scholarly journals Development and validation of spectrofluorometric method for determination of pioglitazone HCL in marketed and non- marketed pharmaceutical tablet dosage forms

2020 ◽  
Vol 77 (5) ◽  
pp. 699-705
Author(s):  
Hamad Alyami ◽  
SAMER ABU- ALRUB ◽  
MATER MAHNASHI ◽  
ABDULLAH ALHARTHI
Keyword(s):  
Dosage Forms ◽  
Pharmaceutical Tablet ◽  
Spectrofluorometric Method ◽  
Development And Validation ◽  
Tablet Dosage

METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PIOGLITAZONE IN BULK SAMPLES AS WELL AS IN TABLET DOSAGE FORMS BY USING RP -HPL C

INDIAN DRUGS ◽  
2016 ◽  
Vol 53 (09) ◽  
pp. 42-46
Author(s):  
M Debnath ◽  
◽  
A. S. Kumar ◽  
V. D. S Ganta
Keyword(s):  
Method Development ◽  
Dosage Forms ◽  
Hplc Method ◽  
Uv Detector ◽  
Pharmaceutical Dosage Forms ◽  
Method Development And Validation ◽  
The Mean ◽  
Development And Validation ◽  
Tablet Dosage

A simple and precise RP‐HPLC method was developed and validated for the determination of pioglitazone hydrochloride in pharmaceutical dosage forms. Chromatography was carried out using Kromosil- C18 ODS column (250 x 4.6 mm; 5 μm), mixture of acetate buffer: methanol (40:60 v/v) as the mobile phase at a flow rate 1.0 mL/min. The analyte was monitored using UV detector at 254 nm. The retention time for pioglitazone HCl was 3.063 min. The proposed method was found linear in the concentration range of 20.0‐70.0 μg/ml with correlation coefficient of r2=0.9999. The developed method has been statistically validated and found simple and accurate. The mean recoveries obtained for pioglitazone HCl were in the range 99.20-101.59%. Due to its simplicity, rapidness, high precision and accuracy of the proposed method it may be used for determining pioglitazone HCl in bulk and dosage forms.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF PROCHLORPERAZINE MALEATE AND PYRIDOXINE HYDROCHLORIDE IN TABLET DOSAGE FORM BY UV USING MULTI-COMPONENT MODE OF ANALYSIS

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (03) ◽  
pp. 20-25
Author(s):  
G. B Bhagwat ◽  
◽  
S. P Wate ◽  
A. S. Mundhey
Keyword(s):  
Efficient Method ◽  
Dosage Form ◽  
Uv Spectroscopy ◽  
Dosage Forms ◽  
Simultaneous Estimation ◽  
Analysis Method ◽  
Pyridoxine Hydrochloride ◽  
Development And Validation ◽  
Tablet Dosage

Prochlorperazine maleate and pyridoxine hydrochloride in combination are available as tablet dosage forms in the ratio of 1:5. A simple, reproducible and efficient method for the simultaneous determination of prochlorperazine maleate and pyridoxine hydrochloride in tablet dosage form has been developed. The developed method is based on the simultaneous estimation by UV Spectroscopy, using multi-component mode of analysis. In this method 0.3M HCl was used as solvent. Wavelengths selected for estimation of prochlorperazine maleate and pyridoxine hydrochloride in multi-component mode of analysis method were 254.5 nm and 290.5 nm respectively. Both drugs obey Beer-Lambert’s law in concentration range of 1-5 µg/mL (prochlorperazine maleate) and 5-25 µg/mL (pyridoxine hydrochloride). The results of analysis have been validated statistically and by recovery studies.

Validated UV-Visible spectrometry using water as a solvent for determination of chloroquine in tablet samples

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Linear Dependence ◽  
Dosage Forms ◽  
Distilled Water ◽  
Pharmaceutical Tablet ◽  
Accuracy And Precision ◽  
Tablet Formulations ◽  
Uv Visible ◽  
Tablet Dosage ◽  
Excellent Accuracy

Methods reported including the official methods for determination ofchloroquine in tablet samples use carcinogenic organic solvents. In this study,UV-Vis spectrometry using water as a solvent was developed for determination ofchloroquine phosphate in pharmaceutical tablet dosage forms. The method wasvalidated according to the International Conference on Harmonization (ICH) andUSP guidelines. The absorbance of chloroquine phosphate in distilled water at max of 343 nm showed linear dependence on concentration in the range 10.88-30.56μg mL-1 with determination coefficient of 0.99972. Recovery results in the range98.79–101.20% and low coefficient of variation values for intra-day and interdayprecisions (0.37% and 0.76%, respectively) showed the accuracy andreproducibility of the method. The method was used for determination ofchloroquine phosphate in tablet formulations of different brands. Results in therange 100.63–103.52% of the labeled chloroquine phosphate in tabletformulations confirmed the applicability of the developed method for real sampleanalysis. Hence, the developed UV-Vis method using environmentally friendlywater as a solvent, with an excellent accuracy and precision showed that thedeveloped method can be a potential substituent for the official referencemethods.

scholarly journals Validated UV-Spectrophotometric Methods for Determination of Gemifloxacin Mesylate in Pharmaceutical Tablet Dosage Forms

2010 ◽  
Vol 7 (s1) ◽  
pp. S344-S348 ◽  
Author(s):  
R. Rote Ambadas ◽  
P. Pingle Sunita
Keyword(s):  
Wavelength Range ◽  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Pharmaceutical Tablet ◽  
Curve Method ◽  
Tablet Dosage ◽  
Simple Economic

Two simple, economic and accurate UV spectrophotometric methods have been developed for determination of gemifloxacin mesylate in pharmaceutical tablet formulation. The first UV-spectrophotometric method depends upon the measurement of absorption at the wavelength 263.8 nm. In second area under curve method the wavelength range for detection was selected from 268.5-258.5 nm. Beer’s law was obeyed in the range of 2 to 12 μgmL-1for both the methods. The proposed methods was validated statistically and applied successfully to determination of gemifloxacin mesylate in pharmaceutical formulation.

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