Influence of different fixation methods on the fracture force of osteoporotic human lumbar vertebral bodies in the generation of vertebral compression fractures

2020 ◽  
pp. 1-6
Author(s):  
Michael Kraxenberger ◽  
Manuel Dreu ◽  
Patrick Sadoghi ◽  
Christof Birkenmaier ◽  
Wolfram Teske ◽  
...  
Keyword(s):  
Focus Groups ◽  
Compression Fracture ◽  
Vertebral Compression Fractures ◽  
Compression Tests ◽  
Fracture Force ◽  
Mean Values ◽  
Fixation Methods ◽  
Significant Difference ◽  
Fresh Frozen ◽  
Vertebral Bodies

BACKGROUND: The use of fresh-frozen (FF) specimens represents the gold standard for biomechanical investigations. Since FF specimens are often difficult to obtain, chemical-fixed specimens (formalin (FA), Thiel (TH)) are also used. OBJECTIVE: Since fixation methods can alter the mechanical properties of bone tissue, the purpose of this study was to examine their influence on the fracture force of lumbar vertebral bodies (VB). METHODS: First the VB were subdivided into three focus groups: FF, TH, and FA. After removing the soft tissue and the processus transverses of all VB, the endplates were planned with a thin layer of epoxy resin, in order to apply a constant strain to the surface and sub-surface. The VB were subjected to axial compression tests in order to determine fracture force. Lastly a standardized compression fracture was generated. RESULTS: The mean values of the fracture force of the focus groups were 4529.5 N (FF), 3211.3N (TH) and 2947.9N (FA). Consequently a significant difference between the FF and the other two groups could be demonstrated (p< 0.05). CONCLUSION: The preliminary tests showed that the fraction force of fresh-frozen VB were significantly higher than TH/FA-fixed VB. Therefore, these fixation methods could potentially have an influence on the biomechanical properties of VB. This leads to the assumption that if load-to-failure tests are performed, it is probably recommended to use fresh-frozen specimens.

scholarly journals Unilateral curved versus bipedicular vertebroplasty in the treatment of osteoporotic vertebral compression fractures

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Rui Zhong ◽  
Jianheng Liu ◽  
Runsheng Wang ◽  
Yihao Liu ◽  
Binbin Chen ◽  
...  
Keyword(s):  
Compression Fracture ◽  
Operation Time ◽  
Cement Leakage ◽  
Leakage Rate ◽  
Vertebral Compression Fractures ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Significant Difference ◽  
Vas Scores ◽  
Postoperative Improvement

Abstract Background Vertebral compression fracture is one of the most common complications of osteoporosis. In this study an unilateral curved vertebroplasty device was developed, and the safety, effectiveness, and surgical parameters of curved vertebroplasty (CVP) in the treatment of painful osteoporotic vertebral compression fractures was investigated and compared with traditional bipedicular vertebroplasty (BVP). Methods We investigated 104 vertebral augmentation procedures performed over 36 months. CVP and BVP procedures were compared for baseline clinical variables, pain relief (Visual Analog Scale, VAS), disability improvement (Oswestry Disability Index, ODI), operation time, number of fluoroscopic images, volume of cement per level, and cement leakage rate for each level treated. Complications and refracture incidence were also recorded in the two groups. Results The VAS and ODI in both group had no significant difference preoperative (P > 0.05), and a significant postoperative improvement in the VAS scores and ODI was found in both group (P < 0.001). However, the CVP group had significantly lower operation time, number of fluoroscopic images, and cement leakage rate per level than the BVP group (P < 0.05); however, the volumes of cement per level were similar in the two groups (P > 0.05). Neither group had any serious complications. Five and two patients in the BVP group developed refractures at non-adjacent and adjacent levels, respectively, with one patient developing refractures twice; however, none of the patients in the CVP group developed refractures at any level. Conclusions Our findings revealed that both CVP and BVP were safe and effective treatments for osteoporotic vertebral compression fractures, and CVP entails a shorter operation time, less exposure to fluoroscopy, and lower rate of cement leakage.

scholarly journals Percutaneous Vertebroplasty: Efficacy of Unipedicular Vertebroplasty as Compared to Bipedicular Vertebroplasty

