Effects of conjugated linoleic acid supplementation on serum leptin levels, oxidative stress factors and tumor marker in rectal cancer patients undergoing preopeatrive chemoradiotherapy

2021 ◽  
pp. 1-9
Author(s):  
Elnaz Faramarzi ◽  
Mohammad Mohammadzadeh ◽  
Sarvin Sanaie ◽  
Vibeke Andersen ◽  
Reza Mahdavi
Keyword(s):  
Rectal Cancer ◽  
Placebo Group ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Cancer Patients ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Stress Factors ◽  
Serum Leptin ◽  
Major Factors

BACKGROUND: Inflammation is considered as one of the major factors in chemoradiotherapy toxicity. It has been reported that conjugated linoleic acid (CLA) has anti-inflammatory properties. OBJECTIVE: The aim of this study was to assess the effect of CLA supplementation on serum levels of leptin, interleukin 8 (IL-8), malondialdehyde (MDA), total antioxidant status (TAS), and carcinoembryonic antigen (CEA) in rectal cancer patients treated with chemoradiotherapy. METHODS: In this study, 34 rectal cancer patients were allocated to either the CLA group, who received four 1000 mg capsules (each capsule containing 760 mg CLA; 4 capsules providing 3 g CLA) 3 times/day, or the placebo group, who received 4 placebo capsules 3 times/day, for 6 weeks. RESULTS: The mean serum leptin level insignificantly increased in both groups; however, this elevation was remarkable in the CLA group. CLA supplementation reduced IL-8 by –0.62 pg/mL while placebo supplementation decreased it by –0.44 pg/mL. CEA levels were decreased by CLA supplementation, while its reduction in the placebo group was negligible compared to the CLA group. The elevation of MDA levels after CLA supplementation was about half of the placebo group in the CLA group. CONCLUSION: Since this study was the first to assess the effect of CLA supplementation on a small number of cancer patients, it is suggested further studies are conducted on larger sample size with various doses of CLA to obtain more clear results.

A Pilot Study to Evaluate the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis

2019 ◽  
Vol 15 (3) ◽  
pp. 246-253 ◽  
Author(s):  
Ghazal Hashemi ◽  
Mahtabalsadat Mirjalili ◽  
Zahra Basiri ◽  
Ahmad Tahamoli-Roudsari ◽  
Nejat Kheiripour ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Placebo Group ◽  
Inflammatory Cytokines ◽  
Serum Levels ◽  
Stress Factors ◽  
Oxidative Stress Biomarkers ◽  
Significant Difference ◽  
Acetyl Cysteine ◽  
And Oxidative Stress

<P>Background: Rheumatoid Arthritis (RA) is a common inflammatory disease of the joints. Due to the importance of inflammation and oxidative stress in the pathogenesis of RA, drugs that have anti-oxidant and anti-inflammatory properties, such as N-acetyl Cysteine (NAC), can be used as adjunctive therapy in patients with RA. </P><P> Aims: The aim of this study was to evaluate the effects of oral NAC on inflammatory cytokines and oxidative stress in patients with RA. </P><P> Methods: Adjunct to standard treatment, the NAC group (23 patients) received 600 mg of NAC twice daily and the placebo group (19 patients) received identical placebo twice daily for 12 weeks. Serum levels of Total Oxidant Status (TOS), Total Antioxidant Capacity (TAC), nitric oxide (NO), Total Thiol Groups (TTG), Malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-&#945;), interleukin- 6 (IL-6), C-reactive Protein (CRP), and Erythrocyte Sedimentation Rate (ESR) were measured at baseline and at the end of the study. </P><P> Results: Results showed that in the NAC group, the serum levels of MDA, NO, IL-6, TNF-&#945;, ESR and CRP were significantly lower than the baseline. Also, the serum level of TAC and TTG, as antioxidant parameters, increased significantly. However, only NO, MDA and TTG showed a significant difference in the NAC group as compared to the placebo group at the end of study. </P><P> Conclusion: According to the results of this study, oral NAC can significantly reduce the several oxidative stress factors and inflammatory cytokines. These results need to be confirmed in larger studies while considering clinical outcomes of RA patients.</P>

The effects of conjugated linoleic acid supplementation on the serum levels of Interleukin-6 and Sirtuin-1 in COPD patients

2019 ◽  
Author(s):  
Hassan Ghobadi-Marallu ◽  
Somaieh Matin ◽  
Ali Nemati ◽  
Mehran Mesgari-Abbasi ◽  
Saeid Ghorbani ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Interleukin 6 ◽  
Serum Levels ◽  
Sirtuin 1 ◽  
Acid Supplementation ◽  
Copd Patients

Conjugated Linoleic Acid Content in Breast Adipose Tissue of Breast Cancer Patients and the Risk of Metastasis

2003 ◽  
Vol 45 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Véronique Chajès ◽  
Flore Lavillonnière ◽  
Virginie Maillard ◽  
Bruno Giraudeau ◽  
Marie-Lise Jourdan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Cancer Patients ◽  
Acid Content ◽  
Linoleic Acid Content ◽  
Breast Cancer Patients ◽  
Breast Adipose Tissue ◽  
Breast Adipose

scholarly journals Bacterial conjugated linoleic acid bio-fortification of synbiotic yogurts using Propionibacterium freudenreichii as adjunct culture

2021 ◽  
Vol 33 (SP1) ◽  
pp. 1-11
Author(s):  
Omid Zahed ◽  
Kianoush Khosravi-Darani ◽  
S. Amir Mortazavian Farsani ◽  
Abdoreza Mohammadi
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Milk Fat ◽  
Screening Method ◽  
Skim Milk ◽  
Propionibacterium Freudenreichii ◽  
Fat Percentage ◽  
Oil Concentration ◽  
Burman Design ◽  
Major Factors

In this study, Propionibacterium freudenreichii was used for in situ production of conjugated linoleic acid (CLA) in yogurt. Firstly, effects of process variables, including strain type, percentage of milk fat, percentage of inoculum, quantity of sunflower oil, concentration of inulin, temperature of fermentation and time of storage at 4°C, on production of CLA by Propionibacterium freudenreichii were investigated using screening method of the Plackett–Burman design. Then optimisation of CLA production process was conducted using three major factors of milk fat percentage, inulin concentration and storage time at 4°C using central composite design. Analysis of variance established that the models were highly significant (P ? 0.05). The model demonstrated that the production of CLA was affected by these three factors. Optimised CLA production by Propionibacterium freudenreichii ssp. shermanii in yogurts was achieved after 17 days of storage at 4°C in skim-milk containing 1.75% (w/w) fat and 2.25% (w/v) inulin as prebiotic. Reconfirmation test established that at the highlighted optimum conditions, the highest concentration of produced CLA was 6.4 mg g–1 lipid in yogurt, which is a 256% increase in total CLA production, compared with control samples. Results demonstrated that Propionibacterium freudenreichii ssp. shermanii not only leads to production of synbiotic yogurts containing inulin but also increases CLA production in yogurts.

Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats

Nutrition ◽  
2001 ◽  
Vol 17 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Shaikh Mizanoor Rahman ◽  
Yu-Ming Wang ◽  
Hiroaki Yotsumoto ◽  
Jae-Young Cha ◽  
Seo-Young Han ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Body Fat ◽  
Serum Leptin ◽  
Fat Accumulation ◽  
Oletf Rats
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