scholarly journals Low dose high energy x-ray in-line phase sensitive imaging prototype: Investigation of optimal geometric conditions and design parameters

2015 ◽  
Vol 23 (6) ◽  
pp. 667-682 ◽  
Author(s):  
Muhammad U. Ghani ◽  
Aimin Yan ◽  
Molly D. Wong ◽  
Yuhua Li ◽  
Liqiang Ren ◽  
...  
Keyword(s):  
Low Dose ◽  
High Energy ◽  
Design Parameters ◽  
X Ray ◽  
Geometric Conditions ◽  
Phase Sensitive

Development and Pre‐Clinical Evaluation of a Patient‐Specific High Energy X‐ray Phase Sensitive Breast Tomosynthesis System

2021 ◽  
Author(s):  
Muhammad U. Ghani ◽  
Xizeng Wu ◽  
Laurie L. Fajardo ◽  
Zhengxue Jing ◽  
Molly D. Wong ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
High Energy ◽  
Patient Specific ◽  
Breast Tomosynthesis ◽  
X Ray ◽  
Phase Sensitive

Evaluation and comparison of a CdTe based photon counting detector with an energy integrating detector for X-ray phase sensitive imaging of breast cancer

2021 ◽  
pp. 1-13
Author(s):  
Muhammad U. Ghani ◽  
Farid H. Omoumi ◽  
Xizeng Wu ◽  
Laurie L. Fajardo ◽  
Bin Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Spatial Resolution ◽  
Standard Dose ◽  
Photon Counting ◽  
High Energy ◽  
Edge Enhancement ◽  
X Ray ◽  
Photon Counting Detector ◽  
Phase Sensitive ◽  
Observer Studies

PURPOSE: To compare imaging performance of a cadmium telluride (CdTe) based photon counting detector (PCD) with a CMOS based energy integrating detector (EID) for potential phase sensitive imaging of breast cancer. METHODS: A high energy inline phase sensitive imaging prototype consisting of a microfocus X-ray source with geometric magnification of 2 was employed. The pixel pitch of the PCD was 55μm, while 50μm for EID. The spatial resolution was quantitatively and qualitatively assessed through modulation transfer function (MTF) and bar pattern images. The edge enhancement visibility was assessed by measuring edge enhancement index (EEI) using the acrylic edge acquired images. A contrast detail (CD) phantom was utilized to compare detectability of simulated tumors, while an American College of Radiology (ACR) accredited phantom for mammography was used to compare detection of simulated calcification clusters. A custom-built phantom was employed to compare detection of fibrous structures. The PCD images were acquired at equal, and 30% less mean glandular dose (MGD) levels as of EID images. Observer studies along with contrast to noise ratio (CNR) and signal to noise ratio (SNR) analyses were performed for comparison of two detection systems. RESULTS: MTF curves and bar pattern images revealed an improvement of about 40% in the cutoff resolution with the PCD. The excellent spatial resolution offered by PCD system complemented superior detection of the diffraction fringes at boundaries of the acrylic edge and resulted in an EEI value of 3.64 as compared to 1.44 produced with EID image. At MGD levels (standard dose), observer studies along with CNR and SNR analyses revealed a substantial improvement of PCD acquired images in detection of simulated tumors, calcification clusters, and fibrous structures. At 30% less MGD, PCD images preserved image quality to yield equivalent (slightly better) detection as compared to the standard dose EID images. CONCLUSION: CdTe-based PCDs are technically feasible to image breast abnormalities (low/high contrast structures) at low radiation dose levels using the high energy inline phase sensitive imaging technique.

scholarly journals A method for high-energy, low-dose mammography using edge illumination x-ray phase-contrast imaging

2016 ◽  
Vol 61 (24) ◽  
pp. 8750-8761 ◽  
Author(s):  
Paul C Diemoz ◽  
Alberto Bravin ◽  
Anikó Sztrókay-Gaul ◽  
Marie Ruat ◽  
Susanne Grandl ◽  
...  
Keyword(s):  
Phase Contrast ◽  
Low Dose ◽  
High Energy ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
X Ray

scholarly journals Synchrotron high energy X-ray methods coupled to phase sensitive analysis to characterize aging of solid catalysts with enhanced sensitivity

2013 ◽  
Vol 15 (22) ◽  
pp. 8629 ◽  
Author(s):  
Davide Ferri ◽  
Mark A. Newton ◽  
Marco Di Michiel ◽  
Songhak Yoon ◽  
Gian Luca Chiarello ◽  
...  
Keyword(s):  
High Energy ◽  
Sensitive Analysis ◽  
X Ray ◽  
Solid Catalysts ◽  
Enhanced Sensitivity ◽  
Phase Sensitive ◽  
Ray Methods

scholarly journals Low-dose exposure energy-resolved X-ray computed tomography using a contrast agent with a high-energy K-edge