2022 ◽  
Author(s):  
Mahendra Kumar Dwivedi ◽  
Vikrant Bhende ◽  
Dnyaneshwar Narayanrao Panchbhaiyye ◽  
Madhura Vijay Bayaskar
Keyword(s):  
Vertebral Compression Fracture ◽  
Percutaneous Vertebroplasty ◽  
Compression Fracture ◽  
P Value ◽  
Significant Difference ◽  
Insignificant Difference ◽  
Vas Scores ◽  
Vertebral Bodies ◽  
The Mean ◽  
Standard Techniques

Abstract Introduction Percutaneous vertebroplasty has been used for treatment of intractable painful fractures of vertebral bodies. With the help of refined procedures and standard techniques, the interventional radiologist can now offer help to orthopedics and neurosurgeons in these cases, which include treatment of vertebral compression fracture. Vertebroplasty is aimed at reducing the pain induced by collapse. Vertebroplasty is the standard mode of treatment for vertebral collapse, and in our study, bipedicular vertebroplasty was compared with unipedicular approach as bipedicular vertebroplasty is the routinely used approach. Aim To compare efficacy of unipedicular percutaneous vertebroplasty with that of bipedicular percutaneous vertebroplasty. Material and Methods A total of 52 vertebroplasties were done over a period of 2 years. Out of 52 patients, 28 patients underwent unipedicular vertebroplasty and 24 patients underwent bipedicular vertebroplasty. Visual analogue scale (VAS) scores were used to assess the pain prior to vertebroplasty and after vertebroplasty. Efficacy of the two procedures were assessed by comparing VAS scores. Results There was no statistically significant difference observed in the preprocedure and postprocedure VAS scores (p-value < 0.0001, < 0.0001, respectively). The mean procedure time was lesser in unipedicular vertebroplasty (41.9 ± 3.90) than bipedicular vertebroplasty (54.5 ± 3.4). Conclusion Unipedicular vertebroplasty is as effective as bipedicular vertebroplasty, as there is insignificant difference in postprocedure VAS scores between the unipedicular and bipedicular vertebroplasty.

PHYSICAL PROPERTIES OF EGGSHELLS: A COMPARISON OF THE PUNCTURE AND COMPRESSION TESTS FOR ESTIMATING SHELL STRENGTH

1977 ◽  
Vol 57 (2) ◽  
pp. 329-338 ◽  
Author(s):  
J. R. HUNT ◽  
PETER W. VOISEY ◽  
B. K. THOMPSON
Keyword(s):  
Shell Thickness ◽  
Shear Fracture ◽  
Compression Fracture ◽  
Compression Tests ◽  
Fracture Force ◽  
Static Compression ◽  
Fracture Properties ◽  
Puncture Force ◽  
Increase In Accuracy ◽  
Quasi Static Compression

Quasi-static compression and puncture methods of measuring eggshell strength were compared by testing consecutive eggs from each of 89 birds alternately until eight eggs per bird were tested by each method. Results indicated that the tensile and shear fracture properties of the shell material were linearly related to each other, and to shell thickness and specific gravity. Both puncture force and compression fracture force were significantly different on a between-hen basis even when adjusted for shell thickness. Puncture force was more closely related to shell thickness on a between-egg basis than was compression fracture force. Puncture force was not related to shell thickness on a within-egg basis. The increase in accuracy gained from repeated puncture measurements on a within-egg basis was discussed.

Vertebral Compression Fractures in Patients with Chronic Lymphocytic Leukemia: Incidence and Risk Factors

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4586-4586
Author(s):  
Amrita Desai ◽  
Benjamin Kuritzky ◽  
Jorge J Castillo ◽  
Adam J. Olszewski
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Bone Density ◽  
Watchful Waiting ◽  
Compression Fracture ◽  
Lymphocytic Leukemia ◽  
Vertebral Compression Fractures ◽  
Radiographic Findings ◽  
Compression Fractures ◽  
Significant Difference

