Awareness of risk factors and preventive measures for neural tube defects: Perception towards pregnancy termination in the Saudi population

2019 ◽  
Vol 12 (2) ◽  
pp. 195-201
Author(s):  
Mohammed A. Babgi ◽  
Hatim M. Al-Jifree ◽  
Omar A. AlShehri ◽  
Muhammad A. Khan ◽  
Ahmad N. Khogeer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Preventive Measures ◽  
Pregnancy Termination ◽  
Saudi Population

scholarly journals Spectrum of prenatally diagnosed neural tube defects at a tertiary referral hospital in North India: a retrospective cohort study

2020 ◽  
Vol 7 (10) ◽  
pp. 2010
Author(s):  
Nisha Malik ◽  
Savita Rani Singhal ◽  
Smiti Nanda ◽  
Daya Sirohiwal ◽  
Pushpa Dahiya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Incidence Rate ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Pregnancy Termination ◽  
Public Awareness

Background: Neural tube defects, although largely preventable, constitute an important cause of neonatal mortality and morbidity. The study aimed to identify incidence rate, demographic profile, risk factors, and pregnancy outcomes of women with prenatally diagnosed NTDs.Methods: This retrospective cohort study reviewed the case records of all antenatal women admitted in labour ward of Pt. B.D Sharma postgraduate institute of medical sciences, Rohtak, India with the prenatal diagnosis of NTDs on ultrasound from August 2018 to January 2020. The sociodemographic details, risk factors, obstetric history and pregnancy outcomes were noted. The mean, standard deviation and range values were calculated for normally distributed data. Categorical data were presented as frequency and percentage values.Results: From a total of 21,187 births, 90 had neural tube defects, making an incidence rate of 4.3 per 1000 births. Out of the 86 included cases of NTDs, 46.5% (n=40) had anencephaly, 45.3% (n=39) spina bifida, 5.8% (n=5) encephalocele and 2.3% (n=2) had mixed defects. Majority (69.7%, n=60) of the women were multigravida with a mean age of 24.9±4.2 years. Preconceptional folic acid intake was found in merely 2.3% (n=2) cases and during first trimester of pregnancy in 39.5% (n=40) cases. About 61.6% (n=53) cases who presented at ≤20 weeks gestation underwent pregnancy termination while 38.3% (n=33) had vaginal delivery, of which majority (90.7%) were still births.Conclusions: NTDs are one of the commonest preventable congenital anomalies. Ensuring periconceptional folate supplementation to women-either by food fortification, dietary modification and public awareness is urgently required.

Neural tube defects: Risk factors and preventive measures

2017 ◽  
Vol 57 (5) ◽  
pp. 150-156 ◽  
Author(s):  
Atsuo Kondo ◽  
Takuya Matsuo ◽  
Nobuhito Morota ◽  
Atsuya S. Kondo ◽  
Ikuyo Okai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Preventive Measures

scholarly journals Congenital anomalies and associated risk factors in a Saudi population: a cohort study from pregnancy to age 2 years

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e026351 ◽  
Author(s):  
Ahmed M Kurdi ◽  
Muhammad Ali Majeed-Saidan ◽  
Maha S Al Rakaf ◽  
Amal M AlHashem ◽  
Lorenzo D Botto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Risk Factor ◽  
Neural Tube ◽  
Congenital Anomalies ◽  
Tertiary Care ◽  
Chromosomal Anomalies ◽  
Saudi Population ◽  
Tertiary Care Centre ◽  
Renal Malformations

ObjectiveTo assess the three key issues for congenital anomalies (CAs) prevention and care, namely, CA prevalence, risk factor prevalence and survival, in a longitudinal cohort in Riyadh, Saudi Arabia.SettingTertiary care centre, Riyadh, Saudi Arabia.ParticipantsSaudi women enrolled during pregnancy over 3 years and their 28 646 eligible pregnancy outcomes (births, stillbirths and elective terminations of pregnancy for foetal anomalies). The nested case-control study evaluated the CA risk factor profile of the underlying cohort. All CA cases (1179) and unaffected controls (1262) were followed through age 2 years. Referred mothers because of foetal anomaly and mothers who delivered outside the study centre and their pregnancy outcome were excluded.Primary outcome measuresPrevalence and pattern of major CAs, frequency of CA-related risk factors and survival through age 2 years.ResultsThe birth prevalence of CAs was 412/10 000 births (95% CI 388.6 to 434.9), driven mainly by congenital heart disease (148 per 10 000) (95% CI 134 to 162), renal malformations (113, 95% CI 110 to 125), neural tube defects (19, 95% CI 25.3 to 38.3) and chromosomal anomalies (27, 95% CI 21 to 33). In this study, the burden of potentially modifiable risk factors included high rates of diabetes (7.3%, OR 1.98, 95% CI 1.04 to 2.12), maternal age >40 years (7.0%, OR 2.1, 95% CI 1.35 to 3.3), consanguinity (54.5%, OR 1.5, 95% CI 1.28 to 1.81). The mortality for live births with CAs at 2 years of age was 15.8%.ConclusionsThis study documented specific opportunities to improve primary prevention and care. Specifically, folic acid fortification (the neural tube defect prevalence was >3 times that theoretically achievable by optimal fortification), preconception diabetes screening and consanguinity-related counselling could have significant and broad health benefits in this cohort and arguably in the larger Saudi population.

Association of maternal risk factors with the recent rise of neural tube defects in Canada

2019 ◽  
Vol 33 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Shiliang Liu ◽  
Jane Evans ◽  
Amanda J. MacFarlane ◽  
Cande V. Ananth ◽  
Julian Little ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Maternal Risk Factors ◽  
Maternal Risk

scholarly journals Evaluation of proton-coupled folate transporter (SLC46A1 ) polymorphisms as risk factors for neural tube defects and oral clefts

2016 ◽  
Vol 170 (4) ◽  
pp. 1007-1016 ◽  
Author(s):  
Julia E. VanderMeer ◽  
Tonia C. Carter ◽  
Faith Pangilinan ◽  
Adam Mitchell ◽  
Emma Kurnat-Thoma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Oral Clefts

Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects

2003 ◽  
Vol 80 (4) ◽  
pp. 463-468 ◽  
Author(s):  
Anne Parle-McDermott ◽  
Edward J McManus ◽  
James L Mills ◽  
Valerie B O’Leary ◽  
Faith Pangilinan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects

scholarly journals Proportion of neural tube defects attributable to known risk factors

2012 ◽  
Vol 97 (1) ◽  
pp. 42-46 ◽  
Author(s):  
A. J. Agopian ◽  
Sarah C. Tinker ◽  
Philip J. Lupo ◽  
Mark A. Canfield ◽  
Laura E. Mitchell ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects
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