scholarly journals THE INFLUENCE OF PLASTICIZER IN NAIL LACQUER FORMULATIONS ON FLUCONAZOLE PERMEABILITY THROUGH THE BOVINE HOOF MEMBRANE

2020 ◽  
Vol 77 (1) ◽  
pp. 43-56
Author(s):  
Alisa Elezovic ◽  
Amar Elezović ◽  
Jasmina Hadziabdic
Keyword(s):  
Nail Lacquer ◽  
Bovine Hoof

scholarly journals Polishing the Therapy of Onychomycosis Induced by Candida spp.: Amphotericin B–Loaded Nail Lacquer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 784
Author(s):  
Aleph M. S. Souza ◽  
Renato C. A. Ribeiro ◽  
Gleyse K. L. O. Pinheiro ◽  
Francisco I. Pinheiro ◽  
Wógenes N. Oliveira ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Ex Vivo ◽  
Drug Loading ◽  
Drug Bioavailability ◽  
Candida Spp ◽  
Drying Time ◽  
Analytical Method Validation ◽  
Nail Lacquer ◽  
In Vitro Adhesion

Onychomycosis induced by Candida spp. has several limitations regarding its treatment. Nail lacquers display the potential to overcome these drawbacks by providing therapeutic compliance and increasing local drug bioavailability. Thus, this work aimed to produce a nail lacquer loaded with Amphotericin B (AmB) and evaluate its performance. The AmB-loaded nail lacquer was produced and preliminarily characterized. An AmB quantification method was developed. Stability, drug release, permeability and anti-Candida activity assays were conducted. The analytical method validation met the acceptance criteria. The drug loading efficiency was 100% (0.02 mg/g of total product), whereas the AmB stability was limited to ≅ 7 days (≅ 90% remaining). The nail lacquer displayed a drying time of 187 s, non-volatile content of around 20%w/w, water-resistance of approximately 2%w/w of weight loss and satisfactory in vitro adhesion. Moreover, the in vitro antifungal activity against different Candida spp. strains was confirmed. The AmB release and the ex vivo permeability studies revealed that AmB leaves the lacquer and permeates the nail matrix in 47.76 ± 0.07% over 24 h. In conclusion, AmB-loaded nail lacquer shows itself as a promising extemporaneous dosage form with remarkable anti-Candida activity related to onychomycosis.

scholarly journals Comparative clinical evaluation of efficacy and safety of a formulation containing ciclopirox 8% in the form of a therapeutic nail lacquer in two different posologies for the treatment of onychomycosis of the toes

2012 ◽  
Vol 87 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Sergio Schalka ◽  
Samanta Nunes ◽  
Antonio Gomes Neto
Keyword(s):  
Treatment Resistance ◽  
Comparative Trial ◽  
Trichophyton Mentagrophytes ◽  
Weekly Dose ◽  
Efficacy And Safety ◽  
Therapeutic Success ◽  
Group I ◽  
Nail Lacquer ◽  
Significant Difference ◽  
Treatment Objective

BACKGROUND: The use of topical antifungal agents in the treatment of onychomycosis is of great value in clinical practice as there are different limitations regarding the use of systemic treatment. OBJECTIVE: To evaluate the efficacy and safety of a nail lacquer formulation containing ciclopirox 8% in two different posologies: the traditional regimen (3/2/1) and a regimen of weekly use. METHODS: A blind, randomized, comparative trial which included 41 patients divided into 02 groups, with Group I using the nail lacquer once weekly and Group II using the traditional regimen (3/2/1). Both groups applied the medication for 06 months. RESULTS: The species most frequently found in groups I and II were Trichophyton rubrum (55% and 61.9%) and Trichophyton mentagrophytes (30% and 19%). There was a tendency to a higher level of treatment resistance by T. mentagrophytes infection in both groups, without any predilection for sex, age, proportion of the nail affected at the beginning of the study, duration of the clinical disease and quantity of nails affected per person. Both groups had significant levels of mycological cure, clinical response and therapeutic success and there was no statistically significant difference between groups I and II (p >0.05). CONCLUSION: The nail lacquer containing ciclopirox 8% was equally effective at a weekly dose when compared to the traditional dosing (3/2/1), allowing a more comfortable regimen.

Case of infantile onychomycosis successfully cured by 5% amorolfine nail lacquer

2014 ◽  
Vol 50 (11) ◽  
pp. 933-934 ◽  
Author(s):  
Shuang Chen ◽  
Yu‐Ping Ran ◽  
Ya‐Lin Dai ◽  
Jebina Lama ◽  
Wen‐Ying Hu
Keyword(s):  
Nail Lacquer

scholarly journals TRANSUNGUAL PERMEATION OF THE VORICONAZOLE NAIL LACQUER AGAINST TRICHOPHYTON RUBRUM

2012 ◽  
Vol 2 (1) ◽  
Author(s):  
Amruta Ashok Tandel ◽  
Surendra Agrawal ◽  
Shaijesh Shirish Wankhede
Keyword(s):  
Trichophyton Rubrum ◽  
Nail Lacquer
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