Abstract Abstract 4586 Introduction: Patients with chronic lymphocytic leukemia (CLL) have infiltrative bone marrow changes in vertebral bodies on radiographic studies. Whether CLL is associated with an increased risk of compression fracture and/or osteoporosis in correlation with the burden or duration of the disease has not been studied. For this purpose, we performed a retrospective case-control study. Methods: After obtaining Institutional Review Board approval, we reviewed the records of CLL patients managed in our centers with watchful waiting from diagnosis until treatment. Data on demographic, clinical and laboratory variables, radiographic findings and treatment were collected. Presence of osteoporosis and compression fractures was ascertained from physician evaluation notes, bone densitometry studies and/or computed tomography (CT) scan results prior to initiation of chemotherapy. CLL cases were matched by age, sex and body mass index (BMI) at 1:2 ratio to healthy controls derived from a local Family Practice database. Cox regression models were used for the evaluation of hazard ratios (HR) and 95% confidence intervals (CI) for factors associated with compression fractures in patients with CLL undergoing a watchful waiting approach. Results: Among 96 CLL cases included in the analysis there were 48% women, 10% current and 34% former smokers. The median age was 71 years (range, 44–99), median BMI 26 (18–50) and median follow up time 2.9 years (0–22, with the last follow up between 2003 and 2012). The median absolute lymphocyte count (ALC) was 40,850/mm3 (5,700–969,000/mm3), mean hemoglobin 12.4 g/dL (+/− 2.2 g/dL), lactate dehydrogenase 202 IU/L (+/− 95 IU/L), 25-OH-vitamin D 30.7 ng/mL (+/− 12.3 ng/mL). Staging CT scans were available in 68% of cases, but bone density scans only in 13% (2% men, 24% women). Chemotherapy was started in 41% of patients after a median time of 2.4 years from diagnosis. Osteoporosis and osteopenia were each recorded in 12% of patients while a vertebral compression fracture was present in 7%. With marked differences in the availability of evaluation tests (e.g. bone density, p<0.001) and length of period of observation between CLL cases and matched controls, there was no significant difference in the odds of compression fracture (odds ratio 1.0, 95%CI 0.32–2.84, p=1.0). In the time-to-event analysis, the rate of compression fracture occurrence was 1.7% per year (95%CI 0.8–3.6%). Compression fractures in CLL patients were associated with underlying osteoporosis or osteopenia (HR 12.8, 95%CI 1.5–109, p=0.004), ALC over 100,000/mm3 (HR 5.1, 95%CI 1.1–23.7, p=0.04) and anemia, defined as hemoglobin less than 12 g/dL (HR 8.9, 95%CI 1.1–74, P=0.01, Fig.1). Conclusions: CLL patients managed with watchful waiting may be at risk of vertebral compression fractures proportional to the burden of disease. Further prospective research may delineate potential role for screening for osteoporosis and prevention of osteoporosis and vertebral fractures in this population. Disclosures: No relevant conflicts of interest to declare.

Role of Fracture Liaison Service Program in Reducing Refracture Rate in the Elderly Osteoporotic Trauma Patients Presenting With Vertebral Compression Fracture: A Six-Year Study

2021 ◽  
pp. 000313482110475
Author(s):  
Noah Kelm ◽  
Tarik Wasfie ◽  
Max Volk ◽  
Zach Walker ◽  
Stephanija Galovska ◽  
...  
Keyword(s):  
Compression Fracture ◽  
The Elderly ◽  
Fracture Liaison Service ◽  
Vertebral Compression Fractures ◽  
Trauma Patients ◽  
Vertebral Augmentation ◽  
Dxa Scan ◽  
Significant Difference ◽  
Frax Score ◽  
Fracture Liaison

