The relationship between vitamin D deficiency and metabolic syndrome in veterans of Iran-Iraq war

2020 ◽  
Vol 13 (2) ◽  
pp. 127-134
Author(s):  
Parisa Hashemizadeh ◽  
Reza Shekarriz-Foumani ◽  
Mahtab Niroomand
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Iraq War ◽  
The Relationship

scholarly journals The relationship between vitamin D deficiency and metabolic syndrome in obese individuals

2018 ◽  
Vol 7 (4) ◽  
pp. 275-279
Author(s):  
Mahmood Mirhoseini ◽  
Hamid Daemi ◽  
Mahshid Masoom Babaiee ◽  
Majid Asadi-Samani ◽  
Leilaassadat Mirhoseini ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
The Relationship

scholarly journals Relationship of arterial hypertension, metabolic syndrome with vitamin D deficiency in women

2020 ◽  
Vol 43 (4) ◽  
pp. 549-559
Author(s):  
Lyudmila V. Vasilieva ◽  
◽  
Yuliya V. Tatarintseva ◽  
Elena V. Gosteva ◽  
Sergej Y. Popov ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Arterial Hypertension ◽  
Blood Serum ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Blood Pressure Monitoring ◽  
Low Hdl ◽  
Relationship Of ◽  
The Relationship

Objective: To assess the relationship between vitamin D deficiency (VD) and risk factors for metabolic syndrome (MS) in postmenopausal women with arterial hypertension (AH). Materials and methods of research. The study included 46 women aged 45–65 years with amenorrhea > 12 months, having grade 1 hypertension and metabolic syndrome. Anthropometric, laboratory and instrumental data were studied. Biochemical parameters included total cholesterol (OH), HDL, triglycerides, glucose, insulin, and 25-hydroxyvitamin-D [25 (OH)D]. Daily blood pressure monitoring was performed according to the standard protocol. Levels of 25(OH)D in blood serum was classified as-adequate (≥ 30 ng/ml) and insufficient (20–29 ng/ml). Results: Level 25 (OH)D in blood serum was sufficient in 21 women (45.6 %), insufficient – in 25 (54.4 %). Women with insufficient levels of 25 (OH)D had higher levels of cholesterol, triglycerides, insulin, and HOMA-IR. Metabolic syndrome was detected in 64 % (16/25) of women with hypovitaminosis D and in 43 % (9/21) of women with sufficient VD (p < 0.01). The correlation analysis established the relationship of the low level of 25 (OH)D (< 30 ng / ml) with MS (r = 0.68), high triglycerides (r = 0.74) and low HDL (r = 0.71). The average concentration of 25 (OH) D decreased with an increase in the number of MS components (p = 0.016). Conclusions: VD deficiency in postmenopausal women was associated with a higher prevalence of MS. Women with HDL deficiency had a higher risk of MS, hypertriglyceridemia, and low HDL levels compared to those with adequate levels.

Vitamin D deficiency and risk of metabolic syndrome

2018 ◽  
Author(s):  
Alena Andreeva ◽  
Olga Belyaeva ◽  
Anna Bystrova ◽  
Elena Bajenova ◽  
Tatiana Karonova
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency

Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3

2020 ◽  
Vol 20 (8) ◽  
pp. 1282-1294
Author(s):  
Meroua Bouchemal ◽  
Djennat Hakem ◽  
Malha Azzouz ◽  
Chafia Touil-Boukoffa ◽  
Dalila Mezioug
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Active Metabolite ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
No Production ◽  
Immunomodulatory Effects ◽  
Immune Balance ◽  
Vitamin D Levels

Background: Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It is associated with the presence of various inflammatory molecules. Vitamin D plays an important role in the regulation of metabolism homeostasis. Objective: The main goal of this work is to investigate vitamin D levels among Algerian MetS patients and its possible outcomes on key molecules of the immune response, as well, the immunomodulatory effects of its active metabolite. Methods: We evaluated vitamin D status by the electrochemiluminescence method, Nitric Oxide (NO) levels by the Griess method and Matrix Metalloproteinases (MMPs) activities such as MMP-2 and MMP-9 by zymography in plasma of patients and healthy controls (HC). The immunomodulatory effects of the active metabolite of vitamin D (α-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF- β and s-CTLA-4 were assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. MMPs activities were also determined ex-vivo, while iNOS expression was assessed by immunofluorescence staining. Results: Severe vitamin D deficiency was registered in Algerian MetS patients. The deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity. Interestingly, α-25 (OH)2D3 declined the NO/iNOS system and IL-6 production, as well as MMPs activities. However, the ex-vivo production of IL-10, TGF-β increased in response to the treatment. We observed in the same way, the implication of s-CTLA-4 in MetS, which was markedly up-regulated with α-25 (OH)2D3. Conclusion: Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance.

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

scholarly journals The Relationship between Vitamin D Deficiency and Pulmonary Artery Atherosclerosis in Chronic Thromboembolic Patients

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Tarik Kivrak ◽  
Hasan Ata Bolayir ◽  
Batur Gonenc Kanar ◽  
Dursun Akaslan ◽  
Hakan Gunes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Artery ◽  
Vitamin D Deficiency ◽  
The Relationship

scholarly journals Prevalence of Vitamin D Deficiency, Metabolic Syndrome and Association Between the Two in a South Asian Population

2018 ◽  
Vol 08 (02) ◽  
Author(s):  
Ramesh Reddy Allam ◽  
Rashmi Pant ◽  
Chengappa K Uthappa ◽  
Manjunath Dinaker ◽  
Ganesh Oruganti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
South Asian ◽  
Asian Population ◽  
South Asian Population
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