2013 ◽  
Vol 51 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Yoshiki Yamashita ◽  
Kazunari Shima ◽  
Ikuo Kanno ◽  
Masahiko Ohtaka ◽  
Makoto Hashimoto ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Low Dose ◽  
High Energy ◽  
X Ray ◽  
X Ray Computed ◽  
Exposure Energy

scholarly journals High Energy Resolution Hyperspectral X-Ray Imaging for Low-Dose Contrast-Enhanced Digital Mammography

2017 ◽  
Vol 36 (9) ◽  
pp. 1784-1795 ◽  
Author(s):  
Silvia Pani ◽  
Sarene C. Saifuddin ◽  
Filipa I.M. Ferreira ◽  
Nicholas Henthorn ◽  
Paul Seller ◽  
...  
Keyword(s):  
Energy Resolution ◽  
Digital Mammography ◽  
Low Dose ◽  
High Energy ◽  
High Energy Resolution ◽  
X Ray ◽  
X Ray Imaging ◽  
Contrast Enhanced

scholarly journals Low-dose X-ray structure analysis of cytochrome c oxidase utilizing high-energy X-rays

2019 ◽  
Vol 26 (4) ◽  
pp. 912-921 ◽  
Author(s):  
Go Ueno ◽  
Atsuhiro Shimada ◽  
Eiki Yamashita ◽  
Kazuya Hasegawa ◽  
Takashi Kumasaka ◽  
...  
Keyword(s):  
Radiation Damage ◽  
Low Dose ◽  
High Energy ◽  
Array Detector ◽  
X Rays ◽  
Data Set ◽  
X Ray ◽  
Ligand Structure ◽  
Biology I ◽  
On Line

To investigate the effect of high-energy X-rays on site-specific radiation-damage, low-dose diffraction data were collected from radiation-sensitive crystals of the metal enzyme cytochrome c oxidase. Data were collected at the Structural Biology I beamline (BL41XU) at SPring-8, using 30 keV X-rays and a highly sensitive pixel array detector equipped with a cadmium telluride sensor. The experimental setup of continuous sample translation using multiple crystals allowed the average diffraction weighted dose per data set to be reduced to 58 kGy, and the resulting data revealed a ligand structure featuring an identical bond length to that in the damage-free structure determined using an X-ray free-electron laser. However, precise analysis of the residual density around the ligand structure refined with the synchrotron data showed the possibility of a small level of specific damage, which might have resulted from the accumulated dose of 58 kGy per data set. Further investigation of the photon-energy dependence of specific damage, as assessed by variations in UV-vis absorption spectra, was conducted using an on-line spectrometer at various energies ranging from 10 to 30 keV. No evidence was found for specific radiation damage being energy dependent.

scholarly journals Low-dose X-ray structure analysis of cytochrome oxidase utilizing high-energy X-rays

2017 ◽  
Vol 73 (a2) ◽  
pp. C1027-C1027
Author(s):  
Go Ueno ◽  
Atsuhiro Shimada ◽  
Eiki Yamashita ◽  
Kazuya Hasegawa ◽  
Takashi Kumasaka ◽  
...  
Keyword(s):  
Cytochrome Oxidase ◽  
Structure Analysis ◽  
Low Dose ◽  
High Energy ◽  
X Rays ◽  
X Ray

Monte Carlo simulations for XIDer, a novel digital integration X-ray detector for the next generation of synchrotron radiation sources

2022 ◽  
Vol 17 (01) ◽  
pp. C01037
Author(s):  
M. Collonge ◽  
P. Busca ◽  
P. Fajardo ◽  
M. Williams
Keyword(s):  
Monte Carlo ◽  
Synchrotron Radiation ◽  
High Energy ◽  
Design Parameters ◽  
Next Generation ◽  
X Ray ◽  
Digital Integration ◽  
Radiation Sources ◽  
Simulation Results ◽  
Readout Scheme

Abstract This work presents the first simulation results of the incremental digital integration readout, a charge-integrating front-end scheme with in-pixel digitisation and accumulation. This novel readout concept is at the core of the XIDer (X-ray Integrating Detector) project, which aims to design 2D pixelated X-ray detectors optimised for high energy scattering and diffraction applications for the next generation of synchrotron radiation sources such as the ESRF Extremely Brilliant Source (EBS). The digital integration readout and the XIDer detector open the possibilities for high-duty-cycle operation under very high photon flux, fast frame-rate and high dynamic range with single-photon sensitivity in the 30–100 keV energy range. The readout method allows for noise-free effective X-ray detection. The digital integration concept is currently under investigation to evaluate the impact of main critical design parameters to identify the strengths and weaknesses of the readout scheme and consequently to propose refinements in the final implementation. Simulations have been performed with a dedicated Monte Carlo simulation tool, X-DECIMO, a modular Python package designed to recreate the complete detection chain of X-ray detectors for synchrotron radiation experiments. Losses and non-linearities of the readout scheme are simulated and quantified. In addition to presenting simulation results for this novel readout scheme, this work underlines the potential of the approach and some of its limitations.

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