Introduction As the elderly population of the United States and the world increases, so does the incidence of osteoporotic fragility fractures from a fall or minor injury. This results in a large cost to the health care system. This cost is further increased as more than 50% of individuals will have refractures within the first year. In order to reduce the refracture rate in such patients, we enrolled our elderly trauma patients with vertebral compression fractures and vertebral augmentation in a Fracture Liaison Service (FLS) clinic for two years and reevaluated their refracture rate. Method This is a retrospective analysis of 720 patients. 142 patients (Group A) were seen between 2012 and 2014 before establishing the FLS program and 578 patients (Group B) were seen between 2015 and 2020 after implementation of the FLS program. The patients enrolled in the FLS program were followed for two years after sustaining a vertebral compression fracture. The data collected included age, sex, serum calcium and vitamin D levels, dual energy X-ray absorptiometry (DXA) scan, 10-year fracture risk (FRAX) score, pressure measurements in PSI taken during vertebral augmentation, as well as the refracture rate. The data collected were analyzed and compared between the two groups using the Student’s t-test and chi-square test. Results There was significant reduction in the refracture rate of pre-FLS vs post-FLS vertebral, as well as other fractures in the FLS group (pre-FLS: 48.9% vs post-FLS: 37.0%; P = .01). There was no significant difference between groups A and B in regard to the mean serum level of calcium (9.44 mg/dL vs 9.53 mg/dL), vitamin D level (35.04 ng/mL vs 41.39 ng/mL), DXA scan for spine (−.52 vs −.76) and for femur (−1.77 vs −1.52), and 10-year refracture risk for osteoporotic major fracture (FRAX score-mean: 22.6% vs 19.2%) and for hip fracture (9.18% vs 7.53%). There was a significant difference in the mean age between the groups (79.5 vs 73.5 years; P = .01). Of those who underwent vertebral augmentation, 235 had Pressure Scale Index (PSI) measurements taken. There was a trend in increasing refracture rate when PSI ≤199 compared with those who had PSI ≥200, although statistical significance was not met (33.9% vs 27.0%, P = .21). Conclusion A Fracture Liaison Service program will improve the bone health of geriatric osteoporotic patients presenting to the trauma service with vertebral compression fractures and thus reduces the subsequent refracture rate. Further study is needed to evaluate the best PSI used to impact reduction in refracture rate.

scholarly journals Prophylactic Percutaneous Kyphoplasty Treatment for Nonfractured Vertebral Bodies in Thoracolumbar for Osteoporotic Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Fei Lei ◽  
Wen He ◽  
Xinggui Tian ◽  
Zhongyang Li ◽  
Lipeng Zheng ◽  
...  
Keyword(s):  
Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Percutaneous Kyphoplasty ◽  
Significant Difference ◽  
Thoracolumbar Region ◽  
Vas Scores ◽  
Vertebral Bodies ◽  
The Mean ◽  
One Year

Purpose. The occurrence of new vertebral compression fractures (VCFs) is a common complication after percutaneous kyphoplasty (PKP). Secondary VCFs after PKP occur predominantly in the thoracolumbar segment (T11 to L2). Prophylactic injections of cement into vertebral bodies in order to reduce new VCFs have rarely been reported. The main purpose of this study was to investigate whether prophylactically injecting cement into a nonfractured vertebral body at the thoracolumbar level (T11-L2) could reduce the occurrence of new VCFs. Methods. From July 2011 to July 2018, PKP was performed in 86 consecutive patients with osteoporotic vertebral compression fractures (OVCFs) in the thoracolumbar region (T11-L2). All patients selected underwent PKP because of existing OVCFs (nonprophylactic group). Additionally, 78 consecutive patients with fractured vertebrae in the thoracolumbar region (T11-L2) with OVCFs underwent PKP and received prophylactic injections of cement into their nonfractured vertebrae in the thoracolumbar region (T11-L2) (prophylactic group). The visual analog scale (VAS) scores and incidence of new VCFs after PKP were compared between the two groups. Results. The mean VAS scores improved from 8.00±0.79 preoperatively to 1.62±0.56 at the last follow-up in the nonprophylactic group and improved from 8.17±0.84 to 1.76±0.34 in the prophylactic group (P>0.05). In the nonprophylactic group, 21 of 86 patients (24.4%) developed new VCFs within one year after PKP, of whom 15 patients (71.4%) developed VCFs within 3 months. In the prophylactic group, 8 of 78 patients (10.3%) developed new VCFs within one year, and 6 of these 8 patients (75%) developed new VCFs within 3 months. The incidence of new VCFs was significantly higher in the nonprophylactic group than that in the prophylactic group at one year (P=0.018), but there were no statistically significant differences at three months (P=0.847). Conclusions. Prophylactic injections of cement into nonfractured (T11-L2) vertebral bodies reduced the incidence of secondary VCFs after PKP in patients with OVCFs, but there was no significant difference in local back pain (VAS) scores between the two groups.

scholarly journals Risk Factors of New Vertebral Compression Fracture After Percutaneous Kyphoplasty or Vertebroplasty: A Retrospective Study of 752 Patients

