. Sentence production accuracy was reduced for older adults in the incongruent condition.ConclusionsIncreased cognitive load involving response inhibition, selective attention, and working memory processes within a speech production task disrupted both the stability and timing with which speech was produced by both age groups. Older adults' speech motor performance may have been more affected due to age-related changes in cognitive and motoric functions that result in altered motor cognition.

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