scholarly journals Synthesis and evaluation of novel bone-targeting ibuprofen prodrug based on dendritic aspartic acid

2021 ◽  
Vol 78 (3) ◽  
pp. 329-337
Author(s):  
Yi Zhao ◽  
Ze Zhao ◽  
Yamin Cui ◽  
Changqing Chen ◽  
Changwei Xie ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Bone Targeting

scholarly journals Poly(Aspartic Acid) Functionalized Poly(ϵ-Caprolactone) Microspheres with Enhanced Hydroxyapatite Affinity as Bone Targeting Antibiotic Carriers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 885
Author(s):  
Stijn G. Rotman ◽  
Thomas F. Moriarty ◽  
Benjamin Nottelet ◽  
Dirk W. Grijpma ◽  
David Eglin ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Aspartic Acid ◽  
Bone Fractures ◽  
Poly Vinyl Alcohol ◽  
Water Emulsion ◽  
Bone Targeting ◽  
Efficient Delivery ◽  
Oil In Water Emulsion ◽  
Local Antibiotic

Bone infection is a feared complication for patients with surgically fixed bone fractures and local antibiotic delivery is important in prophylaxis and treatment of these infections. Recent studies indicated that Staphylococcus aureus can penetrate bone tissue through micron-sized canaliculi and evade systemic and currently available local antibiotic treatments. Targeting bacteria within the bone requires highly efficient delivery of antimicrobials to the infected bone tissue. In this work, a biodegradable microsphere carrier loaded with antibiotics and with specific affinity to bone mineral was developed. Two widely used antibiotics, i.e., Gentamicin-dioctyl sulfosuccinate (GM-AOT) and Ciprofloxacin (CF) were embedded in poly(ϵ-caprolactone) (PCL) microspheres fabricated by oil-in-water emulsion techniques with carboxylated poly(vinyl alcohol) (cPVA) as surfactant. The carboxylic acid groups present at the Poly(ϵ-caprolactone)/cPVA (PCL-cPVA) microsphere surface were functionalized with aspartic acid oligomers (ASP) granting bone targeting properties. We report on cPVA synthesis, microsphere formulation, and antibiotic loading of PCL/cPVA-ASP microspheres. Antibiotic loaded PCL/cPVA-ASP microspheres show sustained release of its antibiotic load and can inhibit bacterial growth in vitro for up to 6 days. PCL/cPVA-ASP microspheres show enhanced affinity to mineralized substrates compared to non-functionalized PCL/cPVA microspheres. These findings support further development of these bone targeting antibiotic carriers for potential treatment of persistent bone infections.

Poly aspartic acid peptide-linked PLGA based nanoscale particles: Potential for bone-targeting drug delivery applications

2014 ◽  
Vol 475 (1-2) ◽  
pp. 547-557 ◽  
Author(s):  
Tao Jiang ◽  
Xiaohua Yu ◽  
Erica J. Carbone ◽  
Clarke Nelson ◽  
Ho Man Kan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aspartic Acid ◽  
Nanoscale Particles ◽  
Bone Targeting ◽  
Drug Delivery Applications

Osteotropic Nanoscale Drug Delivery System via a Single Aspartic Acid as the Bone-Targeting Moiety

2017 ◽  
Vol 17 (3) ◽  
pp. 1747-1752 ◽  
Author(s):  
Erica J Carbone ◽  
Komal Rajpura ◽  
Tao Jiang ◽  
Ho-Man Kan ◽  
Xiaohua Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Aspartic Acid ◽  
Delivery System ◽  
Bone Targeting

Aspartic acid-based modified PLGA–PEG nanoparticles for bone targeting: In vitro and in vivo evaluation

2014 ◽  
Vol 10 (11) ◽  
pp. 4583-4596 ◽  
Author(s):  
Yin-Chih Fu ◽  
Tzu-Fun Fu ◽  
Hung-Jen Wang ◽  
Che-Wei Lin ◽  
Gang-Hui Lee ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
In Vivo Evaluation ◽  
Bone Targeting

Development of PEGylated aspartic acid-modified liposome as a bone-targeting carrier for the delivery of paclitaxel and treatment of bone metastasis

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 74-85 ◽  
Author(s):  
Shugo Yamashita ◽  
Hidemasa Katsumi ◽  
Nozomi Hibino ◽  
Yugo Isobe ◽  
Yumiko Yagi ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Aspartic Acid ◽  
Bone Targeting

Analysis of Aspartic Acid at Position 9 of the HLA-C Molecule in Patients with Psoriasis Vulgaris.

1996 ◽  
Vol 58 (6) ◽  
pp. 991-993
Author(s):  
Eishin MORITA ◽  
Susumu SHINODA ◽  
Eiichi GYOTOKU ◽  
Satoko HIHARA ◽  
Shoso YAMAMOTO
Keyword(s):  
Aspartic Acid ◽  
Psoriasis Vulgaris

Preparation, Characterization and Preliminary Trichomonacidal Effect of Poly Aspartic Acid-metronidazole Nanoprodrug*

2009 ◽  
Vol 36 (8) ◽  
pp. 1056-1063
Author(s):  
Xiao-Hong QI ◽  
Xi-Min CHEN ◽  
Zhen-Qing FENG ◽  
Xiao-Hong GUAN ◽  
Jun WU ◽  
...  
Keyword(s):  
Aspartic Acid
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