Low vitamin D levels affect outcomes of orthopedic spinal surgery: An observational study in clinical practice

2018 ◽  
Vol 26 (2) ◽  
pp. 305-317
Author(s):  
Jil B. Breidebach ◽  
Ernst M.W. Koch ◽  
Rahel Bornemann ◽  
Philip P. Roessler ◽  
Andreas Strauss ◽  
...  
2017 ◽  
Vol 4 (6) ◽  
pp. 1934
Author(s):  
T. Prashanth Reddy ◽  
Kishore Reddy ◽  
Madhu Sudhan Reddy ◽  
Manjunath G. A.

Background: Normal growth and development requires vitamin D, and its deficiency compromises long term health and increases the risk of chronic disease. Severe vitamin D deficiency include rickets, osteomalacia, osteoporosis, increased risk of fracture, tooth loss. Studies indicate that vitamin D insufficiency (less severe than deficiency) is associated with a wide range of illnesses and chronic conditions, including type 1 diabetes, hypertension, multiple sclerosis and many types of cancer. Currently world is facing an unrecognized and untreated pandemic of vitamin D deficiency. This study aims at showing the relation between Vitamin D status and obesity in adolescent children and to know the dietary factors, life style factors like physical activity contributing to overweight and obesity in adolescents.Methods: Study design: This is an observational study of 30 overweight and obese adolescents based on BMI were studied and their Vitamin D levels were assessed.Results: A total of 14(46.7%) overweight and 16(53.3%) obese adolescents Vitamin D levels were assessed. 20(66.7%) had vitamin D levels <20ng/ml that is in the deficiency range.4(13.3%) had in the insufficiency range (21-30ng/ml), 6(20%) had in the sufficient range. Results shows vitamin D levels were significantly less in obese and overweight adolescents.Conclusions: Study results confirm that Vitamin D deficiency or insufficiency is common to obese and overweight adolescents, this may help to explain the relationship between obesity and several chronic diseases that are associated with poor Vitamin D status.


2020 ◽  
Vol 09 (02) ◽  
pp. 093-100 ◽  
Author(s):  
Evelina Maines ◽  
Elisa Tadiotto ◽  
Grazia Morandi ◽  
Michela Fedrizzi ◽  
Rossella Gaudino ◽  
...  

AbstractThe use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. All patients were treated with a single infusion of neridronate at a dose of 1 to 2 mg/kg. The study provided two postinfusion reassessments: 24 hours (T24) and T48 after neridronate administration. Hypocalcemia was observed in 11% of patients at T24 and in 50% of patients at T48 from neridronate infusion. We observed a positive linear correlation between the baseline vitamin D values and postinfusion calcium values, both at baseline and at T24 and T48. Hypocalcemia was mild and asymptomatic in all cases. Postinfusion calcium levels were related to baseline vitamin D levels. Consequently, low vitamin D levels should be considered a significant risk factor for hypocalcemia and should be carefully investigated and treated before neridronate infusion.


2016 ◽  
Vol 22 ◽  
pp. 62
Author(s):  
Jothydev Kesavadev ◽  
Banshi Saboo ◽  
Arun Shankar ◽  
Sunitha Jothydev ◽  
Gopika Krishnan ◽  
...  

2021 ◽  
Author(s):  
Shyamajit Samaddar ◽  
Manvi Singh ◽  
Joseph Mathew ◽  
Naresh Sachdeva ◽  
Meenu Singh

Abstract Aim: To study the vitamin D levels in toddlers with recurrent wheezing.Methods: In this prospective observational study, 108 children aged 1-3 years with recurrent wheezing and 41 healthy age and sex matched controls were included. The clinical, demographic, socio-economic, food habits, and sun exposure of both the groups were assessed. The serum levels of vitamin D were measured and Asthma predictive index (API) of all the cases was calculated. Spearman or Pearson correlation coefficients were used to see relationship of different variables with Vitamin D.Results: Among 108 cases and 41 controls we enrolled, majority of them had vitamin D deficiency or insufficiency. The difference in vitamin D levels in the two groups was not statistically significant (p=0.0619). We found no significant difference in the vitamin D levels between, urban and rural population, vegetarians and non-vegetarians, adequately and inadequately sun light exposed children. There was also no correlation between the vitamin D levels and the number of wheezing episodes in the last 1 year. There was no significant correlation between the number of criteria of API positive and the vitamin D levels.Conclusion: Our study showed that the overall prevalence of vitamin D deficiency is very high among toddlers with recurrent wheezing. We conclude that vitamin D rich diet and sunlight exposure cannot prevent vitamin D deficiency in Indian toddlers. National programme for universal supplementation of vitamin D is required to control this epidemic of vitamin D deficiency.


2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Jonathan D. Adachi ◽  
Jacques P. Brown ◽  
George Ioannidis

Though vitamin D is important for bone health, little is known about the monitoring and management of vitamin D levels in patients with osteoporosis in clinical practice—a deficit this chart review initiative aimed to remedy. A total of 52 physicians completed profiles for 983 patients being treated for osteoporosis between November 2008 and April 2009. Information collected included demographics; fracture risk factors; availability and level of serum vitamin D measurements; and information on osteoporosis medications and calcium and vitamin D supplementation. Physicians also evaluated patients’ current regimens and detailed proposed changes, if applicable. Nearly 85% of patients were prescribed calcium and vitamin D supplements. Serum 25-hydroxy vitamin D levels were available for 73% of patients. Of these patients, approximately 50% had levels less than 80 nmol/L, which contrasts with the 37% thought to have “unsatisfactory” vitamin D levels based on physician perceptions. Physicians felt 26% of patients would benefit from additional vitamin D supplementation. However, no changes to the osteoporosis regimen were suggested for 48% of patients perceived to have “unsatisfactory” vitamin D levels. The results underscore the importance of considering vitamin D status when looking to optimize bone health.


PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0128223 ◽  
Author(s):  
Peter Bergman ◽  
Susanne Sperneder ◽  
Jonas Höijer ◽  
Jenny Bergqvist ◽  
Linda Björkhem-Bergman

2013 ◽  
Vol 30 (1) ◽  
pp. 74-77 ◽  
Author(s):  
Ingrid Bergström ◽  
Mats Palmér ◽  
Jan Persson ◽  
Agneta Blanck

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