2021 ◽  
Author(s):  
Bo-bo Zhang ◽  
Zhong-wei Song ◽  
Ying Wang ◽  
Zhi-wei Ren ◽  
Wei-zhou Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Univariate Analysis ◽  
Compression Fracture ◽  
Osteoporosis Treatment ◽  
Vertebral Compression Fractures ◽  
Height Loss ◽  
Mineral Density ◽  
Compression Fractures ◽  
Factors Associated ◽  
Significant Difference

Abstract Summary Irregularly postoperative anti-osteoporosis treatment (AOT), number of treated vertebrae (NTV) ≥ 2, bone mineral density (BMD) ≤－3.0 SDs, body mass index (BMI) <18.5kg/m2 or BMI ≥ 24kg/m2, vertebral height loss ratio (VHLR)＞20% were strong risk factors associated with new vertebral compression fractures (NVCF) after percutaneous vertebroplasty or kyphoplasty (PVP/PKP) in patients with osteoporotic vertebral compression fractures (OVCF). There was no difference between NVCF occurred adjacent or remote after PKP/PVP intervention.Introduction NVCF have been connected to PVP/PKP surgery for patients with VCF. There are some debates about whether new vertebral body fractures are simply a result of the natural progression of osteoporosis or whether they should be regarded as a consequence of augmentation. We tried to investigate and identify the risk factors which may be relevant to NVCF after PVP/PKP surgery in OVCF patients.Methods The authors retrospectively analyzed the occurrence of NVCF in 752 patients treated with PVP or PKP for OVCF. Possible risk factors, such as age, gender, refracture time (RT), AOT, NTV, BMD, BMI, and VHLR, were assessed.All methods are carried out in accordance with relevant guidelines and regulations.Results Significant differences (P<0.05) were found between the NVCF and control groups with regard to AOT, number of treated vertebrae, BMD, BMI, and VHLR by univariate analysis. And irregularly AOT, NTV ≥ 2, BMD ≤－3.0 SDs, BMI < 18.5 kg/m2 or BMI ≥ 24kg/m2, VHLR＞20% were found to be the significant factors in multivariate analysis. To evaluate a direct and more precise effect of the procedures on untreated vertebrae, the NVCF group was subdivided into adjacent and remote fracture groups. All of factors have no significant difference between two subgroups.Conclusion In the current study, the incidence of NVCF after PVP/PKP is 9.58%. Irregularly AOT, NTV ≥ 2, BMD ≤－3.0 SDs, BMI <18.5kg/m2 or BMI ≥ 24kg/m2, VHLR＞20% were strong risk factors associated with NVCF after PVP/PKP in patients with OVCF. There was no difference between NVCF occurred adjacent or remote after PKP/PVP intervention and that might be the result of the osteoporosis itself. All of those should be addressed during preoperative communication and postoperative management.

scholarly journals Ultrasound-guided thoracic paravertebral block for percutaneous kyphoplasty: A prospective non-randomized comparative study

2020 ◽  
Author(s):  
Chengxuan TANG ◽  
Haijie XIA ◽  
Xiaojun TANG ◽  
Minghai DAI ◽  
Maoxiu PENG ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Compression Fracture ◽  
Operation Time ◽  
Paravertebral Block ◽  
Vertebral Compression Fractures ◽  
Ultrasound Guided ◽  
Local Infiltration ◽  
Thoracic Paravertebral Block ◽  
Percutaneous Kyphoplasty ◽  
Significant Difference

Abstract Introduction Kyphoplasty for osteoporotic vertebral compression fractures was short but painful. The purpose of the current study was to investigate the effects and safety of ultrasound-guided thoracic paravertebral block in patients undergoing percutaneous kyphoplasty (PKP). Methods A prospective study of 195 patients with thoracic compression fracture undergoing PKP was conducted. The patients were non-randomly assigned to receive an ultrasound-guided thoracic paravertebral block (Group P, n=96) and local infiltration anesthesia (Group L, n=99), and were compared along with intraoperative parameters and anesthetic effects. Visual analog scale (VAS) of pain, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured at pre-anesthesia (T0), post-anesthesia (T1), trocar insertion (T2), balloon dilatation (T3), cement injection (T4) and post-operation (T5). Results The anesthesia time was significantly longer in group P than in group L. There were no significant differences in the epidemiological data, operation time, blood loss, hospitalization time complications and costs between the two groups. The additional analgesics rate was significantly lower in group P than in group L. The investigators’ satisfaction scores, patients’ anesthesia satisfaction scores and intention rate of re-administration anesthesia were significantly higher in group P than in group L. Intraoperative VAS score (T1-T4) was significantly lower in group P than in group L. There was no significant difference in VAS scores (T0 and T5), SBP, DBP and HR between these two groups. Conclusion Ultrasound - guided thoracic paravertebral block achieved more effective analgesia in comparison to local infiltration groups in patients undergoing percutaneous kyphoplasty.

