scholarly journals People with Parkinson’s Disease: What Symptoms Do They Most Want to Improve and How Does This Change with Disease Duration?

2021 ◽  
pp. 1-10
Author(s):  
Rebecca J. Port ◽  
Martin Rumsby ◽  
Graham Brown ◽  
Ian F. Harrison ◽  
Anneesa Amjad ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Psychological Health ◽  
Online Survey ◽  
Disease Duration ◽  
Future Research ◽  
Free Text ◽  
Motor Symptoms ◽  
Walking Balance ◽  
Non Motor Symptoms

Background: Parkinson’s disease (PD) is a neurodegenerative condition with a diverse and complex pattern of motor and non-motor symptoms which change over time with disease duration. Objective: The aims of the present study were to discover what symptoms matter most to people with the condition and to examine how these priorities change with disease duration. Methods: A simple free-text online survey (using SmartSurvey) was developed by Parkinson’s UK, which asked participants to identify up to three aspects of the condition they would most like to see improvement in. Results: 790 people participated reporting 2,295 issues related to PD which were grouped into 24 broad symptom domains. Of these, 1,358 (59.1%) were categorised as motor symptoms, 859 (37.4%) as non-motor issues and 78 (3.4%) as medication problems. This study reveals how certain features of PD become more or less important to patients as the condition progresses. Non-motor symptoms were highly cited from the very earliest stages of PD. Problems with walking, balance and falls, speech problems, freezing and dyskinesia become increasingly important as the condition progresses whereas tremor, stiffness and psychological health become decreasingly important as the condition progresses. Conclusions: The data suggest that the priorities of people affected by PD for improving life are personal and change with duration of the condition. These findings have implications for developing person-centred management and care, as well as for directing future research to improve quality of life.

scholarly journals Memory deficits in Parkinson’s disease are associated with reduced beta power modulation

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Hayley J MacDonald ◽  
John-Stuart Brittain ◽  
Bernhard Spitzer ◽  
Simon Hanslmayr ◽  
Ned Jenkinson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Duration ◽  
Memory Formation ◽  
Motor Deficits ◽  
Beta Activity ◽  
Motor Symptoms ◽  
Memory Encoding ◽  
Beta Power ◽  
Non Motor Symptoms

Abstract There is an increasing recognition of the significant non-motor symptoms that burden people with Parkinson’s disease. As such, there is a pressing need to better understand and investigate the mechanisms underpinning these non-motor deficits. The electrical activity within the brains of people with Parkinson’s disease is known to exhibit excessive power within the beta range (12–30 Hz), compared with healthy controls. The weight of evidence suggests that this abnormally high level of beta power is the cause of bradykinesia and rigidity in Parkinson’s disease. However, less is known about how the abnormal beta rhythms seen in Parkinson’s disease impact on non-motor symptoms. In healthy adults, beta power decreases are necessary for successful episodic memory formation, with greater power decreases during the encoding phase predicting which words will subsequently be remembered. Given the raised levels of beta activity in people with Parkinson’s disease, we hypothesized that the necessary decrease in power during memory encoding would be diminished and that this would interfere with episodic memory formation. Accordingly, we conducted a cross-sectional, laboratory-based experimental study to investigate whether there was a direct relationship between decreased beta modulation and memory formation in Parkinson’s disease. Electroencephalography recordings were made during an established memory-encoding paradigm to examine brain activity in a cohort of adults with Parkinson’s disease (N = 28, 20 males) and age-matched controls (N = 31, 18 males). The participants with Parkinson’s disease were aged 65 ± 6 years, with an average disease duration of 6 ± 4 years, and tested on their normal medications to avoid the confound of exacerbated motor symptoms. Parkinson’s disease participants showed impaired memory strength (P = 0.023) and reduced beta power decreases (P = 0.014) relative to controls. Longer disease duration was correlated with a larger reduction in beta modulation during encoding, and a concomitant reduction in memory performance. The inability to sufficiently decrease beta activity during semantic processing makes it a likely candidate to be the central neural mechanism underlying this type of memory deficit in Parkinson’s disease. These novel results extend the notion that pathological beta activity is causally implicated in the motor and (lesser appreciated) non-motor deficits inherent to Parkinson’s disease. These findings provide important empirical evidence that should be considered in the development of intelligent next-generation therapies.

scholarly journals Quality of Life in Newly Diagnosed Patients With Parkin-Related Parkinson's Disease

2020 ◽  
Vol 11 ◽  
Author(s):  
Xin-Yue Zhou ◽  
Feng-Tao Liu ◽  
Chen Chen ◽  
Su-Shan Luo ◽  
Jue Zhao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Disease Duration ◽  
Motor Symptoms ◽  
Newly Diagnosed ◽  
Non Motor Symptoms

