scholarly journals A STAT3 mutation in hyper-immunoglobulin E syndrome: A case report

2015 ◽  
Vol 02 (02) ◽  
pp. 091-096 ◽  
Author(s):  
Marielle Alders ◽  
Elke Dierckx ◽  
Paul Schil ◽  
Veronique Demeulemeester ◽  
Geert Mortier ◽  
...  
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Stat3 Mutation

scholarly journals Grover’s disease in a patient with atopic dermatitis - a case report

2021 ◽  
Vol 74 (1-2) ◽  
pp. 33-37
Author(s):  
Sanja Jakovljevic ◽  
Ljuba Vujanovic ◽  
Dejan Ogorelica ◽  
Aleksandra Fejsa-Levakov ◽  
Jasmina Sekulic
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Complete Regression ◽  
Laboratory Findings ◽  
Topical Corticosteroids

Introduction. Grover?s disease is characterized by pruriginous polymorphic rash with a variable course and duration. Although the etiology is still unknown, the disease is often associated with other dermatoses, malignant diseases, use of certain medications, as well as immunosuppression. Case Report. We report a case of a 70-year-old male patient who was referred for examination to the Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, due to a rash that lasted for nine months. The first lesions on the skin appeared around the nipples as exudative eczematous plaques. A few months later, identical lesions appeared on the lower legs. During treatment with systemic antihistamines and topical corticosteroids, there were episodes of transient improvements and re-exacerbations. In the meantime, erythematous brownish, round and oval papules appeared on the abdomen and the back, accompanied by intense itch. Laboratory findings revealed eosinophilia and elevated serum immunoglobulin E levels. A skin biopsy of the back lesion was performed and the histopathological examination confirmed the diagnosis of Grover?s disease. After the systemic treatment using corticosteroids and antihistamines, with gradual dose reduction and application of topical corticosteroids and emollients, complete regression of the skin lesions was achieved. Conclusion. Since the clinical manifestations of the disease may be nonspecific and discrete, dermatopathological analysis is of crucial importance in making the correct diagnosis. In patients with atopy, the treatment with systemic corticosteroids, antihistamines and topical agents may lead to regression of skin lesions with a significant improvement in the quality of life.

scholarly journals Kimura's Disease: A Case Report

2000 ◽  
Vol 79 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Sebastian J. Karavattathayyil ◽  
John R. Krause
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Salivary Glands ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Head And Neck Region

Kimura's disease is a rare, idiopathic condition that usually affects young men of Asian descent. The disease is characterized by swelling and lesions in the head and neck region, with involvement of the subcutaneous soft tissue, major salivary glands, and lymph nodes. Patients almost always have eosinophilia and elevated serum immunoglobulin E levels. The diagnosis is established by biopsy. Kimura's disease is usually self-limiting. Its etiology is unknown but is thought to be a manifestation of an aberrant allergic response. In this paper, we describe the case of a 30-year-old patient who was diagnosed with Kimura's disease at our institution.

scholarly journals No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity

2019 ◽  
Vol 10 ◽  
pp. 215265671989336
Author(s):  
Marija Rowane ◽  
Reimus Valencia ◽  
Benjamin Stewart-Bates ◽  
Jason Casselman ◽  
Robert Hostoffer
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Case Reports ◽  
The United States ◽  
Tick Saliva ◽  
Buffalo Meat ◽  
The Past ◽  
First Case ◽  
Delayed Anaphylaxis ◽  
History Of

Introduction Alpha (⍺)-gal syndrome (AGS) is an immunoglobulin E (IgE) antibody response against the glycoprotein carbohydrate galactose-⍺-1,3-galactose-β-1-(3)4-N-acetylglucosamine-R (Gal⍺-1,3Galβ1-(3)4GlcNAc-R or ⍺-gal) that is present in Ixodida (tick) saliva and noncatarrhine mammals as well as cetuximab, antivenom, and the zoster vaccine. The most frequently observed anaphylactic reactions in AGS are observed after beef, pork, lamb, and deer meat consumption. We present the first case of anaphylaxis to buffalo meat. Case Report A 55-year-old man presented with a history of recurrent urticaria that only developed approximately 7 hours after buffalo consumption. The patient denied history of Ixodidae bites but admitted to frequent hiking outdoors. Anti-⍺-1,3-gal IgE was positive (30.80 kU/L). The patient was advised to strictly avoid red meat. Discussion The prevalence of AGS has been increased in all continents in the past decade, and several Ixodidae species have been associated with this hypersensitivity. The list of IgE-mediated reactions to various types of meat has expanded to kangaroo, whale, seal, and crocodile, although these have not been associated with AGS. van Nunen only cautioned against consumption of exotic meats, such as buffalo, but no published case report describes AGS associated with anaphylaxis to this type of meat. Conclusion AGS is a mammalian meat allergy that has been increasingly prevalent worldwide, especially in Ixodidae endemic regions of Australia and the United States. Multiple AGS case reports published in the past decade demonstrate rapidly increasing understanding of underlying mechanisms provoking ongoing sensitization to help devise management strategies and dietary information. We offer the first case report of delayed anaphylaxis to buffalo meat.

scholarly journals Immunoglobulin E antibodies against a reactive dye--a case report.

1986 ◽  
Vol 12 (3) ◽  
pp. 221-222 ◽  
Author(s):  
Lars Hagmar ◽  
Hans Welinder ◽  
I Dahlquist
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Reactive Dye

scholarly journals Hyper-IgE Syndrome with STAT3 Mutation: A Case Report in Mainland China

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Lixin Xie ◽  
Xiaoxiang Hu ◽  
Yang Li ◽  
Weihua Zhang ◽  
Liang'an Chen
Keyword(s):  
Autosomal Dominant ◽  
Immunoglobulin E ◽  
Mainland China ◽  
High Serum ◽  
Deciduous Teeth ◽  
Autosomal Dominant Trait ◽  
Hyper Ige Syndrome ◽  
Stat3 Mutation ◽  
Transcription 3 ◽  
Human Signal

Hyper-immunoglobulin E syndromes (HIES) including compound primary immunodeficiency and nonimmunological abnormalities are characterized by extremely high serum IgE levels, eosinophilia, eczema, susceptibility to infections, distinctive facial appearance, retention of deciduous teeth, cyst-forming pneumonias, and skeletal abnormalities. Itis reported that some cases of familial HIES are relative to autosomal dominant or recessive inheritance, but most cases are sporadic, and result from mutations in the human signal transducer and activator of transcription 3 (STAT3) gene. In this paper, we firstly report a young man diagnosed of Hyper-IgE syndrome with STAT3 mutation in Mainland China, and investigate the autosomal dominant trait of his family members.

scholarly journals Hyper-immunoglobulin E (Job's syndrome): A rare case report

2017 ◽  
Vol 18 (1) ◽  
pp. 73
Author(s):  
Shubhankar Mishra ◽  
SunilK Agarwalla ◽  
Sadhana Panda ◽  
AshisK Patel
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Immunoglobulin E ◽  
Job’S Syndrome ◽  
Rare Case Report ◽  
Job's Syndrome

Oral observations of hyper immunoglobulin-e syndrome: A case report

2021 ◽  
Author(s):  
Ibtissam Dahabi ◽  
Fatima Zahra Benkarroum ◽  
Hakima Chhoul
Keyword(s):  
Case Report ◽  
Immunoglobulin E
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