scholarly journals An Automated Approach to Differentiate Drug Resistant Tuberculosis in Chest X-ray Images Using Projection Profiling and Mediastinal Features

2021 ◽  
Author(s):  
Sukanta Kumar Tulo ◽  
Palaniappan Ramu ◽  
Ramakrishnan Swaminathan
Keyword(s):  
Automated Analysis ◽  
Classification Performance ◽  
Support Vector ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Feature Lines ◽  
Contrast Enhanced ◽  
Chest X Ray ◽  
Clinically Significant

In this study, an attempt has been made to differentiate Drug Resistant Tuberculosis (DR-TB) in chest X-rays using projection profiling and mediastinal features. DR-TB is a condition which is non-responsive to at least one of anti-TB drugs. Mediastinum variations can be considered as significant image biomarkers for detection of DR-TB. Images are obtained from a public database and are contrast enhanced using coherence filtering. Projection profiling is used to obtain the feature lines from which the mediastinal and thoracic indices are computed. Classification of Drug Sensitive (DS-TB) and DR-TB is performed using three classifiers. Results show that the mediastinal features are found to be statistically significant. Support vector machine with quadratic kernel is able to provide better classification performance values of greater than 93%. Hence, the automated analysis of mediastinum could be clinically significant in differentiation of DR-TB.

scholarly journals Identifying drug-resistant tuberculosis from chest X-ray images using a simple convolutional neural network

2021 ◽  
Vol 2071 (1) ◽  
pp. 012001
Author(s):  
J Ureta ◽  
A Shrestha
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Binary Classification ◽  
Health Concern ◽  
Drug Resistant ◽  
X Rays ◽  
Drug Resistant Tuberculosis ◽  
X Ray ◽  
Resistant Tuberculosis ◽  
Chest X Ray

Abstract Tuberculosis(TB) is one of the top 10 causes of death worldwide, and drug-resistant TB is a major public health concern especially in resource-constrained countries. In such countries, molecular diagnosis of drug-resistant TB remains a challenge; and imaging tools such as X-rays, which are cheaply and widely available, can be a valuable supplemental resource for early detection and screening. This study uses a specialized convolutional neural network to perform binary classification of chest X-ray images to classify drug-resistant and drug-sensitive TB. The models were trained and validated using the TBPortals dataset which contains 2,973 labeled X-ray images from TB patients. The classifiers were able to identify the presence or absence of drug-resistant Tuberculosis with an AUROC between 0.66–0.67, which is an improvement over previous attempts using deep learning networks.

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