Introduction: Mutations in the Parkin gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in Parkin-related PD. Here, we investigated the patterns of QoL in newly diagnosed Parkin-related PD patients.Methods: Newly diagnosed PD patients (diagnosis made within 12 months) who had an age of onset (AOO) below 40 and underwent a PD-related genetic testing, were recruited (n = 148). Among them, 24 patients carried bi-allelic variants in Parkin (PD-Parkin) and 24 patients did not have any known causative PD mutations, or risk variants (GU-EOPD). The clinical materials, relevant factors and determinants of QoL were analyzed.Results: PD-Parkin patients had a younger AOO (p = 0.003) and longer disease duration (p = 0.005). After adjustment for AOO and disease duration, more dystonia (p = 0.034), and worse scores of non-motor symptoms including Beck depression inventory (BDI, p = 0.035), Epworth sleepiness scale (ESS, p = 0.044), and subdomains of depression/anxiety (p = 0.015) and sleep disorders (p = 0.005) in Non-motor symptoms questionnaire, were found in PD-Parkin comparing with GU-EOPD. PD-Parkin patients had poorer QoL (adjusted p = 0.045), especially in the mobility (adjusted p = 0.025), emotional well-being (adjusted p = 0.015) and bodily discomfort dimensions (adjusted p = 0.016). BDI scores (p = 0.005) and ESS scores (p = 0.047) were significant determinants of QoL in PD-Parkin.Conclusion: Newly diagnosed PD-Parkin patients showed worse QoL. More depression and excessive daytime sleepiness predicted worse QoL. For clinicians, management of depression and excessive daytime sleepiness is suggested to better improve QoL in patients with Parkin mutations.

scholarly journals The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yi-Chieh Chen ◽  
Rou-Shayn Chen ◽  
Yi-Hsin Weng ◽  
Ying-Zu Huang ◽  
Chiung Chu Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Disease Duration ◽  
Rating Scale ◽  
Medical Center ◽  
Motor Symptoms ◽  
Disease Rating ◽  
Non Motor Symptoms

AbstractNonmotor symptoms (NMSs) cause major burden in patients with Parkinson’s disease (PD). Previous NMSs progression studies mostly focused on the prevalence. We conducted a longitudinal study to identify the progression pattern by the severity. PD patients recruited from the outpatient clinics of a tertiary medical center were evaluated by the Unified Parkinson's Disease Rating Scale and Non-Motor Symptoms Scale (NMSS). A retrospective study with three-step analysis was performed. Step 1, the NMSs severity was compared among patients stratified by disease duration every 2 years up to 10 years. Step 2, patients with repeated tests in 2 years were categorized into 4 groups by the diseased duration of every 5 years. Step 3, the NMSS score changes in 6 years follow-up were determined, and the dosage of anti-PD drugs was compared to the NMSs severity changes. 676 patients completed the step 1 analysis, which showed a trend of NMSs worsening but not significant until the disease duration longer than 4–6 years. Furthermore, the severity did not change between repeated evaluations in 2 years in all patients. The progression became apparent after 6 years. Individual symptoms had different progression patterns and the increment of medications was independent to NMSs evolution. We demonstrated the NMSs severity progression in Taiwanese PD patients and the independence of the medications and NMSs progression.

scholarly journals Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Anouk van der Heide ◽  
Anne E. M. Speckens ◽  
Marjan J. Meinders ◽  
Liana S. Rosenthal ◽  
Bastiaan R. Bloem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Perceived Stress ◽  
Online Survey ◽  
Neuropsychiatric Symptoms ◽  
Motor Symptoms ◽  
Dispositional Mindfulness ◽  
Mindfulness Skills ◽  
Self Compassion ◽  
Non Motor Symptoms

