Central diabetes insipidus: A rare complication of IVH in a very low birth weight preterm infant

2019 ◽  
Vol 12 (1) ◽  
pp. 103-107
Author(s):  
P. Thakore ◽  
A.E. Dunbar ◽  
E.B. Lindsay
2014 ◽  
Vol 133 (1) ◽  
pp. 60-63 ◽  
Author(s):  
Maria Lúcia Silveira Ferlin ◽  
Débora Simone Sales ◽  
Fábia Pereira Martins Celini ◽  
Carlos Eduardo Martinelli Junior

CONTEXT: Central diabetes insipidus (CDI) is a rare cause of hypernatremia during the neonatal period. The diagnosis is particularly difficult in very low birth weight (VLBW) newborns. CASE REPORT: We report on a preterm newborn who presented CDI soon after birth. On the third day of life, signs of dehydration were present despite normal fluid supply. The diuresis rate was 4.4 ml/kg/h. Although the fluid supply was then increased, the dehydration continued, with hypernatremia, normal glycemia, diuresis of 7.4 ml/kg/h and urine density of 1005 mOsmol/l. Thus, a diagnostic hypothesis of diabetes insipidus was raised. A test with a nasal vasopressin analogue (dDAVP) was performed and CDI was confirmed. Reduction of the fluid supply became possible through appropriate treatment. CONCLUSION: The diagnosis of CDI is rarely made during the neonatal period, especially in VLBW newborns, because of the difficulty in detecting elevated diuresis. Persistent hypernatremia, usually accompanied by hyperthermia despite abundant fluid supply, weight loss and low urine osmolality are important signs of alert.


2009 ◽  
Vol 28 (5) ◽  
pp. 452 ◽  
Author(s):  
Fabio Natale ◽  
Antonella Castronovo ◽  
Daniela Regoli ◽  
Mario De Curtis ◽  
Paolo Manzoni

1997 ◽  
Vol 7 (06) ◽  
pp. 364-366 ◽  
Author(s):  
G. Di Maggio ◽  
C. De Felice ◽  
M. Messina ◽  
G. Biagini ◽  
G. Tota ◽  
...  

PEDIATRICS ◽  
2002 ◽  
Vol 110 (5) ◽  
pp. e65-e65 ◽  
Author(s):  
L. Drohan ◽  
C. E. Colby ◽  
M. E. Brindle ◽  
S. Sanislo ◽  
R. L. Ariagno

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