Effect of probiotics on C-reactive protein levels in preterm infants: Secondary analysis of a randomized controlled trial

2018 ◽  
Vol 11 (2) ◽  
pp. 165-171 ◽  
Author(s):  
S. Agrawal ◽  
S. Rao ◽  
E.A. Nathan ◽  
S. Patole
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Randomized Controlled

scholarly journals Whole Grain Wheat Consumption Affects Postprandial Inflammatory Response in a Randomized Controlled Trial in Overweight and Obese Adults with Mild Hypercholesterolemia in the Graandioos Study

2019 ◽  
Vol 149 (12) ◽  
pp. 2133-2144 ◽  
Author(s):  
Femke P M Hoevenaars ◽  
Diederik Esser ◽  
Sophie Schutte ◽  
Marion G Priebe ◽  
Roel J Vonk ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Plasma Cholesterol ◽  
Controlled Trial ◽  
Elevated Plasma ◽  
Whole Grain ◽  
C Reactive Protein ◽  
Intervention Effects ◽  
Reactive Protein ◽  
Amyloid A ◽  
Randomized Controlled

ABSTRACT Background Whole grain wheat (WGW) consumption is associated with health benefits in observational studies. However, WGW randomized controlled trial (RCT) studies show mixed effects. Objectives The health impact of WGW consumption was investigated by quantification of the body's resilience, which was defined as the “ability to adapt to a standardized challenge.” Methods A double-blind RCT was performed with overweight and obese (BMI: 25–35 kg/m2) men (n = 19) and postmenopausal women (n = 31) aged 45–70 y, with mildly elevated plasma total cholesterol (>5 mmol/L), who were randomly assigned to either 12-wk WGW (98 g/d) or refined wheat (RW). Before and after the intervention a standardized mixed-meal challenge was performed. Plasma samples were taken after overnight fasting and postprandially (30, 60, 120, and 240 min). Thirty-one biomarkers were quantified focusing on metabolism, liver, cardiovascular health, and inflammation. Linear mixed-models evaluated fasting compared with postprandial intervention effects. Health space models were used to evaluate intervention effects as composite markers representing resilience of inflammation, liver, and metabolism. Results Postprandial biomarker changes related to liver showed decreased alanine aminotransferase by WGW (P = 0.03) and increased β-hydroxybutyrate (P = 0.001) response in RW. Postprandial changes related to inflammation showed increased C-reactive protein (P = 0.001), IL-6 (P = 0.02), IL-8 (P = 0.007), and decreased IL-1B (P = 0.0002) in RW and decreased C-reactive protein (P < 0.0001), serum amyloid A (P < 0.0001), IL-8 (P = 0.02), and IL-10 (P < 0.0001) in WGW. Health space visualization demonstrated diminished inflammatory (P < 0.01) and liver resilience (P < 0.01) by RW, whereas liver resilience was rejuvenated by WGW (P < 0.05). Conclusions Twelve-week 98 g/d WGW consumption can promote liver and inflammatory resilience in overweight and obese subjects with mildly elevated plasma cholesterol. The health space approach appeared appropriate to evaluate intervention effects as composite markers. This trial was registered at www.clinicaltrials.gov as NCT02385149.

scholarly journals No Reduction in C-Reactive Protein following a 12-Month Randomized Controlled Trial of Exercise in Men and Women

2008 ◽  
Vol 17 (7) ◽  
pp. 1714-1718 ◽  
Author(s):  
Kristin L. Campbell ◽  
Peter T. Campbell ◽  
Cornelia M. Ulrich ◽  
Mark Wener ◽  
Catherine M. Alfano ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
No Reduction ◽  
Controlled Trial ◽  
C Reactive Protein ◽  
Men And Women ◽  
Reactive Protein ◽  
Randomized Controlled
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