AbstractMany Parkinson’s disease (PD) patients notice that motor symptoms worsen during stress, and experience stress-related neuropsychiatric symptoms such as anxiety and depression. Here we investigated which personal and disease characteristics are associated with perceived stress in PD, which PD symptoms are sensitive to stress, and we assessed self-reported benefits of stress-reducing strategies such as mindfulness. We sent an online survey to the Fox Insight cohort (n = 28,385 PD patients, n = 11,413 healthy controls). The survey included specific questions about the influence of stress on PD symptoms, use of stress-reducing strategies, and several validated scales measuring perceived stress, anxiety, dispositional mindfulness, rumination, and self-compassion. We received completed surveys from 5000 PD patients and 1292 controls. Patients perceived more stress than controls. Among patients, stress was correlated with increased rumination (R = 0.65), lower quality of life (R = −0.56), lower self-compassion (R = −0.65), and lower dispositional mindfulness (R = −0.48). Furthermore, patients indicated that stress significantly worsened both motor symptoms – especially tremor – and non-motor symptoms. Physical exercise was most frequently used to reduce stress (83.1%). Mindfulness was practiced by 38.7% of PD respondents, who noticed improvement in both motor and non-motor symptoms. Among non-users, 43.4% were interested in gaining mindfulness skills. We conclude that PD patients experience greater levels of stress than controls, and that stress worsens both motor and non-motor symptoms. Mindfulness may improve PD symptom severity, with the strongest effects on anxiety and depressed mood. These findings justify further controlled studies to establish the merits of mindfulness and other stress-alleviating interventions.

scholarly journals Self-Reported Symptoms of Parkinson’s Disease by Sex and Disease Duration

2016 ◽  
Vol 39 (11) ◽  
pp. 1412-1428 ◽  
Author(s):  
Ju Young Shin ◽  
Ryan T. Pohlig ◽  
Barbara Habermann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Duration ◽  
Community Dwelling ◽  
Motor Symptoms ◽  
Cross Sectional ◽  
Wide Range ◽  
Future Care ◽  
Descriptive Survey ◽  
Non Motor Symptoms

Parkinson’s disease (PD) is a neurodegenerative disease with a wide range of symptom presentations. The purpose of this research was to compare self-reported motor and non-motor symptoms of PD by sex and disease duration. This study was a cross-sectional descriptive survey in community-dwelling people with PD. A total of 141 participants (64.6% response rate; 59.6% men; Mage = 69.7 years) were included. Males reported more rigidity, speech problems, sexual dysfunction, memory problems, and socializing problems than females. The number of motor symptoms in three groups divided by increments of 5 years was significantly increased. Postural instability, freezing, off periods, dyskinesia, speech problems, and hallucinations/psychosis were significantly increased as the disease duration increased. Thorough assessment of motor and non-motor symptoms could decrease the risk of inadequate symptom management. Provision of information regarding PD symptoms at each stage may help people with PD and their caregivers in planning their future care and life.

Disease duration-related differences in non-motor symptoms: A study of 616 Chinese Parkinson's disease patients

2013 ◽  
Vol 330 (1-2) ◽  
pp. 32-37 ◽  
Author(s):  
Xiaoyan Guo ◽  
Wei Song ◽  
Ke Chen ◽  
XuePing Chen ◽  
Zhenzhen Zheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Duration ◽  
Motor Symptoms ◽  
Non Motor Symptoms

scholarly journals Translation, Adaptation and Validation of the European Portuguese Version of the NMS-Quest for Parkinson’s Disease

2020 ◽  
Vol 33 (13) ◽  
Author(s):  
Tiago Pedro ◽  
Fradique Moreira ◽  
Alexandra Silva
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Internal Consistency ◽  
Movement Disorders ◽  
Disease Duration ◽  
Motor Symptoms ◽  
Portuguese Version ◽  
European Portuguese ◽  
Floor Effects ◽  
Non Motor Symptoms

Introduction: Non-motor symptoms are underrecognized features of Parkinson’s disease that impair quality of life and increase mortality. In this study, we aim to translate, adapt and validate the European Portuguese version of the “Non-Motor Symptoms Questionnaire”, which has proven to be a valid and reliable measurement tool of non-motor symptoms in other languages.Material and Methods: Acceptability was evaluated regarding the range of values, ceiling and floor effects. Reliability was measured in terms of internal consistency (Cronbach’s alpha) and reproducibility (intra-class correlation coefficient). For criterion validity analysis, Movement Disorders Society – Unified Parkinson’s Disease Part I domains’ scores were compared to those of the “Non-Motor Symptoms Questionnaire”. For convergent validity, correlations between the “Non-Motor Symptoms Questionnaire” and the Movement Disorders Society – Unified Parkinson’s Disease Part III, Mini-Mental State Examination score, disease duration, and severity were obtained.Results: Seventy nine Parkinson’s disease patients were recruited, with a mean age of 67.2 ± 10.7 years and a disease duration of 10.8 ± 8.8 years. The European Portuguese version of the “Non-Motor Symptoms Questionnaire” total score was free of significant ceiling and floor effects. With the exception of the cardiovascular domain, adequate overall internal consistency was achieved. The questionnaire domains and the corresponding Movement Disorders Society – Unified Parkinson’s Disease Part I dimensions were significantly correlated, although the total questionnaire score was modestly correlated with disease duration and severity, motor and non-motor symptoms severity and cognitive dysfunction.Discussion: This is the first study to translate, adapt and validate a widely used screening instrument of non-motor symptoms of European Portuguese speaking Parkinson’s disease patients.Conclusion: The European Portuguese version of “Non-Motor Symptoms Questionnaire” is a valid and reliable tool for screening nonmotor symptoms in patients with Parkinson’s disease.