scholarly journals Biomechanical Results of Percutaneous Calcaneal Osteotomy using Two Different Osteotomy Designs

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0023
Author(s):  
Natalia Gutteck
Keyword(s):  
Clinical Practice ◽  
Bone Density ◽  
Failure Rate ◽  
Moderate Correlation ◽  
Compression Screw ◽  
Mean Values ◽  
Significant Difference ◽  
Secondary Dislocation ◽  
Fresh Frozen ◽  
Calcaneal Tuberosity

Category: Hindfoot Introduction/Purpose: Percutaneous osteotomy of calcaneus has been proposed to reduce the complication rate and became more and more popular. The bone cut can be performed as a straight or chevron-like (V) osteotomy using a Shannon burr. Comparative studies of straight or V- osteotomy as like as one or two screws in percutaneous calcaneal osteotomies are missing in the literature Methods: The straight osteotomy (9 fresh-frozen specimens) and V- osteotomy (9fresh frozen specimens) was performed and the calcaneal tuberosity was moved 10 mm medially and slightly rotated. One 6,5 mm cancellous compression screw was used for osteosynthesis. Specimens were preconditioned with 100N over 100 cycles. The force was increased after every 100N by 100N from 200 to 500N. This was followed by cyclic loading with 600N for 500 cycles. Results: Despite the higher mean values of the group with V osteotomy, no significant difference was registered between the two groups regarding the stiffness at all force levels. A significant higher failure rate was observed in the group with straight osteotomy. Conclusion: The moderate correlation of bone density and stiffness in the V-group, and significantly lower failure rate with no secondary dislocation in fluoroscopy indicates the superiority of the V-osteotomy in the present study. Whether the demonstrated advantages can be reflected in clinical practice should be investigated in further studies.

scholarly journals Efficacy in treatment of moderate to severe degree organophosphorus poisoning with fresh frozen plasma, atropine and 2-pyridine aldoxime methyl chloride as compared to treatment with atropine and 2-pyridine aldoxime methyl chloride in Western Odisha

2020 ◽  
Vol 8 (10) ◽  
pp. 3513
Author(s):  
Purna C. Karua ◽  
Surya K. Parida
Keyword(s):  
Ventilatory Support ◽  
Methyl Chloride ◽  
Fresh Frozen Plasma ◽  
Serum Cholinesterase ◽  
Standard Regimen ◽  
Mean Values ◽  
Presenting Symptoms ◽  
Significant Difference ◽  
Fresh Frozen ◽  
Frozen Plasma

Background: Organophosphorus (OP) compounds are one of the most common agents used for suicidal poisoning. People in the middle socioeconomic status are mainly affected. The most important determinant of death in OP poisoning is the severity. The ideal treatment of OP poisoning, this study was undertaken to compare the efficacy of fresh frozen plasma (FFP) along with the standard regimen of atropine and oximes.Methods: 80 patients were taken in this study (40 cases and 40 controls) with history and biochemical pictures suggestive of acute OP poisoning. Normality assumption and equality of variance were satisfied for most of quantitative variables. As a comparison of the baseline data of the study groups did not reveal any significant difference (p>0.05), the result at a given point of time between two groups were also compared with the same methods of assess the comparative changes.Results: Total 80 patients >15 years of age were taken for the study. Out of the total 63.7% are female and 36.3% are males. OP compounds are commonly used as suicidal agent. Salivation is the most common presenting symptoms in both cases and controls. The mean value of serum cholinesterase on day -1 in cases and controls are nearly same but the subsequent mean values as the days progresses are higher in cases than that controls.Conclusions: FFP showed its positive effect in reducing the development of intermediate syndrome/ fatality/ ventilatory support. 

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