scholarly journals B-25 Osteopathic Manipulative Treatment Improves Non-Motor Symptoms in Parkinson’s Disease: A Preliminary Study

2019 ◽  
Vol 34 (6) ◽  
pp. 971-971
Author(s):  
N Whiteley ◽  
H King ◽  
A Cabrera Tuazon ◽  
C Pluim ◽  
M Nakhla ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Quality ◽  
Perceived Stress ◽  
Rating Scale ◽  
Future Research ◽  
Osteopathic Manipulative Treatment ◽  
Motor Symptoms ◽  
Preliminary Study ◽  
Non Motor Symptoms

Abstract Parkinson’s disease (PD) is a neurodegenerative disease characterized by debilitating motor and non-motor symptoms. Osteopathic Manipulative Treatment (OMT) has been shown to alleviate stress, mood, and sleep in musculoskeletal conditions and older adults, as well as improve gait and balance in PD and elderly patients, respectively. Research on the efficacy of OMT in reducing PD symptoms is lacking. Therefore, the aim of this preliminary study was to evaluate changes in mood, cognitive, and motor symptoms in a sample of non-demented PD patients following 6-weeks of OMT. Sixteen non-demented individuals with PD received 6 weekly 30-minute OMT by an osteopathic physician. Participants were administered measures of cognition (Parkinson’s Disease-Cognitive Rating Scale; PD-CRS), anxiety (Geriatric Anxiety Inventory; GAI), sleep quality (Pittsburgh Sleep Quality Index; PSQI), stress (Perceived Stress Scale; PSS), and motor function (Unified Parkinson’s Disease Rating Scale-Part 3) before and after treatment. Paired-samples t-tests were used to examine changes in symptoms pre and post-OMT. Results revealed significant improvement in cognition (PD-CRS; p = .015) and perceived stress (PSS; p = .02) from pre- to post-intervention. There was a trend towards improvement in anxiety (GAI; p = .064) and sleep quality (PSQI; p = .08). There was no change in motor symptoms from pre- to post-OMT (p = .56). Findings suggest that OMT may improve non-motor symptoms – particularly cognition and stress - in PD. Future research is needed to determine if these effects can be replicated within a randomized-control-trial and maintained over time. With further research, OMT may prove to be a beneficial non-invasive treatment for non-motor symptoms in PD.

scholarly journals Falls in persons with Parkinson's disease: Do non-motor symptoms matter as much as motor symptoms?

2019 ◽  
Vol 77 (11) ◽  
pp. 761-767 ◽  
Author(s):  
Alonso Alvarado-Bolaños ◽  
Amin Cervantes-Arriaga ◽  
Kenia Arredondo-Blanco ◽  
Karla Salinas-Barboza ◽  
Sara Isais-Millán ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Movement Disorders ◽  
Disease Duration ◽  
Rating Scale ◽  
Motor Symptoms ◽  
Risk Factors For Falls ◽  
Non Motor Symptoms

ABSTRACT Falls are common among persons with Parkinson's disease (PD). On the other hand, predicting falls is complex as there are both generic and PD-specific contributors. In particular, the role of non-motor symptoms has been less studied. Objective: The objective of this study was to identify the role of non-motor predictors of falling in persons with PD (PwP). Methods: A cross-sectional study was carried out in PwP recruited from a movement disorders clinic. Clinical and demographical data were collected. All PwP were assessed using the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Non-Motor Symptoms Scale (NMSS). Variables were assessed at the bivariate level. Significant variables were put into a logistic regression model. Results: A total of 179 PwP were included. Overall, 16.8% of PwP had fallen in the past 12 months, with 53.3% of them being recurrent fallers. The mean number of monthly falls was 2.5 ± 3.3. Factors associated with falling in the bivariate analysis included the disease duration, Hoehn and Yahr stage, MDS-UPDRS part I and II, postural instability/gait disturbance (PIGD) subtype, NMSS urinary domain, NMSS miscellaneous domain, and non-motor severity burden (all p-values < 0.05). After multivariate analysis, only the disease duration (p = 0.03) and PIGD (p = 0.03) remained as independent risk factors. Conclusion: Disease duration and the PIGD subtype were identified as relevant risk factors for falls in PwP Non-motor symptoms appear to have a less important role as risk factors for falls.

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